Piper betle

• Index
• Plant Species
• Natural Activity
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Piper betle
Genus	Piper
Family	Piperaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Piper betle
Linked NCBI taxonomy ID	13217
Linked level	species

Family

Family in NCBI taxonomy	Piperaceae
ID	16739

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Magnoliophyta
ID	3398

Natural Activity

List (41)

Species	Activity
Piper betle L.	Amebicide
Piper betle L.	Analgesic
Piper betle L.	Antibacterial
Piper betle L.	Antilactagogue
Piper betle L.	Antioxidant
Piper betle L.	Antiperstaltic
Piper betle L.	Antiseptic
Piper betle L.	Antispasmodic
Piper betle L.	Aperitif
Piper betle L.	Aphrodisiac
Piper betle L.	Astringent
Piper betle L.	Cardiotonic
Piper betle L.	Carminative
Piper betle L.	Cerebrotonic
Piper betle L.	CNS-Depressant
Piper betle L.	CNS-Stimulant
Piper betle L.	Collyrium
Piper betle L.	Contraceptive
Piper betle L.	Deobstruent
Piper betle L.	Digestive
Piper betle L.	Diuretic
Piper betle L.	Euphoric
Piper betle L.	Expectorant
Piper betle L.	Fungicide
Piper betle L.	Hemostat
Piper betle L.	Hepatotonic
Piper betle L.	Immunomodulator
Piper betle L.	Intoxicant
Piper betle L.	Laxative
Piper betle L.	Litholytic
Piper betle L.	Masticatory
Piper betle L.	Narcotic
Piper betle L.	Parasiticide
Piper betle L.	Sedative
Piper betle L.	Sialagogue
Piper betle L.	Sterilant
Piper betle L.	Stimulant
Piper betle L.	Stomachic
Piper betle L.	Tonic
Piper betle L.	Vermifuge
Piper betle L.	Vulnerary

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00003672	Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol	CHEMBL221542 CHEMBL1398443 CHEMBL1875388		17 / 19 / 12		No. 53	No. 11
C00035087	Dotriacontanoic acid	CHEMBL1917282	C049204	2 / 0 / 0		No. 115
C00001270	Triacontane		C070808			No. 115
C00025787	Cepharadione A	CHEMBL235921				No. 125
C00001238	Stearic acid	CHEMBL46403	C031183	15 / 17 / 19	6 / 1	No. 184	No. 68
C00042857	Piperlonguminine	CHEMBL249652 CHEMBL253973 CHEMBL254178		8 / 5 / 3		No. 638
C00033681	beta-Sitosterol palmitate					No. 1152
C00000619	Eugenol	CHEMBL42710	D005054	103 / 45 / 36	152 / 28	No. 1852	No. 6
C00002740	Estragol / Esdragol / Estragole	CHEMBL470671	C007633	10 / 16 / 43	3 / 5	No. 3933	No. 6
C00002065	Piperine / Bioperine / 1-Piperoylpiperidine	CHEMBL43185 CHEMBL1395862		32 / 47 / 64		No. 4209	No. 1

Human Protein / Gene in interactions

155 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P16473	Thyrotropin receptor	Glycohormone receptor	C00001238 C00002065 C00002740 C00003672	3 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000619 C00002065 C00002740 C00003672	0 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00000619 C00002065 C00002740	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000619 C00002065 C00003672	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000619 C00002065 C00003672	1 / 1
P04150	Glucocorticoid receptor	NR3C1	C00000619 C00001238 C00002065	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000619 C00002065 C00003672	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000619 C00002065 C00003672	1 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002065 C00042857	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001238 C00002065	3 / 3
P03372	Estrogen receptor	NR3A1	C00000619 C00003672	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001238 C00002740	0 / 0
Q8NER1	Transient receptor potential cation channel subfamily V member 1	TRPV (Vanilloid)	C00002065 C00042857	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002065 C00002740	4 / 1
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000619 C00001238	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002065 C00042857	4 / 2
O75496	Geminin	Unclassified protein	C00000619 C00042857	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002065 C00002740	7 / 37
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001238 C00003672	1 / 1
P08183	Multidrug resistance protein 1	drug	C00002065 C00003672	1 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000619 C00002065	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00000619 C00002065	0 / 0
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00000619	0 / 0
Q13547	Histone deacetylase 1	Hydrolase	C00042857	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002065	11 / 10
P08047	Transcription factor Sp1	Unclassified protein	C00003672	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000619	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00001238	3 / 1
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002065	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000619	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000619	0 / 1
P17252	Protein kinase C alpha type	Alpha	C00000619	0 / 0
P25021	Histamine H2 receptor	Histamine receptor	C00000619	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000619	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000619	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000619	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000619	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000619	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00035087	0 / 0
P29466	Caspase-1	C14	C00000619	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000619	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000619	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000619	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000619	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000619	1 / 8
P11473	Vitamin D3 receptor	NR1I1	C00001238	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00000619	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000619	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000619	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000619	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000619	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000619	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000619	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000619	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000619	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000619	1 / 0
P06746	DNA polymerase beta	Enzyme	C00003672	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002065	2 / 2
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000619	0 / 0
P15090	Fatty acid-binding protein, adipocyte	Other cytosolic protein	C00001238	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002065	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000619	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000619	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00000619	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00000619	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000619	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000619	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000619	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000619	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000619	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000619	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000619	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000619	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000619	0 / 0
P10145	Interleukin-8	Secreted protein	C00000619	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000619	1 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003672	0 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000619	0 / 0
P08311	Cathepsin G	S1A	C00000619	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000619	1 / 0
P03956	Interstitial collagenase	M10A	C00000619	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000619	0 / 0
Q9UGP5	DNA polymerase lambda	Enzyme	C00001238	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002740	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00000619	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002065	0 / 0
P00734	Prothrombin	S1A	C00003672	4 / 2
P08246	Neutrophil elastase	S1A	C00000619	2 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000619	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000619	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00001238	2 / 2
P14679	Tyrosinase	Oxidoreductase	C00003672	4 / 2
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000619	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000619	2 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002065	5 / 3
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000619	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000619	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000619	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000619	2 / 2
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000619	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000619	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000619	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002740	2 / 0
Q96RI1	Bile acid receptor	NR1H4	C00002065	0 / 0
O15379	Histone deacetylase 3	Hydrolase	C00042857	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00035087	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000619	1 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000619	0 / 3
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000619	2 / 1
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002065	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000619	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002065	2 / 2
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002065	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003672	2 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000619	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000619	2 / 2
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000619	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002065	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000619	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000619	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000619	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000619	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000619	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000619	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000619	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000619	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000619	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00001238	0 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000619	0 / 0
O75795	UDP-glucuronosyltransferase 2B17	Enzyme	C00000619	1 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003672	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000619	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002065	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000619	5 / 1
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000619	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002065	0 / 0
P10275	Androgen receptor	NR3C4	C00000619	3 / 4
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000619	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000619	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000619	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000619	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000619	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000619	0 / 1
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00002065	0 / 0
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000619	0 / 0
Q9UBN7	Histone deacetylase 6	Hydrolase	C00042857	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003672	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00001238	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002065	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000619	3 / 0
O00255	Menin	Unclassified protein	C00001238	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001238	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002740	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002740	1 / 4
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00042857	1 / 1

157 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00000619 C00002740
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00000619 C00001238
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00000619 C00002740
6348	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3	chemokine (C-C motif) ligand 3	C00000619 C00001238
22949	PTGR1, LTB4DH, PGR1, ZADH3	prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74)	C00000619
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00001238
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00002740
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00001238
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00001238
23460	ABCA6, EST155051	ATP-binding cassette, sub-family A (ABC1), member 6	C00000619
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000619
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00000619
57016	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI	aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2)	C00000619
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00000619
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00000619
249	ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP	alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1)	C00000619
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00000619
55114	ARHGAP17, MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH1, RICH1B, WBP15	Rho GTPase activating protein 17	C00000619
10123	ARL4C, ARL7, LAK	ADP-ribosylation factor-like 4C	C00000619
567	B2M	beta-2-microglobulin	C00000619
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000619
9774	BCLAF1, BTF, bK211L9.1	BCL2-associated transcription factor 1	C00000619
654	BMP6, VGR, VGR1	bone morphogenetic protein 6	C00000619
699	BUB1, BUB1A, BUB1L, hBUB1	BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1)	C00000619
57102	C12orf4	chromosome 12 open reading frame 4	C00000619
10203	CALCRL, CGRPR, CRLR	calcitonin receptor-like	C00000619
847	CAT	catalase (EC:1.11.1.6)	C00000619
6357	CCL13, CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1	chemokine (C-C motif) ligand 13	C00000619
6363	CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19	chemokine (C-C motif) ligand 19	C00000619
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00000619
6349	CCL3L1, 464.2, D17S1718, G0S19-2, LD78, LD78BETA, MIP1AP, SCYA3L, SCYA3L1	chemokine (C-C motif) ligand 3-like 1	C00000619
6351	CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4	chemokine (C-C motif) ligand 4	C00000619
729230	CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R	chemokine (C-C motif) receptor 2	C00000619
1234	CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22	chemokine (C-C motif) receptor 5 (gene/pseudogene)	C00000619
1236	CCR7, BLR2, CD197, CDw197, CMKBR7, EBI1	chemokine (C-C motif) receptor 7	C00000619
948	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3	CD36 molecule (thrombospondin receptor)	C00000619
942	CD86, B7-2, B7.2, B70, CD28LG2, LAB72	CD86 molecule	C00000619
1385	CREB1, CREB	cAMP responsive element binding protein 1	C00000619
1390	CREM, CREM-2, ICER, hCREM-2	cAMP responsive element modulator	C00000619
1514	CTSL, CATL, CTSL1, MEP	cathepsin L (EC:3.4.22.15)	C00000619
2919	CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	C00000619
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00000619
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000619
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000619
1593	CYP27A1, CP27, CTX, CYP27	cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15)	C00000619
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00000619
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00000619
1736	DKC1, CBF5, DKC, DKCX, NAP57, NOLA4, XAP101	dyskeratosis congenita 1, dyskerin	C00000619
9787	DLGAP5, DLG7, HURP	discs, large (Drosophila) homolog-associated protein 5	C00000619
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00000619
1870	E2F2, E2F-2	E2F transcription factor 2	C00000619
1871	E2F3, E2F-3	E2F transcription factor 3	C00000619
1874	E2F4, E2F-4	E2F transcription factor 4, p107/p130-binding	C00000619
1875	E2F5, E2F-5	E2F transcription factor 5, p130-binding	C00000619
1876	E2F6, E2F-6	E2F transcription factor 6	C00000619
1959	EGR2, AT591, CMT1D, CMT4E, KROX20	early growth response 2	C00000619
133418	EMB	embigin	C00000619
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000619
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000619
2162	F13A1, F13A	coagulation factor XIII, A1 polypeptide (EC:2.3.2.13)	C00000619
26268	FBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2	F-box protein 9	C00000619
2213	FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2	Fc fragment of IgG, low affinity IIb, receptor (CD32)	C00000619
2235	FECH, EPP, FCE	ferrochelatase (EC:4.99.1.1)	C00000619
2355	FOSL2, FRA2	FOS-like antigen 2	C00000619
2512	FTL, NBIA3	ferritin, light polypeptide	C00000619
2539	G6PD, G6PD1	glucose-6-phosphate dehydrogenase (EC:1.1.1.49)	C00000619
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00000619
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00000619
644076	GLYCAM1	glycosylation dependent cell adhesion molecule 1 (pseudogene)	C00000619
2878	GPX3, GPx-P, GSHPx-3, GSHPx-P	glutathione peroxidase 3 (plasma) (EC:1.11.1.9)	C00000619
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00000619
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00000619
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00000619
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00000619
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00000619
2994	GYPB, CD235b, GPB, GPB.NY, GYPHe.NY, GpMiIII, HGpMiIII, HGpMiVI, HGpMiX, MNS, PAS-3, SS	glycophorin B (MNS blood group)	C00000619
54497	HEATR5B	HEAT repeat containing 5B	C00000619
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00000619
3106	HLA-B, AS, HLAB, SPDA1	major histocompatibility complex, class I, B	C00000619
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000619
220988	HNRNPA3, 2610510D13Rik, D10S102, FBRNP, HNRPA3	heterogeneous nuclear ribonucleoprotein A3	C00000619
3381	IBSP, BNSP, BSP, BSP-II, SP-II	integrin-binding sialoprotein	C00000619
3422	IDI1, IPP1, IPPI1	isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2)	C00000619
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000619
7850	IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB	interleukin 1 receptor, type II	C00000619
3575	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA	interleukin 7 receptor	C00000619
26034	IPCEF1, PIP3-E, RP3-402L9.2	interaction protein for cytohesin exchange factors 1	C00000619
3655	ITGA6, CD49f, ITGA6B, VLA-6	integrin, alpha 6	C00000619
3688	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	C00000619
3741	KCNA5, ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1	potassium voltage-gated channel, shaker-related subfamily, member 5	C00000619
3759	KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3	potassium inwardly-rectifying channel, subfamily J, member 2	C00000619
9493	KIF23, CHO1, KNSL5, MKLP-1, MKLP1	kinesin family member 23	C00000619
23764	MAFF, U-MAF, hMafF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	C00000619
4097	MAFG, hMAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	C00000619
7975	MAFK, NFE2U, P18	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	C00000619
28985	MCTS1, MCT-1, MCT1	malignant T cell amplified sequence 1	C00000619
4199	ME1, HUMNDME, MES	malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40)	C00000619
4257	MGST1, GST12, MGST, MGST-I	microsomal glutathione S-transferase 1 (EC:2.5.1.18)	C00000619
51318	MRPL35, L35mt, MRP-L35	mitochondrial ribosomal protein L35	C00000619
58475	MS4A7, 4SPAN2, CD20L4, CFFM4, MS4A8	membrane-spanning 4-domains, subfamily A, member 7	C00000619
4501	MT1X, MT-1l, MT1	metallothionein 1X	C00000619
4084	MXD1, BHLHC58, MAD, MAD1	MAX dimerization protein 1	C00000619
4602	MYB, Cmyb, c-myb, c-myb_CDS, efg	v-myb avian myeloblastosis viral oncogene homolog	C00000619
10135	NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN	nicotinamide phosphoribosyltransferase (EC:2.4.2.12)	C00000619
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00000619
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00000619
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00000619
4927	NUP88	nucleoporin 88kDa	C00000619
10606	PAICS, ADE2, ADE2H1, AIRC, PAIS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21)	C00000619
5142	PDE4B, DPDE4, PDE4B5, PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	C00000619
5226	PGD, 6PGD	phosphogluconate dehydrogenase (EC:1.1.1.44)	C00000619
8301	PICALM, CALM, CLTH, LAP	phosphatidylinositol binding clathrin assembly protein	C00000619
5327	PLAT, T-PA, TPA	plasminogen activator, tissue (EC:3.4.21.68)	C00000619
5366	PMAIP1, APR, NOXA	phorbol-12-myristate-13-acetate-induced protein 1	C00000619
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00000619
10935	PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III	peroxiredoxin 3 (EC:1.11.1.15)	C00000619
5733	PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R	prostaglandin E receptor 3 (subtype EP3)	C00000619
9619	ABCG1, ABC8, WHITE1	ATP-binding cassette, sub-family G (WHITE), member 1	C00001238
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00000619
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00000619
5996	RGS1, 1R20, BL34, IER1, IR20	regulator of G-protein signaling 1	C00000619
6157	RPL27A, L27A	ribosomal protein L27a	C00000619
50484	RRM2B, MTDPS8A, MTDPS8B, P53R2	ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1)	C00000619
6303	SAT1, DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1	spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57)	C00000619
6383	SDC2, CD362, HSPG, HSPG1, SYND2	syndecan 2	C00000619
55752	SEPT11	septin 11	C00000619
6504	SLAMF1, CD150, CDw150, SLAM	signaling lymphocytic activation molecule family member 1	C00000619
117247	SLC16A10, MCT10, PRO0813, TAT1	solute carrier family 16 (aromatic amino acid transporter), member 10	C00000619
6515	SLC2A3, GLUT3	solute carrier family 2 (facilitated glucose transporter), member 3	C00000619
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00000619
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00000619
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00000619
140809	SRXN1, C20orf139, Npn3, SRX, SRX1	sulfiredoxin 1 (EC:1.8.98.2)	C00000619
6772	STAT1, CANDF7, ISGF-3, STAT91	signal transducer and activator of transcription 1, 91kDa	C00000619
6775	STAT4, SLEB11	signal transducer and activator of transcription 4	C00000619
6777	STAT5B, STAT5	signal transducer and activator of transcription 5B	C00000619
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00000619
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000619
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00000619
7130	TNFAIP6, TSG-6, TSG6	tumor necrosis factor, alpha-induced protein 6	C00000619
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000619
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00000619
162514	TRPV3, OLMS, VRL3	transient receptor potential cation channel, subfamily V, member 3	C00000619
25828	TXN2, MT-TRX, MTRX, TRX2	thioredoxin 2	C00000619
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000619
10587	TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2	thioredoxin reductase 2 (EC:1.8.1.9)	C00000619
7358	UGDH, GDH, UDP-GlcDH, UDPGDH, UGD	UDP-glucose 6-dehydrogenase (EC:1.1.1.22)	C00000619
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00000619
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00000619
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00000619
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00000619
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00000619
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00000619
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00000619
7367	UGT2B17, BMND12, UDPGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17)	C00000619
7421	VDR, NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	C00000619
7709	ZBTB17, MIZ-1, ZNF151, ZNF60, pHZ-67	zinc finger and BTB domain containing 17	C00000619

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