Populus trichocarpa
Species
KNApSAcK Entry
| Organism name | Populus trichocarpa |
|---|---|
| Genus | Populus |
| Family | Salicaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Populus trichocarpa |
|---|---|
| Linked NCBI taxonomy ID | 3694 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Salicaceae |
|---|---|
| ID | 3688 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007939
|
Calomelanone
|
No. 90 | No. 13 |
|
||||
|
C00007937
|
2',4',6'-Trihydroxy-4-methoxydihydrochalcone
|
No. 90 | No. 13 |
|
||||
|
C00006953
|
Neosakuranetin
|
No. 92 | No. 13 |
|
||||
|
C00006952
|
2',4',6'-Trihydroxy-4-methoxychalcone
|
CHEMBL133588
|
No. 92 | No. 13 |
|
|||
|
C00000660
|
Feruloyl tyramine
|
CHEMBL206555
CHEMBL451720 |
C074004
|
1 / 4 / 2 | No. 499 |
|
||
|
C00000662
|
Caffeoyl tyramine
|
CHEMBL206646
|
1 / 4 / 2 | No. 499 |
|
|||
|
C00000661
|
N-trans-Sinapoyltyramine
|
CHEMBL226587
|
No. 499 |
|
||||
|
C00002677
|
Trichocarpin
|
No. 532 |
|
|||||
|
C00007936
|
Phloretin
|
CHEMBL45068
|
D010693
|
47 / 63 / 81 | 13 / 0 | No. 548 | No. 13 |
|
Human Protein / Gene in interactions
48 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P14679 | Tyrosinase | Oxidoreductase | C00000660 C00000662 | 4 / 2 |
| Q12791 | Calcium-activated potassium channel subunit alpha-1 | KCNM, KCa1.x | C00007936 | 1 / 1 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00007936 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00007936 | 7 / 37 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00007936 | 2 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00007936 | 2 / 2 |
| P06746 | DNA polymerase beta | Enzyme | C00007936 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00007936 | 6 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00007936 | 1 / 1 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00007936 | 1 / 4 |
| Q9HAS3 | Solute carrier family 28 member 3 | Unclassified protein | C00007936 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00007936 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00007936 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00007936 | 3 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00007936 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00007936 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00007936 | 1 / 8 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00007936 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00007936 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00007936 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00007936 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00007936 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00007936 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00007936 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00007936 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00007936 | 1 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00007936 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00007936 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00007936 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00007936 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00007936 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00007936 | 2 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00007936 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00007936 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00007936 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00007936 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00007936 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00007936 | 4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00007936 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00007936 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00007936 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00007936 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00007936 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00007936 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00007936 | 2 / 5 |
| O15427 | Monocarboxylate transporter 4 | Unclassified protein | C00007936 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00007936 | 0 / 0 |
| Q9HCT0 | Fibroblast growth factor 22 | Unclassified protein | C00007936 | 0 / 0 |
13 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00007936
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00007936
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00007936
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00007936
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00007936
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00007936
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00007936
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00007936
|
| 6548 | SLC9A1, APNH, NHE-1, NHE1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 |
C00007936
|
| 133308 | SLC9B2, NHA2, NHE10, NHEDC2 | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 |
C00007936
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00007936
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00007936
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00007936
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (67)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #609446 | Generalized epilepsy and paroxysmal dyskinesia; gepd |
Q12791
|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG DISEASE (82)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H01258 | Generalized epilepsy and paroxysmal dyskinesia (GEPD) |
Q12791
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|