PCIDB

Mitragyna speciosa Korth.

Species

KNApSAcK Entry

Organism name Mitragyna speciosa Korth.
Genus Mitragyna
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Mitragyna speciosa
Linked NCBI taxonomy ID 170351
Linked level species

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (8)

Species Activity
Mitragyna speciosa Korth. Analgesic
Mitragyna speciosa Korth. Anesthetic
Mitragyna speciosa Korth. Antitussive
Mitragyna speciosa Korth. CNS-Stimulant
Mitragyna speciosa Korth. Fumitory
Mitragyna speciosa Korth. Hallucinogen
Mitragyna speciosa Korth. Masticatory
Mitragyna speciosa Korth. Narcotic

Metabolite list (23)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025220 External link 512 Uncarin D
/ Uncarine D
/ Speciophylline
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
C104393
8 / 14 / 9 No. 154
C00025158 External link 512 Ciliaphylline
No. 154
C00025212 External link 512 Specionoxeine
No. 154
C00025162 External link 512 Corynoxeine
CHEMBL481358
CHEMBL481359
C054799
No. 154
C00025163 External link 512 Corynoxine
CHEMBL519266
CHEMBL480521
CHEMBL1909423
CHEMBL1909424
2 / 2 / 2 No. 154
C00025164 External link 512 Corynoxine B
CHEMBL519266
CHEMBL480521
CHEMBL1909423
CHEMBL1909424
2 / 2 / 2 No. 154
C00025210 External link 512 Speciofoline
No. 154
C00025180 External link 512 Isomitrafoline
No. 154
C00025181 External link 512 Isomitraphylline
/ Ajmalicine oxindole A
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
8 / 14 / 9 No. 154
C00025208 External link 512 Rhynchociline
/ Rhynchocilin
No. 154
C00025184 External link 512 Isorhynchophylline
/ (+/-)-Isorhynchophylline
CHEMBL519266
CHEMBL480521
CHEMBL1909423
CHEMBL1909424
2 / 2 / 2 No. 154
C00025190 External link 512 Mitragynine oxindole B
No. 154
C00025188 External link 512 Mitragynol
/ Mitrafoline
No. 154
C00025189 External link 512 Mitragynine oxindole A
No. 154
C00025185 External link 512 Javaphylline
No. 154
C00025191 External link 512 Mitrajavine
No. 246 No. 4
C00025194 External link 512 Paynantheine
/ Indolo[2,3-a]quinolizine
No. 246 No. 4
C00025182 External link 512 Isopaynantheine
/ 3-Isopaynantheine
No. 246 No. 4
C00025209 External link 512 Speciociliatin
/ Speciociliatine
CHEMBL58496
CHEMBL299031
CHEMBL107364
1 / 0 / 0 No. 246 No. 4
C00025179 External link 512 Isocorynantheidine
CHEMBL60533
CHEMBL327134
CHEMBL1668781
CHEMBL1668783
2 / 0 / 0 No. 246 No. 4
C00025211 External link 512 Speciogynin
/ Speciogynine
CHEMBL58496
CHEMBL299031
CHEMBL107364
1 / 0 / 0 No. 246 No. 4
C00025161 External link 512 Corynantheidine
CHEMBL60533
CHEMBL327134
CHEMBL1668781
CHEMBL1668783
2 / 0 / 0 No. 246 No. 4
C00025145 External link 512 3-Isoajmalicine
CHEMBL122404
CHEMBL123325
CHEMBL498734
CHEMBL486933
CHEMBL1604074
CHEMBL2079609
32 / 28 / 31 No. 246 No. 4

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P41143 Delta-type opioid receptor Opioid receptor C00025161 C00025179 C00025209 C00025211 0 / 0
P42858 Huntingtin Unclassified protein C00025145 C00025181 C00025220 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00025163 C00025164 C00025184 2 / 2
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00025163 C00025164 C00025184 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00025181 C00025220 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00025181 C00025220 1 / 2
P10253 Lysosomal alpha-glucosidase Hydrolase C00025181 C00025220 1 / 1
P37840 Alpha-synuclein Unclassified protein C00025181 C00025220 4 / 2
O75496 Geminin Unclassified protein C00025181 C00025220 0 / 0
P06276 Cholinesterase Hydrolase C00025161 C00025179 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00025181 C00025220 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025181 C00025220 7 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025145 1 / 0
P68871 Hemoglobin subunit beta Secreted protein C00025145 4 / 4
P17405 Sphingomyelin phosphodiesterase Enzyme C00025145 2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00025145 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00025145 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025145 0 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00025145 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00025145 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025145 11 / 10
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025145 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025145 0 / 0
P29466 Caspase-1 C14 C00025145 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00025145 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00025145 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025145 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025145 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00025145 3 / 3
P55210 Caspase-7 C14 C00025145 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025145 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025145 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00025145 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025145 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00025145 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025145 0 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein C00025145 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025145 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025145 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025145 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025145 0 / 0
O00255 Menin Unclassified protein C00025145 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025145 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#612219 Ewing sarcoma; es P11308
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (41)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00020 Colorectal cancer P68871 (marker)
H00022 Bladder cancer P68871 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)