PCIDB

KNApSAcK Metabolite C00025181

Metabolite

KNApSAcK Entry

id C00025181
Name Isomitraphylline / Ajmalicine oxindole A
CAS RN 4963-01-3
Standard InChI InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14+,18-,21-/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)

Cluster

Phytochemical cluster
KCF-S cluster No. 154

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL562222 CHEMBL1449034 CHEMBL1886339 CHEMBL2135897 CHEMBL2307077 CHEMBL2355088

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1449034 CHEMBL1614103 (1) CHEMBL1614031 (1)
1 / 1
P37840 Alpha-synuclein Unclassified protein CHEMBL1449034 CHEMBL2354282 (1)
4 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1449034 CHEMBL1614458 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL1449034 CHEMBL1613918 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL562222 CHEMBL1449034 CHEMBL2114843 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL562222 CHEMBL2114810 (1)
7 / 3
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL1886339 CHEMBL2114924 (1)
1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL562222 CHEMBL1449034 CHEMBL1794401 (2)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#127750 Dementia, lewy body; dlb P37840
#612219 Ewing sarcoma; es P11308
#232300 Glycogen storage disease ii P10253
#143100 Huntington disease; hd P42858
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092

KEGG DISEASE (9)

KEGG disease name UniProt
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)