Species

KNApSAcK Entry

Organism name Mitragyna hirsuta Havil
Genus Mitragyna
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Mitragyna
Linked NCBI taxonomy ID 170021
Linked level genus

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025222 External link 512 Uncarine F
/ Speciofiline
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
8 / 14 / 9 No. 154
C00025220 External link 512 Uncarin D
/ Uncarine D
/ Speciophylline
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
C104393
8 / 14 / 9 No. 154
C00025219 External link 512 Uncarine C
/ allo-Pteropodine
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
8 / 14 / 9 No. 154
C00025181 External link 512 Isomitraphylline
/ Ajmalicine oxindole A
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
8 / 14 / 9 No. 154
C00025221 External link 512 Uncarine E
/ 7-Isopteropodine
/ allo-Isopteropodine
CHEMBL562222
CHEMBL1449034
CHEMBL1886339
CHEMBL2135897
CHEMBL2307077
CHEMBL2355088
8 / 14 / 9 No. 154
C00025184 External link 512 Isorhynchophylline
/ (+/-)-Isorhynchophylline
CHEMBL519266
CHEMBL480521
CHEMBL1909423
CHEMBL1909424
2 / 2 / 2 No. 154
C00025175 External link 512 Hirsutine
/ Hirsutine(Mitragyna)
CHEMBL60533
CHEMBL327134
CHEMBL1668781
CHEMBL1668783
C038369
2 / 0 / 0 No. 246 No. 4
C00025174 External link 512 Hirsuteine
/ 3-Epicorynantheine
CHEMBL326900
No. 246 No. 4
C00025191 External link 512 Mitrajavine
No. 246 No. 4
C00025154 External link 512 Angustoline
/ (-)-Angustoline
C004167
No. 1009 No. 7

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00025181 C00025219 C00025220 C00025221 C00025222 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025181 C00025219 C00025220 C00025221 C00025222 1 / 1
P37840 Alpha-synuclein Unclassified protein C00025181 C00025219 C00025220 C00025221 C00025222 4 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00025181 C00025219 C00025220 C00025221 C00025222 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00025181 C00025219 C00025220 C00025221 C00025222 0 / 0
P42858 Huntingtin Unclassified protein C00025181 C00025219 C00025220 C00025221 C00025222 1 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00025181 C00025219 C00025220 C00025221 C00025222 1 / 2
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025181 C00025219 C00025220 C00025221 C00025222 7 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00025184 2 / 2
P41143 Delta-type opioid receptor Opioid receptor C00025175 0 / 0
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00025184 0 / 0
P06276 Cholinesterase Hydrolase C00025175 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#127750 Dementia, lewy body; dlb P37840
#612219 Ewing sarcoma; es P11308
#232300 Glycogen storage disease ii P10253
#143100 Huntington disease; hd P42858
#613688 Long qt syndrome 2; lqt2 Q12809
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#609620 Short qt syndrome 1; sqt1 Q12809

KEGG DISEASE (11)

KEGG name UniProt
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)