Uncaria tomentosa

• Index
• Plant Species
• Natural Activity
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Uncaria tomentosa
Genus	Uncaria
Family	Rubiaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Uncaria tomentosa
Linked NCBI taxonomy ID	128375
Linked level	species

Family

Family in NCBI taxonomy	Rubiaceae
ID	24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Natural Activity

List (88)

Species	Activity
Uncaria tomentosa (Willd. Ex Schult.) DC.	5-Lipoxygenase Inhibitor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Analgesic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Anti-HIV
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiaggregant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiaggregant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antialzheimeran
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiamyloidosis
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiapoptotic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiarrhythmic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiarthritic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antibacterial
Uncaria tomentosa (Willd. Ex Schult.) DC.	Anticoagulant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antidepressant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antidiabetic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antidysenteric
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiedemic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiedemic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antifertility
Uncaria tomentosa (Willd. Ex Schult.) DC.	AntiHIV
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antihypertensive
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiinflammatory
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiinflammatory
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antileukemic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antileukemic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antimelanomic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antimelanomic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antimetastatic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antimutagenic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antimutagenic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antioxidant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antioxidant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiprogesteronic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiproliferant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiprostaglandin
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antipyretic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiradicular
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiradicular
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antirheumatic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antirhinoviral
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antirhinoviral
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antisarcomic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antisarcomic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antistomatitic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antistomatitic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antithrombic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antithrombic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antitumor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antitumor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiulcer
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiviral
Uncaria tomentosa (Willd. Ex Schult.) DC.	Antiviral
Uncaria tomentosa (Willd. Ex Schult.) DC.	Aphrodisiac
Uncaria tomentosa (Willd. Ex Schult.) DC.	Apoptotic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Apoptotic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Bactericide
Uncaria tomentosa (Willd. Ex Schult.) DC.	Calcium Antagonist
Uncaria tomentosa (Willd. Ex Schult.) DC.	Calcium-Antagonist
Uncaria tomentosa (Willd. Ex Schult.) DC.	Contraceptive
Uncaria tomentosa (Willd. Ex Schult.) DC.	Contraceptive
Uncaria tomentosa (Willd. Ex Schult.) DC.	COX-2-Inhibitor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Cyclooxygenase-Inhibitor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Cytoprotective
Uncaria tomentosa (Willd. Ex Schult.) DC.	Cytostat
Uncaria tomentosa (Willd. Ex Schult.) DC.	Cytostatic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Depurative
Uncaria tomentosa (Willd. Ex Schult.) DC.	Detoxicant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Diuretic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Dopaminergic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Dopaminergic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Estrogen-Agonist
Uncaria tomentosa (Willd. Ex Schult.) DC.	Febrifuge
Uncaria tomentosa (Willd. Ex Schult.) DC.	Gastroprotective
Uncaria tomentosa (Willd. Ex Schult.) DC.	Hypocholesterolemic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Hypotensive
Uncaria tomentosa (Willd. Ex Schult.) DC.	Hypotensive
Uncaria tomentosa (Willd. Ex Schult.) DC.	Immunostimulant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Immunostimulant
Uncaria tomentosa (Willd. Ex Schult.) DC.	Interleukinogenic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Interleukinogenic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Leukocytogenic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Mutagenic
Uncaria tomentosa (Willd. Ex Schult.) DC.	NF-kB-Inhibitor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Phagocytotic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Phagocytotic
Uncaria tomentosa (Willd. Ex Schult.) DC.	TNF-Inhibitor
Uncaria tomentosa (Willd. Ex Schult.) DC.	Tonic
Uncaria tomentosa (Willd. Ex Schult.) DC.	Vasodilator
Uncaria tomentosa (Willd. Ex Schult.) DC.	Vulnerary

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00045111	Tomentoside B / (-)-Tomentoside B					No. 9	No. 51
C00045110	Tomentoside A / (-)-Tomentoside A					No. 9	No. 51
C00036651	7-Deoxyloganic acid		C468757			No. 64	No. 36
C00030536	Isomitraphylline N-oxide					No. 154
C00025221	Uncarine E / 7-Isopteropodine / allo-Isopteropodine	CHEMBL562222 CHEMBL1449034 CHEMBL1886339 CHEMBL2135897 CHEMBL2307077 CHEMBL2355088		8 / 14 / 9		No. 154
C00025220	Uncarin D / Uncarine D / Speciophylline	CHEMBL562222 CHEMBL1449034 CHEMBL1886339 CHEMBL2135897 CHEMBL2307077 CHEMBL2355088	C104393	8 / 14 / 9		No. 154
C00025181	Isomitraphylline / Ajmalicine oxindole A	CHEMBL562222 CHEMBL1449034 CHEMBL1886339 CHEMBL2135897 CHEMBL2307077 CHEMBL2355088		8 / 14 / 9		No. 154
C00025219	Uncarine C / allo-Pteropodine	CHEMBL562222 CHEMBL1449034 CHEMBL1886339 CHEMBL2135897 CHEMBL2307077 CHEMBL2355088		8 / 14 / 9		No. 154
C00001752	Mitraphylline	CHEMBL562222 CHEMBL1449034 CHEMBL1886339 CHEMBL2135897 CHEMBL2307077 CHEMBL2355088		8 / 14 / 9		No. 154
C00032658	5(S)-5-Carboxystrictosidine	CHEMBL503313 CHEMBL502463				No. 618	No. 4
C00030696	Lyaloside					No. 934

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001752 C00025181 C00025219 C00025220 C00025221	1 / 1
P37840	Alpha-synuclein	Unclassified protein	C00001752 C00025181 C00025219 C00025220 C00025221	4 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00001752 C00025181 C00025219 C00025220 C00025221	0 / 0
P42858	Huntingtin	Unclassified protein	C00001752 C00025181 C00025219 C00025220 C00025221	1 / 1
O75496	Geminin	Unclassified protein	C00001752 C00025181 C00025219 C00025220 C00025221	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001752 C00025181 C00025219 C00025220 C00025221	7 / 3
P11308	Transcriptional regulator ERG	Unclassified protein	C00001752 C00025181 C00025219 C00025220 C00025221	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00001752 C00025181 C00025219 C00025220 C00025221	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions