Organism name | Citrus unshiu Marc. |
---|---|
Genus | Citrus |
Family | Rutaceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Citrus |
---|---|
Linked NCBI taxonomy ID | 2706 |
Linked level | genus |
Family in NCBI taxonomy | Rutaceae |
---|---|
ID | 23513 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | rosids |
---|---|
ID | 71275 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00000823 |
Limonene
|
CHEMBL15799
CHEMBL449062 |
C008281
|
7 / 21 / 48 | 6 / 6 | No. 848 | No. 35 | |
C00003047 |
Linalool
/ (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol |
CHEMBL25306
CHEMBL235672 |
C018584
|
6 / 8 / 2 | 35 / 4 | No. 958 | No. 34 | |
C00007453 |
Cyclohexane
/ beta-Elemene |
CHEMBL448502
CHEMBL479707 |
No. 1400 | |||||
C00000853 |
Myrcene
|
CHEMBL455491
|
C008574
|
3 / 3 / 3 | No. 2285 | No. 34 | ||
C00000861 |
Terpinolene
|
CHEMBL454697
|
C027009
|
1 / 0 | No. 3725 |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
P10828 | Thyroid hormone receptor beta | NR1A2 | C00000823 C00003047 | 3 / 1 |
P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000823 | 0 / 0 |
P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000823 | 0 / 3 |
Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000823 | 0 / 0 |
P02545 | Prelamin-A/C | Unclassified protein | C00000823 | 11 / 10 |
P16473 | Thyrotropin receptor | Glycohormone receptor | C00000853 | 3 / 2 |
P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003047 | 3 / 0 |
P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000823 | 7 / 37 |
P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003047 | 0 / 0 |
P04150 | Glucocorticoid receptor | NR3C1 | C00000853 | 0 / 1 |
Q96RI1 | Bile acid receptor | NR1H4 | C00000853 | 0 / 0 |
Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00003047 | 0 / 0 |
P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003047 | 0 / 0 |
P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003047 | 5 / 1 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000823 | 0 / 0 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000823
C00003047
|
207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000861
C00003047
|
7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000823
C00003047
|
4852 | NPY, PYY4 | neuropeptide Y |
C00000823
C00003047
|
2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00003047
|
3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000823
|
1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00003047
|
596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000823
|
1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00003047
|
329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003047
|
330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00003047
|
1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003047
|
1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00003047
|
1028 | CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
C00003047
|
1030 | CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
C00003047
|
1447 | CSN2, CASB | casein beta |
C00003047
|
1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00003047
|
1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00003047
|
1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003047
|
3265 | HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 | Harvey rat sarcoma viral oncogene homolog |
C00000823
|
1647 | GADD45A, DDIT1, GADD45 | growth arrest and DNA-damage-inducible, alpha |
C00003047
|
2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00003047
|
3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003047
|
3297 | HSF1, HSTF1 | heat shock transcription factor 1 |
C00003047
|
3320 | HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
C00003047
|
3308 | HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY | heat shock 70kDa protein 4 |
C00003047
|
3316 | HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP | heat shock 27kDa protein 2 |
C00003047
|
3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00003047
|
3638 | INSIG1, CL-6, CL6 | insulin induced gene 1 |
C00003047
|
3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003047
|
8850 | KAT2B, CAF, P, P/CAF, PCAF | K(lysine) acetyltransferase 2B (EC:2.3.1.48) |
C00003047
|
4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00003047
|
4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003047
|
4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003047
|
100124292 |
C00003047
|
||
7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00003047
|
7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00003047
|
26118 | WSB1, SWIP1, WSB-1 | WD repeat and SOCS box containing 1 |
C00003047
|
OMIM | preferred title | UniProt |
---|---|---|
#202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
#614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
#601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
#115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
#212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
#605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
#218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
#606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
#181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
#133239 | Esophageal cancer |
P04637
|
#143500 | Gilbert syndrome |
P22309
P22310 |
#610140 | Heart-hand syndrome, slovenian type |
P02545
|
#176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
#237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
#603373 | Hyperthyroidism, familial gestational |
P16473
|
#609152 | Hyperthyroidism, nonautoimmune |
P16473
|
#275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
#151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
#151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
#211980 | Lung cancer |
P04637
|
#248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
#613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
#159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
#260500 | Papilloma of choroid plexus; cpp |
P04637
|
#275210 | Restrictive dermopathy, lethal |
P02545
|
#275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
#188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
#274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
#145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG | name | UniProt |
---|---|---|
H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
H00663 | Restrictive dermopathy |
P02545
(related)
|
H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
H00006 | Hairy-cell leukemia |
P04637
(related)
|
H00008 | Burkitt lymphoma |
P04637
(related)
|
H00009 | Adult T-cell leukemia |
P04637
(related)
|
H00010 | Multiple myeloma |
P04637
(related)
|
H00013 | Small cell lung cancer |
P04637
(related)
|
H00014 | Non-small cell lung cancer |
P04637
(related)
|
H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
H00018 | Gastric cancer |
P04637
(related)
|
H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
H00022 | Bladder cancer |
P04637
(related)
|
H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
H00026 | Endometrial Cancer |
P04637
(related)
|
H00027 | Ovarian cancer |
P04637
(related)
|
H00028 | Choriocarcinoma |
P04637
(related)
|
H00029 | Vulvar cancer |
P04637
(related)
|
H00031 | Breast cancer |
P04637
(related)
|
H00032 | Thyroid cancer |
P04637
(related)
|
H00033 | Adrenal carcinoma |
P04637
(related)
|
H00036 | Osteosarcoma |
P04637
(related)
|
H00038 | Malignant melanoma |
P04637
(related)
|
H00039 | Basal cell carcinoma |
P04637
(related)
|
H00040 | Squamous cell carcinoma |
P04637
(related)
|
H00041 | Kaposi's sarcoma |
P04637
(related)
|
H00042 | Glioma |
P04637
(related)
P04637 (marker) |
H00044 | Cancer of the anal canal |
P04637
(related)
|
H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
H00047 | Gallbladder cancer |
P04637
(related)
|
H00048 | Hepatocellular carcinoma |
P04637
(related)
|
H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
H01007 | Choroid plexus papilloma |
P04637
(related)
|
H00021 | Renal cell carcinoma |
P04637
(marker)
|
H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
H01269 | Congenital hyperthyroidism |
P16473
(related)
|
H00208 | Hyperbilirubinemia |
P22309
(related)
|
MESH or OMIM | name |
KNApSAcK
metabolite |
---|---|---|
D003877 | Dermatitis, Contact |
C00000823
|
D007674 | Kidney Diseases |
C00000823
|
D008107 | Liver Diseases |
C00000823
|
D008114 | Liver Neoplasms, Experimental |
C00000823
|
D008569 | Memory Disorders |
C00000823
|
D013276 | Stomach Ulcer |
C00000823
|
D017453 | Dermatitis, Irritant |
C00003047
|
D006937 | Hypercholesterolemia |
C00003047
|
D007938 | Leukemia |
C00003047
|
D009369 | Neoplasms |
C00003047
|