Species

KNApSAcK Entry

Organism name Erythrina sacleuxii
Genus Erythrina
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Erythrina
Linked NCBI taxonomy ID 3841
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019020 External link 512 5'-Formylpratensein
/ 5,7,3'-Trihydroxy-4'-methoxy-5'-formylisoflavone
No. 3 No. 15
C00019017 External link 512 7-Demethylrobustigenin
/ 5,7-Dihydroxy-2',4',5'-trimethoxyisoflavone
CHEMBL1087519
No. 3 No. 15
C00009502 External link 512 2,3-Dehydrokievitone
/ 5,7,2',4'-Tetrahydroxy-8-prenylisoflavone
No. 15 No. 15
C00019019 External link 512 5,7,3'-Trihydroxy-4'-methoxy-5'-prenylisoflavone
No. 15 No. 15
C00019018 External link 512 5,7-Dihydroxy-4'-methoxy-3'-prenylisoflavone
No. 15 No. 15
C00014175 External link 512 Abyssinone V 4'-methyl ether
/ 5,7-Dihydroxy-4'-methoxy-3',5'-diprenylflavanone
CHEMBL470249
CHEMBL1425525
20 / 20 / 13 No. 19 No. 14
C00000936 External link 512 Abyssinone V
CHEMBL255890
CHEMBL454332
C056679
2 / 0 / 0 No. 19 No. 14
C00008456 External link 512 4'-Methylsigmoidin B
C055273
No. 28 No. 14
C00018977 External link 512 (R)-5,7-Dihydroxy-2',4',5'-trimethoxyisoflavanone
No. 106 No. 14
C00018979 External link 512 Shinpterocarpin
CHEMBL591773
1 / 5 / 3 No. 135 No. 15
C00018980 External link 512 Erythrinasinate
No. 447
C00018978 External link 512 (R)-Saclenone
/ (R)-5-Hydroxy-2',4',5'-trimethoxy-2'',2''-dimethylpyrano[5'',6'':6,7]isoflavanone
No. 589 No. 15

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000936 C00014175 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00014175 1 / 2
Q99700 Ataxin-2 Unclassified protein C00014175 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00014175 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00014175 1 / 4
P39748 Flap endonuclease 1 Enzyme C00014175 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00014175 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00014175 2 / 0
O75496 Geminin Unclassified protein C00014175 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00014175 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00014175 7 / 3
P17861 X-box-binding protein 1 Unclassified protein C00014175 1 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00018979 5 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00014175 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00014175 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00014175 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00014175 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00014175 0 / 0
P04054 Phospholipase A2 Enzyme C00000936 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00014175 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00014175 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00014175 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (16)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)