Species

KNApSAcK Entry

Organism name Kandelia candel
Genus Kandelia
Family Rhizophoraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Kandelia candel
Linked NCBI taxonomy ID 61147
Linked level species

Family

Family in NCBI taxonomy Rhizophoraceae
ID 40029

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002906 External link 512 Afzelechin-(4alpha->8)-afzelechin
No. 16 No. 19
C00009058 External link 512 Afzelechin-(4alpha->8)-catechin
No. 16 No. 19
C00009186 External link 512 Cinchonanin IIa
/ Cinchonain-1a-(4beta->8)-epicatechin
CHEMBL491581
No. 29 No. 19
C00002929 External link 512 Kandelin A1
/ Cinchonain-1a-(4beta->8)-catechin
CHEMBL491581
No. 29 No. 19
C00009291 External link 512 Cinnamtannin B1
CHEMBL540956
CHEMBL81478
CHEMBL445468
CHEMBL1213875
CHEMBL1213876
14 / 4 / 7 No. 29 No. 19
C00009098 External link 512 Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin
CHEMBL290632
13 / 5 / 6 No. 29 No. 19
C00009087 External link 512 Epicatechin-(4beta->6)-epicatechin-(4beta->8)-epicatechin
CHEMBL592228
2 / 3 / 4 No. 29 No. 19
C00009084 External link 512 [Epicatechin-(4beta->6)]2-epicatechin
No. 29 No. 19
C00009086 External link 512 Epicatechin-(4beta->6)-epicatechin-(4beta->8)-catechin
CHEMBL592228
2 / 3 / 4 No. 29 No. 19
C00000937 External link 512 Afzelechin
CHEMBL159303
CHEMBL1326092
7 / 4 / 12 No. 52 No. 14
C00008817 External link 512 Gallocatechin
/ (+)-Gallocatechin
/ (+)-Gallocatechol
/ (2R,3S)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol
CHEMBL47386
CHEMBL125743
CHEMBL130415
CHEMBL264167
CHEMBL404845
26 / 17 / 29 No. 52 No. 14
C00009188 External link 512 Kandelin B4
/ Cinchonain-1b-(4beta->8)-epicatechin-(4beta->8)-catechin
No. 113 No. 19
C00009101 External link 512 Kandelin B3
No. 113 No. 19
C00009187 External link 512 Kandelin B1
/ Cinchonain-1a-(4beta->8)-epicatechin-(4beta->8)-epicatechin
No. 113 No. 19
C00008964 External link 512 Cinchonain Ib
CHEMBL401058
CHEMBL251476
No. 444
C00002913 External link 512 Cinchonain Ia
CHEMBL401058
CHEMBL251476
No. 444
C00038888 External link 512 Cyclo-(Leu-Tyr)
/ (+)-Cyclo-(Leu-Tyr)
No. 2431
C00038887 External link 512 Cyclo-(Leu-Leu)
/ Cyclo(leucylleucine)
C007199
No. 4490

Human Protein / Gene in interactions

45 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000937 C00008817 C00009291 0 / 3
P14780 Matrix metalloproteinase-9 M10A C00009086 C00009087 C00009098 2 / 2
P08253 72 kDa type IV collagenase M10A C00009086 C00009087 C00009098 1 / 3
P24723 Protein kinase C eta type Eta C00009098 C00009291 1 / 0
P05771 Protein kinase C beta type Alpha C00009098 C00009291 0 / 0
P05129 Protein kinase C gamma type Alpha C00009098 C00009291 1 / 1
Q05655 Protein kinase C delta type Delta C00009098 C00009291 0 / 0
P41743 Protein kinase C iota type Iota C00009098 C00009291 0 / 0
P17252 Protein kinase C alpha type Alpha C00009098 C00009291 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00009098 C00009291 0 / 0
Q02156 Protein kinase C epsilon type Eta C00009098 C00009291 0 / 0
Q04759 Protein kinase C theta type Delta C00009098 C00009291 0 / 1
Q05513 Protein kinase C zeta type Iota C00009098 C00009291 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000937 C00008817 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000937 C00008817 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00009098 C00009291 0 / 0
P56817 Beta-secretase 1 A1A C00008817 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00008817 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00008817 2 / 2
P00374 Dihydrofolate reductase Oxidoreductase C00008817 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00008817 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00008817 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00008817 2 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00008817 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00008817 4 / 3
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00008817 0 / 7
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00009291 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00008817 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00008817 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00008817 1 / 1
O00255 Menin Unclassified protein C00000937 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000937 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00008817 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00008817 1 / 4
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00008817 0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00000937 1 / 1
P41143 Delta-type opioid receptor Opioid receptor C00008817 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00008817 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00008817 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00008817 2 / 3
Q06187 Tyrosine-protein kinase BTK Tec C00009291 2 / 2
P02768 Serum albumin Secreted protein C00008817 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00008817 1 / 1
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00008817 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000937 0 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300755 Agammaglobulinemia, x-linked; xla Q06187
#119900 Digital clubbing, isolated congenital P15428
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989

KEGG DISEASE (42)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00028 Choriocarcinoma P08253 (related)
P10415 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00017 Esophageal cancer P35354 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00014 Non-small cell lung cancer Q9UM73 (related)