PCIDB

Panax ginseng

Species

KNApSAcK Entry

Organism name Panax ginseng
Genus Panax
Family Araliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Panax ginseng
Linked NCBI taxonomy ID 4054
Linked level species

Family

Family in NCBI taxonomy Araliaceae
ID 4050

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (93)

Species Activity
Panax ginseng C.A. Mey. Adaptogen
Panax ginseng C.A. Mey. Adrenergic
Panax ginseng C.A. Mey. Alterative
Panax ginseng C.A. Mey. Analgesic
Panax ginseng C.A. Mey. Antiaggregant
Panax ginseng C.A. Mey. Antiaging
Panax ginseng C.A. Mey. Antialcoholic
Panax ginseng C.A. Mey. Antiarrhythmic
Panax ginseng C.A. Mey. Anticancer
Panax ginseng C.A. Mey. Anticatecholamine
Panax ginseng C.A. Mey. Anticholinergic
Panax ginseng C.A. Mey. Anticonvulsant
Panax ginseng C.A. Mey. Antidepressant
Panax ginseng C.A. Mey. Antidiuretic
Panax ginseng C.A. Mey. Antifatigue
Panax ginseng C.A. Mey. Antihepatomic
Panax ginseng C.A. Mey. Antiinflammatory
Panax ginseng C.A. Mey. Antiischemic
Panax ginseng C.A. Mey. Antimitogenic
Panax ginseng C.A. Mey. Antioxidant
Panax ginseng C.A. Mey. Antiprolactin
Panax ginseng C.A. Mey. Antiprostatic
Panax ginseng C.A. Mey. Antipsychotic
Panax ginseng C.A. Mey. Antiradiation
Panax ginseng C.A. Mey. Antiseptic
Panax ginseng C.A. Mey. Antithromboxane
Panax ginseng C.A. Mey. Antitumor
Panax ginseng C.A. Mey. Antiulcer
Panax ginseng C.A. Mey. Antiviral
Panax ginseng C.A. Mey. Antiwrinkle
Panax ginseng C.A. Mey. Anxiolytic
Panax ginseng C.A. Mey. Aperitif
Panax ginseng C.A. Mey. Aphrodisiac
Panax ginseng C.A. Mey. Apoptotic
Panax ginseng C.A. Mey. Bitter
Panax ginseng C.A. Mey. Cardiotonic
Panax ginseng C.A. Mey. Carminative
Panax ginseng C.A. Mey. Caspase Stimulator
Panax ginseng C.A. Mey. Chemopreventive
Panax ginseng C.A. Mey. Circulostimulant
Panax ginseng C.A. Mey. CNS Sedative
Panax ginseng C.A. Mey. CNS Stimulant
Panax ginseng C.A. Mey. Corticotrophinogenic
Panax ginseng C.A. Mey. Cytotoxic
Panax ginseng C.A. Mey. Demulcent
Panax ginseng C.A. Mey. Diuretic
Panax ginseng C.A. Mey. Elevates HDL-Cholesterol
Panax ginseng C.A. Mey. Emetic
Panax ginseng C.A. Mey. Energizer
Panax ginseng C.A. Mey. Estrogenic
Panax ginseng C.A. Mey. Ethanolytic
Panax ginseng C.A. Mey. Expectorant
Panax ginseng C.A. Mey. Fatigue
Panax ginseng C.A. Mey. Gonadotropic
Panax ginseng C.A. Mey. Hemopoietic
Panax ginseng C.A. Mey. Hepatoprotective
Panax ginseng C.A. Mey. Hepatotonic
Panax ginseng C.A. Mey. Hyperglycemic
Panax ginseng C.A. Mey. Hypertensive
Panax ginseng C.A. Mey. Hypocholesterolemic
Panax ginseng C.A. Mey. Hypoglycemic
Panax ginseng C.A. Mey. Hypotriglyceridemic
Panax ginseng C.A. Mey. Immunostimulant
Panax ginseng C.A. Mey. Interferonigenic
Panax ginseng C.A. Mey. Memorigenic
Panax ginseng C.A. Mey. Mineralcorticoid
Panax ginseng C.A. Mey. Mitogenic
Panax ginseng C.A. Mey. Negative Chronotropic
Panax ginseng C.A. Mey. Negative Inotropic
Panax ginseng C.A. Mey. Nervine
Panax ginseng C.A. Mey. Neurotonic
Panax ginseng C.A. Mey. Nicotinic
Panax ginseng C.A. Mey. NKC-Genic
Panax ginseng C.A. Mey. NO-Genic
Panax ginseng C.A. Mey. Nootropic
Panax ginseng C.A. Mey. Osteoprotective
Panax ginseng C.A. Mey. Phagocytotic
Panax ginseng C.A. Mey. Positive Inotropic
Panax ginseng C.A. Mey. Radioprotective
Panax ginseng C.A. Mey. Respirastimulant
Panax ginseng C.A. Mey. Roborant
Panax ginseng C.A. Mey. Secretagogue
Panax ginseng C.A. Mey. Sedative
Panax ginseng C.A. Mey. Serotonilytic
Panax ginseng C.A. Mey. Sialagogue
Panax ginseng C.A. Mey. Spermatogenic
Panax ginseng C.A. Mey. Stomachic
Panax ginseng C.A. Mey. Testosteronigenic
Panax ginseng C.A. Mey. Thymoleptic
Panax ginseng C.A. Mey. Tonic
Panax ginseng C.A. Mey. Tranquilizer
Panax ginseng C.A. Mey. Ulcerogenic
Panax ginseng C.A. Mey. Vasodilator

Metabolite list (39)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005157 External link 512 Panasenoside
CHEMBL500233
CHEMBL1375795
CHEMBL2032411
12 / 2 / 2 No. 1 No. 15
C00030447 External link 512 Gypenoside XVII
CHEMBL504441
No. 11 No. 51
C00030844 External link 512 Notoginsenoside Fe
No. 11 No. 51
C00030398 External link 512 Ginsenoside Rd
CHEMBL473659
C049863
2 / 0 / 0 0 / 1 No. 11 No. 51
C00031098 External link 512 Pseudoginsenoside F8
No. 11 No. 51
C00003518 External link 512 Ginsenoside Re
CHEMBL510095
C049864
2 / 0 / 0 0 / 1 No. 11 No. 51
C00033154 External link 512 Majoroside F4
No. 32 No. 51
C00003520 External link 512 Ginsenoside Rg1
CHEMBL501637
CHEMBL1977916
C035054
5 / 6 No. 32 No. 51
C00032815 External link 512 Ginsenoside F5
/ Chikusetsusaponin L8
CHEMBL583152
2 / 0 / 0 No. 32 No. 51
C00032990 External link 512 Ginsenoside Rg7
No. 32 No. 51
C00003519 External link 512 Ginsenoside Rf
CHEMBL1773987
C055328
1 / 0 No. 32 No. 51
C00030399 External link 512 Panaxoside Rg2
/ Ginsenoside Rg2
CHEMBL505747
CHEMBL1095005
CHEMBL1095006
CHEMBL1475728
C026474
5 / 0 / 0 7 / 2 No. 32 No. 51
C00033153 External link 512 Majoroside F2
No. 32 No. 51
C00030390 External link 512 Ginsenoside F3
CHEMBL1095004
2 / 0 / 0 No. 32 No. 51
C00030254 External link 512 Floralginsenoside A
No. 32 No. 51
C00030255 External link 512 Floralginsenoside B
No. 32 No. 51
C00030256 External link 512 Floralginsenoside C
/ (+)-Floralginsenoside C
No. 32 No. 51
C00030257 External link 512 Floralginsenoside D
No. 32 No. 51
C00030258 External link 512 Floralginsenoside E
/ (+)-Floralginsenoside E
No. 32 No. 51
C00030389 External link 512 Ginsenoside F2
CHEMBL1095007
2 / 0 / 0 No. 32 No. 51
C00030259 External link 512 Floralginsenoside F
/ (+)-Floralginsenoside F
No. 32 No. 51
C00030388 External link 512 Ginsenoside F1
CHEMBL584011
C055327
No. 99
C00032992 External link 512 Ginsenoside Rh6
/ (+)-Ginsenoside Rh6
No. 99
C00032991 External link 512 Ginsenoside Rh5
CHEMBL454530
No. 99
C00032994 External link 512 Ginsenoside Rh8
/ (+)-Ginsenoside Rh8
No. 99
C00032995 External link 512 Ginsenoside Rh9
No. 99
C00032993 External link 512 Ginsenoside Rh7
/ (+)-Ginsenoside Rh7
No. 99
C00021836 External link 512 Panasinsanol A
C053938
No. 161 No. 38
C00021835 External link 512 Panasinsanol B
C053937
No. 161 No. 38
C00021833 External link 512 beta-Panasinsene
/ beta-Panasinsanene
No. 365 No. 38
C00021834 External link 512 alpha-Panasinsanene
No. 365 No. 38
C00021986 External link 512 beta-Neoclovene
No. 365 No. 38
C00031489 External link 512 1,8-Heptadecadiene-4,6-diyne-3,10-diol
CHEMBL463807
CHEMBL448210
C056818
No. 940 No. 69
C00001284 External link 512 Panaxynol
/ Falcarinol
/ (-)-Falcarinol
CHEMBL71260
CHEMBL368712
C018541
0 / 2 No. 940 No. 69
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
CHEMBL120568
D014641
5 / 3 / 3 5 / 0 No. 1073
C00000100 External link 512 IAA
/ Indole-3-acetic acid
CHEMBL82411
C030737
3 / 0 / 0 2 / 1 No. 1432 No. 4
C00030922 External link 512 Panaxydol
/ (-)-Panaxydol
C055778
6 / 1 No. 3682
C00000101 External link 512 IAA methyl ester
/ Methyl indole-3-acetate
No. 4225
C00001756 External link 512 Perlolyrine
/ Tribulusterine
CHEMBL501991
C055781
No. 5379 No. 4

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11387 DNA topoisomerase 1 Isomerase C00003518 C00030389 C00030390 C00030398 C00030399 C00032815 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003518 C00030389 C00030390 C00030398 C00030399 C00032815 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002682 C00005157 0 / 0
O75496 Geminin Unclassified protein C00005157 C00030399 0 / 0
P15121 Aldose reductase Enzyme C00002682 0 / 0
P06746 DNA polymerase beta Enzyme C00005157 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005157 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005157 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00005157 0 / 0
P42858 Huntingtin Unclassified protein C00002682 1 / 1
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00000100 0 / 0
P02768 Serum albumin Secreted protein C00000100 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005157 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00030399 0 / 0
Q9HBH1 Peptide deformylase, mitochondrial Enzyme C00000100 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00030399 0 / 0
P03372 Estrogen receptor NR3A1 C00002682 1 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00002682 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00005157 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005157 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005157 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005157 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005157 0 / 0

24 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00003519 C00003520
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003520 C00030922
200186 CRTC2, TORC-2, TORC2 CREB regulated transcription coactivator 2 C00030399
8431 NR0B2, SHP, SHP1 nuclear receptor subfamily 0, group B, member 2 C00030399
5105 PCK1, PEPCK-C, PEPCK1, PEPCKC phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32) C00030399
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00030399
6794 STK11, LKB1, PJS, hLKB1 serine/threonine kinase 11 (EC:2.7.11.1) C00030399
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000100
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000100
898 CCNE1, CCNE cyclin E1 C00003520
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00003520
92579 G6PC3, SCN4, UGRP glucose 6 phosphatase, catalytic, 3 (EC:3.1.3.9) C00030399
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00030399
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00003520
174 AFP, FETA, HPAFP alpha-fetoprotein C00030922
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00030922
3397 ID1, ID, bHLHb24 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein C00030922
3398 ID2, GIG8, ID2A, ID2H, bHLHb26 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein C00030922
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00030922
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002682
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002682
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002682
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002682
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002682

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#615363 Estrogen resistance; estrr P03372
#232300 Glycogen storage disease ii P10253
#143100 Huntington disease; hd P42858
#610460 Thiopurine s-methyltransferase deficiency P51580
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (5)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

12 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006948 Hyperkinesis C00030399
C00003520
C00003518
D003928 Diabetic Nephropathies C00003520
D019970 Cocaine-Related Disorders C00030399
D002545 Brain Ischemia C00001284
D056486 Drug-Induced Liver Injury C00000100
D003704 Dementia C00003520
D015427 Reperfusion Injury C00001284
D007249 Inflammation C00003520
D007859 Learning Disorders C00003520
D008569 Memory Disorders C00003520
D007674 Kidney Diseases C00030398
D006528 Carcinoma, Hepatocellular C00030922