Lycoris radiata
Species
KNApSAcK Entry
| Organism name | Lycoris radiata |
|---|---|
| Genus | Lycoris |
| Family | Amaryllidaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Lycoris radiata |
|---|---|
| Linked NCBI taxonomy ID | 228395 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Amaryllidaceae |
|---|---|
| ID | 4668 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001580
|
Pretazettine
|
CHEMBL606758
CHEMBL2010422 |
C010766
|
No. 103 | No. 4 |
|
||
|
C00000952
|
7,3'-Dihydroxy-4'-methoxy-8-methylflavan
|
No. 179 | No. 15 |
|
||||
|
C00001572
|
Hippeastrine
|
CHEMBL457606
CHEMBL1333401 CHEMBL1515264 |
C060577
|
8 / 3 / 4 | No. 715 |
|
||
|
C00001576
|
Lycorine
/ (-)-Lycorine |
CHEMBL224745
CHEMBL400092 CHEMBL583716 CHEMBL577635 CHEMBL1592744 CHEMBL1593638 |
C015330
|
20 / 24 / 18 | 5 / 5 | No. 1156 | No. 4 |
|
|
C00001574
|
Lycorenine
|
CHEMBL1885951
|
C023825
|
2 / 0 / 0 | No. 2353 |
|
||
|
C00001577
|
Narciclasine
/ Lycoricidinol |
CHEMBL98745
CHEMBL367376 |
C010753
|
9 / 17 / 9 | No. 4581 |
|
||
|
C00001575
|
Lycoricidine
|
CHEMBL487798
CHEMBL1728514 |
9 / 6 / 4 | No. 4581 |
|
Human Protein / Gene in interactions
33 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q99700 | Ataxin-2 | Unclassified protein | C00001572 C00001575 C00001576 C00001577 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001572 C00001576 C00001577 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00001574 C00001575 C00001577 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001575 C00001577 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001572 C00001576 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001576 C00001577 | 2 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001572 C00001576 | 0 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001575 C00001577 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001572 C00001576 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001572 C00001576 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001572 C00001576 | 1 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001577 | 7 / 3 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001576 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001575 | 2 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001572 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001575 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001577 | 2 / 2 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001575 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001574 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001576 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001576 | 2 / 3 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001576 | 1 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001576 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00001576 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001576 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001575 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00001577 | 4 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001576 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001576 | 11 / 10 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001576 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001576 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001576 | 4 / 1 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00001575 | 1 / 2 |
5 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 896 | CCND3 | cyclin D3 |
C00001576
|
| 1003 | CDH5, 7B4, CD144 | cadherin 5, type 2 (vascular endothelium) |
C00001576
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001576
|
| 10507 | SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
C00001576
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00001576
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (42)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (28)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00032 | Thyroid cancer |
Q06710
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
Q06710
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|