Species

KNApSAcK Entry

Organism name Macaranga conifera
Genus Macaranga
Family Euphorbiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Macaranga conifera
Linked NCBI taxonomy ID 109817
Linked level species

Family

Family in NCBI taxonomy Euphorbiaceae
ID 3977

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029441 External link 512 20-Epibryonolic acid
CHEMBL482596
CHEMBL1982562
No. 13 No. 51
C00005010 External link 512 Isolicoflavonol
/ 3,5,7-Trihydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]-4H-1-benzopyran-4-one
CHEMBL457679
5 / 5 / 3 No. 15 No. 15
C00000954 External link 512 Senegalensein
/ Lonchocarpol A
/ 6,8-Diprenylnaringenin
CHEMBL477969
CHEMBL1545584
C068505
16 / 26 / 18 No. 19 No. 14
C00014198 External link 512 Tomentosanol D
/ 5,7,4'-Trihydroxy-8-(2-hydroxy-3-methylbutyl-3-enyl)flavanone
CHEMBL443717
No. 28 No. 14
C00008245 External link 512 8-Prenylnaringenin
/ Sophoraflavanone B
/ (-)-8-Prenylnaringenin
CHEMBL376915
CHEMBL460647
10 / 8 / 4 No. 28 No. 14
C00008621 External link 512 Lupinifolinol
CHEMBL559586
No. 39
C00014231 External link 512 5-Hydroxy-4'-methoxy-6'',6''-dimethylpyrano[2'',3'':7,8]flavanone
No. 127 No. 14
C00014212 External link 512 Phellodensin D
/ 5,4'-Dihydroxy-2''-(1-hydroxy-1-methylethyl)dihydrofuro[2,3-h]flavanone
No. 740

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00000954 C00005010 C00008245 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000954 C00008245 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000954 C00008245 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000954 C00005010 2 / 0
Q9Y253 DNA polymerase eta Enzyme C00005010 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008245 0 / 0
P37840 Alpha-synuclein Unclassified protein C00008245 4 / 2
P39748 Flap endonuclease 1 Enzyme C00000954 0 / 0
P06746 DNA polymerase beta Enzyme C00000954 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000954 1 / 1
Q92731 Estrogen receptor beta NR3A2 C00008245 0 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000954 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000954 7 / 3
P04062 Glucosylceramidase Enzyme C00000954 6 / 4
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00005010 2 / 2
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00008245 2 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00008245 0 / 0
P03372 Estrogen receptor NR3A1 C00008245 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005010 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000954 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000954 4 / 3
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000954 1 / 0
O00255 Menin Unclassified protein C00000954 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000954 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00008245 0 / 0
P17861 X-box-binding protein 1 Unclassified protein C00000954 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614490 Blood group, junior system; jr Q9UNQ0
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (23)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)