PCIDB

Cupressus sempervirens

Species

KNApSAcK Entry

Organism name Cupressus sempervirens
Genus Cupressus
Family Cupressaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cupressus sempervirens
Linked NCBI taxonomy ID 13469
Linked level species

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Natural Activity

List (11)

Species Activity
Cupressus sempervirens L. Anthelminthic
Cupressus sempervirens L. Antiseptic
Cupressus sempervirens L. Astringent
Cupressus sempervirens L. Diaphoretic
Cupressus sempervirens L. Diuretic
Cupressus sempervirens L. Expectorant
Cupressus sempervirens L. Hemostat
Cupressus sempervirens L. Insectifuge
Cupressus sempervirens L. Pectoral
Cupressus sempervirens L. Stimulant
Cupressus sempervirens L. Vasoconstrictor

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00005440 External link 512 Quercetin 3-O-alpha-L-rhamnopyranoside
No. 5 No. 15
C00001034 External link 512 Cupressuflavone
CHEMBL1208973
6 / 1 / 1 No. 34 No. 18
C00001049 External link 512 Hinokiflavone
CHEMBL291426
C060299
2 / 1 / 2 No. 34 No. 18
C00006535 External link 512 Isocryptomerin
No. 34 No. 18
C00022721 External link 512 Torulosic acid
/ Cupressic acid
/ 13R-Hydroxy-8(17),14-labdadien-19-oic acid
CHEMBL457163
No. 143
C00036233 External link 512 trans-Communic acid
CHEMBL498097
CHEMBL1488779
CHEMBL1731589
13 / 14 / 8 No. 143
C00003112 External link 512 Cedrol
/ (+)-Cedrol
/ alpha-Cedrol
CHEMBL1592444
CHEMBL1974890
C078669
5 / 14 / 11 No. 161 No. 38
C00034999 External link 512 1R-alpha-Pinene
/ (+)-(1R)-alpha-Pinene
/ 1R,5R-(+)-alpha-Pinene
CHEMBL442565
3 / 3 / 2 No. 476 No. 35

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9Y253 DNA polymerase eta Enzyme C00001034 C00005374 C00036233 1 / 1
P39748 Flap endonuclease 1 Enzyme C00001034 C00005374 C00036233 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001034 C00005374 C00036233 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001034 C00005374 C00036233 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005374 C00036233 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005374 C00036233 0 / 0
P56817 Beta-secretase 1 A1A C00001034 C00001049 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00003112 C00034999 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005374 C00036233 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003112 C00005374 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
O75496 Geminin Unclassified protein C00001034 0 / 0
P15121 Aldose reductase Enzyme C00005374 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00036233 7 / 3
P43235 Cathepsin K C1A C00001049 1 / 2
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003112 3 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00034999 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00036233 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003112 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005374 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00034999 3 / 2
P02545 Prelamin-A/C Unclassified protein C00003112 11 / 10
P10636 Microtubule-associated protein tau Unclassified protein C00036233 4 / 3
P06746 DNA polymerase beta Enzyme C00036233 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005374 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00036233 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00036233 2 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#265800 Pycnodysostosis P43235
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (24)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D010146 Pain C00005374