Species

KNApSAcK Entry

Organism name Robinsonecio gerberifolius
Genus Robinsonecio
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Robinsonecio gerberifolius
Linked NCBI taxonomy ID 98718
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00023770 External link 512 Sitosterol
/ Stigmasta-5,22-dien-3beta-ol
/ (24R)24-Ethylcholesta-5,22-dien-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00002698 External link 512 Piceol
/ p-Hydroxyacetophenone
/ 4'-Hydroxyacetophenone
CHEMBL201083
C031335
5 / 3 / 3 No. 2849
C00001151 External link 512 Sucrose
/ (+)-Sucrose
CHEMBL253582
CHEMBL1976550
D013395
1 / 0 / 0 4 / 10 No. 3949

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00019308 C00023770 C00023774 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019308 C00023770 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019308 C00023770 0 / 0
P00734 Prothrombin S1A C00019308 C00023770 4 / 2
P08047 Transcription factor Sp1 Unclassified protein C00019308 C00023770 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00023770 1 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002698 1 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P02768 Serum albumin Secreted protein C00001151 0 / 0
P08183 Multidrug resistance protein 1 drug C00023770 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00023770 0 / 1
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002698 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00023770 2 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00023770 3 / 2
P14679 Tyrosinase Oxidoreductase C00023770 4 / 2
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002698 1 / 1
P37058 Testosterone 17-beta-dehydrogenase 3 Enzyme C00002698 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00023770 0 / 0
P03372 Estrogen receptor NR3A1 C00023770 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00023770 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00023770 0 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002698 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00023770 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00023770 1 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001151
55630 SLC39A4, AEZ, AWMS2, ZIP4 solute carrier family 39 (zinc transporter), member 4 C00001151
80834 TAS1R2, GPR71, T1R2, TR2 taste receptor, type 1, member 2 C00001151
83756 TAS1R3, T1R3 taste receptor, type 1, member 3 C00001151

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#264300 17-beta hydroxysteroid dehydrogenase iii deficiency P37058
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613163 Gaba-transaminase deficiency P80404
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (15)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P37058 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

13 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308
D019969 Amphetamine-Related Disorders C00001151
D018149 Glucose Intolerance C00001151
D006461 Hemolysis C00001151
D006946 Hyperinsulinism C00001151
D006948 Hyperkinesis C00001151
D006973 Hypertension C00001151
D007333 Insulin Resistance C00001151
D009401 Nephrosis C00001151
C541083 Non-alcoholic Fatty Liver Disease C00001151
D019966 Substance-Related Disorders C00001151