Nicotiana mutabilis
Species
KNApSAcK Entry
| Organism name | Nicotiana mutabilis |
|---|---|
| Genus | Nicotiana |
| Family | Solanaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Nicotiana mutabilis |
|---|---|
| Linked NCBI taxonomy ID | 497760 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Solanaceae |
|---|---|
| ID | 4070 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (10)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000816
|
beta-Pinene
|
CHEMBL501351
|
C010789
|
No. 476 | No. 35 |
|
||
|
C00000805
|
alpha-Pinene
|
CHEMBL442565
|
C005451
|
3 / 3 / 2 | 0 / 1 | No. 476 | No. 35 |
|
|
C00003110
|
Caryophyllene
/ (E)-Caryophyllene / beta-Caryophyllene / (-)-(E)-Caryophyllene / (E)-beta-Caryophyllene |
CHEMBL445740
CHEMBL448700 |
2 / 3 / 7 | No. 478 | No. 38 |
|
||
|
C00003047
|
Linalool
/ (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol |
CHEMBL25306
CHEMBL235672 |
C018584
|
6 / 8 / 2 | 35 / 4 | No. 958 | No. 34 |
|
|
C00029674
|
alpha-Terpineol
|
CHEMBL447597
CHEMBL449810 |
C016775
|
3 / 16 / 11 | No. 983 | No. 35 |
|
|
|
C00031258
|
Sabinene
/ 4(10)-Thujene |
CHEMBL452687
|
C035127
|
No. 1343 | No. 35 |
|
||
|
C00029335
|
beta-Ocimene
/ E-beta-Ocimene / (E)-beta-Ocimene |
C443996
|
No. 1698 | No. 34 |
|
|||
|
C00030767
|
Methyl salicylate
|
CHEMBL108545
|
C033069
|
92 / 52 / 46 | 29 / 3 | No. 2169 |
|
|
|
C00000853
|
Myrcene
|
CHEMBL455491
|
C008574
|
3 / 3 / 3 | No. 2285 | No. 34 |
|
|
|
C00000136
|
1,8-Cineole
|
CHEMBL485259
CHEMBL1397305 |
99 / 57 / 50 | No. 5413 | No. 35 |
|
Human Protein / Gene in interactions
109 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000136 C00000805 C00000853 C00030767 | 3 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000136 C00000853 C00030767 | 0 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000136 C00000805 C00030767 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000136 C00029674 C00030767 | 11 / 10 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000136 C00030767 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000136 C00030767 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00000136 C00030767 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000136 C00030767 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000136 C00030767 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000136 C00030767 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000136 C00030767 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000136 C00030767 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000136 C00030767 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000136 C00030767 | 2 / 2 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000136 C00030767 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000136 C00030767 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000136 C00030767 | 0 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000136 C00030767 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000136 C00030767 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000136 C00030767 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000136 C00030767 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000136 C00030767 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000136 C00030767 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000136 C00030767 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000136 C00030767 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000136 C00030767 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000136 C00030767 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000136 C00030767 | 1 / 8 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000136 C00030767 | 1 / 1 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000136 C00030767 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000136 C00030767 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000136 C00030767 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000136 C00030767 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000136 C00030767 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000136 C00030767 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000136 C00030767 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000136 C00030767 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000136 C00030767 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000136 C00030767 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000136 C00030767 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000136 C00030767 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000136 C00030767 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000136 C00030767 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000136 C00030767 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000136 C00030767 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000136 C00030767 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000136 C00030767 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000136 C00030767 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000136 C00030767 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000136 C00030767 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000136 C00030767 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000136 C00030767 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000136 C00030767 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000136 C00030767 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000136 C00030767 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000136 C00003047 | 0 / 0 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000136 C00030767 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000136 C00030767 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000136 C00030767 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000136 C00030767 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000136 C00030767 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000136 C00030767 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000136 C00030767 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000136 C00030767 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000136 C00030767 | 0 / 3 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000136 C00030767 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000136 C00030767 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000136 C00030767 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000136 C00030767 | 1 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003047 C00029674 | 3 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000136 C00030767 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000136 C00030767 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000136 C00030767 | 1 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003047 C00029674 | 5 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000136 C00030767 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000136 C00030767 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00000136 C00030767 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000136 C00030767 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000136 C00030767 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000136 C00030767 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000136 C00030767 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000136 C00030767 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000136 C00030767 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000136 C00030767 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000136 C00030767 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000136 C00030767 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000136 C00030767 | 0 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000136 C00030767 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003047 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00003047 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000805 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000136 | 4 / 3 |
| P10275 | Androgen receptor | NR3C4 | C00000136 | 3 / 4 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00000136 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00000136 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00000853 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000136 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00030767 | 2 / 3 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003047 | 3 / 1 |
| Q7Z2W7 | Transient receptor potential cation channel subfamily M member 8 | Unclassified protein | C00000136 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000136 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00003110 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003110 | 1 / 2 |
62 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00003047
C00030767
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003047
C00030767
|
| 2730 | GCLM, GLCLR | glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) |
C00030767
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003047
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00003047
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003047
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00003047
|
| 1028 | CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
C00003047
|
| 1030 | CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
C00003047
|
| 1447 | CSN2, CASB | casein beta |
C00003047
|
| 1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00003047
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003047
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00003047
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003047
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00003047
|
| 1647 | GADD45A, DDIT1, GADD45 | growth arrest and DNA-damage-inducible, alpha |
C00003047
|
| 1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00003047
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003047
|
| 3297 | HSF1, HSTF1 | heat shock transcription factor 1 |
C00003047
|
| 3320 | HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
C00003047
|
| 3308 | HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY | heat shock 70kDa protein 4 |
C00003047
|
| 3316 | HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP | heat shock 27kDa protein 2 |
C00003047
|
| 3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00003047
|
| 3638 | INSIG1, CL-6, CL6 | insulin induced gene 1 |
C00003047
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003047
|
| 8850 | KAT2B, CAF, P, P/CAF, PCAF | K(lysine) acetyltransferase 2B (EC:2.3.1.48) |
C00003047
|
| 4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00003047
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003047
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003047
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00003047
|
| 100124292 |
C00003047
|
||
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003047
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00003047
|
| 7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00003047
|
| 26118 | WSB1, SWIP1, WSB-1 | WD repeat and SOCS box containing 1 |
C00003047
|
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00030767
|
| 57016 | AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI | aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) |
C00030767
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00030767
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00030767
|
| 1385 | CREB1, CREB | cAMP responsive element binding protein 1 |
C00030767
|
| 2010 | EMD, EDMD, LEMD5, STA | emerin |
C00030767
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00030767
|
| 2235 | FECH, EPP, FCE | ferrochelatase (EC:4.99.1.1) |
C00030767
|
| 2512 | FTL, NBIA3 | ferritin, light polypeptide |
C00030767
|
| 2539 | G6PD, G6PD1 | glucose-6-phosphate dehydrogenase (EC:1.1.1.49) |
C00030767
|
| 9514 | GAL3ST1, CST | galactose-3-O-sulfotransferase 1 (EC:2.8.2.11) |
C00030767
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00003047
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00030767
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00030767
|
| 4097 | MAFG, hMAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G |
C00030767
|
| 4199 | ME1, HUMNDME, MES | malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) |
C00030767
|
| 4883 | NPR3, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) |
C00030767
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00030767
|
| 5226 | PGD, 6PGD | phosphogluconate dehydrogenase (EC:1.1.1.44) |
C00030767
|
| 22949 | PTGR1, LTB4DH, PGR1, ZADH3 | prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) |
C00030767
|
| 140809 | SRXN1, C20orf139, Npn3, SRX, SRX1 | sulfiredoxin 1 (EC:1.8.98.2) |
C00030767
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00030767
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00030767
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00030767
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00030767
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00030767
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00030767
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (70)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (62)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
8 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003877 | Dermatitis, Contact |
C00000805
|
| D017453 | Dermatitis, Irritant |
C00003047
|
| D006937 | Hypercholesterolemia |
C00003047
|
| D007938 | Leukemia |
C00003047
|
| D009369 | Neoplasms |
C00003047
|
| D009135 | Muscular Diseases |
C00030767
|
| D009336 | Necrosis |
C00030767
|
| D009395 | Nephritis, Interstitial |
C00030767
|