PCIDB

Aristolochia indica

Species

KNApSAcK Entry

Organism name Aristolochia indica
Genus Aristolochia
Family Aristolochiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aristolochia indica
Linked NCBI taxonomy ID 158548
Linked level species

Family

Family in NCBI taxonomy Aristolochiaceae
ID 16727

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00016976 External link 512 Aristolochen
/ Aristolochene
/ (-)-Aristolochene
CHEMBL484228
C054277
No. 151 No. 38
C00012716 External link 512 5beta,10alpha-Eudesma-4(14),11-diene
/ [4aS-(4aalpha,7beta,8abeta)]-Decahydro-4a-methyl-1-methylene-7-(1-methylethenyl)naphthalene
No. 151 No. 38
C00021876 External link 512 7,12-Seco-12-ishwaranol
CHEMBL521019
No. 161 No. 38
C00001526 External link 512 Aristolochic acid I
/ Aristolochic acid A
CHEMBL93353
C000228
13 / 11 / 12 21 / 10 No. 291 No. 4
C00002608 External link 512 Hinokinin
/ Hinoquinin
/ (-)-Hinokinin
/ (-)-Hinoquinin
CHEMBL180970
CHEMBL182073
CHEMBL242011
C475934
2 / 1 / 1 No. 629 No. 21
C00002794 External link 512 Aristolindiquinone
No. 1119 No. 80
C00021873 External link 512 Ishwarone
No. 2284
C00021872 External link 512 Ishwarol
No. 2284
C00021871 External link 512 Ishwarane
No. 2284
C00021875 External link 512 Isoishwarone
/ endo-Isoishwarone
No. 3131

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001526 C00002608 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002608 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001526 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001526 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001526 0 / 0
O75496 Geminin Unclassified protein C00001526 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001526 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001526 4 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001526 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001526 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00001526 0 / 0
O00255 Menin Unclassified protein C00001526 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001526 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001526 0 / 0

21 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00001526
655 BMP7, OP-1 bone morphogenetic protein 7 C00001526
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001526
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00001526
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001526
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001526
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00001526
1965 EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa C00001526
2034 EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 endothelial PAS domain protein 1 C00001526
26585 GREM1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2 gremlin 1, DAN family BMP antagonist C00001526
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00001526
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001526
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001526
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00001526
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00001526
9376 SLC22A8, OAT3 solute carrier family 22 (organic anion transporter), member 8 C00001526
4086 SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 SMAD family member 1 C00001526
4090 SMAD5, DWFC, JV5-1, MADH5 SMAD family member 5 C00001526
4093 SMAD9, MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B SMAD family member 9 C00001526
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00001526
7494 XBP1, TREB5, XBP-1, XBP2 X-box binding protein 1 C00001526

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (12)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001284 Atrophy C00001526
D001449 Balkan Nephropathy C00001526
D018376 Cardiovascular Abnormalities C00001526
D007249 Inflammation C00001526
D007674 Kidney Diseases C00001526
D007680 Kidney Neoplasms C00001526
D007683 Kidney Tubular Necrosis, Acute C00001526
D009369 Neoplasms C00001526
D051437 Renal Insufficiency C00001526
D014571 Urologic Neoplasms C00001526