Aristolochia ponticum
Species
KNApSAcK Entry
| Organism name | Aristolochia ponticum |
|---|---|
| Genus | Aristolochia |
| Family | Aristolochiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Aristolochia |
|---|---|
| Linked NCBI taxonomy ID | 12947 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Aristolochiaceae |
|---|---|
| ID | 16727 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00021674
|
Nectandrin B
/ Malabaricanol |
CHEMBL228326
CHEMBL1170325 |
1 / 0 / 1 | No. 38 | No. 21 |
|
||
|
C00021676
|
9-Methoxyaristolactam I
/ 9-Methoxyaristololactam I |
No. 125 |
|
|||||
|
C00021673
|
Aristololactam III
|
No. 125 |
|
|||||
|
C00027515
|
Aristolactam
/ Aristolactam I |
CHEMBL479127
|
C121135
|
1 / 0 / 0 | No. 125 |
|
||
|
C00021675
|
7-Methoxyaristolochic acid II
|
No. 291 | No. 4 |
|
||||
|
C00021671
|
Aristolochic acid B
/ Aristolochic acid II |
CHEMBL602280
|
C042310
|
1 / 0 / 0 | No. 291 | No. 4 |
|
|
|
C00001526
|
Aristolochic acid I
/ Aristolochic acid A |
CHEMBL93353
|
C000228
|
13 / 11 / 12 | 21 / 10 | No. 291 | No. 4 |
|
Human Protein / Gene in interactions
14 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001526 C00021671 C00027515 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001526 | 0 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001526 | 4 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001526 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001526 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001526 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00021674 | 0 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001526 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001526 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001526 | 0 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00001526 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001526 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001526 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001526 | 0 / 0 |
21 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 59 | ACTA2, AAT6, ACTSA, MYMY5 | actin, alpha 2, smooth muscle, aorta |
C00001526
|
| 655 | BMP7, OP-1 | bone morphogenetic protein 7 |
C00001526
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001526
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00001526
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001526
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001526
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00001526
|
| 1965 | EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
C00001526
|
| 2034 | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 | endothelial PAS domain protein 1 |
C00001526
|
| 26585 | GREM1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2 | gremlin 1, DAN family BMP antagonist |
C00001526
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00001526
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001526
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001526
|
| 55867 | SLC22A11, OAT4, hOAT4 | solute carrier family 22 (organic anion/urate transporter), member 11 |
C00001526
|
| 9356 | SLC22A6, HOAT1, OAT1, PAHT, ROAT1 | solute carrier family 22 (organic anion transporter), member 6 |
C00001526
|
| 9376 | SLC22A8, OAT3 | solute carrier family 22 (organic anion transporter), member 8 |
C00001526
|
| 4086 | SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 | SMAD family member 1 |
C00001526
|
| 4090 | SMAD5, DWFC, JV5-1, MADH5 | SMAD family member 5 |
C00001526
|
| 4093 | SMAD9, MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B | SMAD family member 9 |
C00001526
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00001526
|
| 7494 | XBP1, TREB5, XBP-1, XBP2 | X-box binding protein 1 |
C00001526
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (11)
| OMIM | preferred title | UniProt |
|---|---|---|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001284 | Atrophy |
C00001526
|
| D001449 | Balkan Nephropathy |
C00001526
|
| D018376 | Cardiovascular Abnormalities |
C00001526
|
| D007249 | Inflammation |
C00001526
|
| D007674 | Kidney Diseases |
C00001526
|
| D007680 | Kidney Neoplasms |
C00001526
|
| D007683 | Kidney Tubular Necrosis, Acute |
C00001526
|
| D009369 | Neoplasms |
C00001526
|
| D051437 | Renal Insufficiency |
C00001526
|
| D014571 | Urologic Neoplasms |
C00001526
|