| Organism name | Centaurea sessilis |
|---|---|
| Genus | Centaurea |
| Family | Asteraceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Centaurea |
|---|---|
| Linked NCBI taxonomy ID | 41503 |
| Linked level | genus |
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | asterids |
|---|---|
| ID | 71274 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00035896
|
Vulgarol B
|
No. 149 | No. 38 |
|
||||
|
C00021423
|
1,5-Epoxysalvial-4(14)-ene
|
No. 311 |
|
|||||
|
C00003118
|
Copaene
/ alpha-Copaene / (-)-alpha-Copaene |
No. 333 | No. 38 |
|
||||
|
C00029977
|
cis-Verbenol
|
No. 476 | No. 35 |
|
||||
|
C00000816
|
beta-Pinene
|
CHEMBL501351
|
C010789
|
No. 476 | No. 35 |
|
||
|
C00003110
|
Caryophyllene
/ (E)-Caryophyllene / beta-Caryophyllene / (-)-(E)-Caryophyllene / (E)-beta-Caryophyllene |
CHEMBL445740
CHEMBL448700 |
2 / 3 / 7 | No. 478 | No. 38 |
|
||
|
C00000164
|
beta-Eudesmol
|
CHEMBL88244
|
C051082
|
No. 524 | No. 38 |
|
||
|
C00035560
|
Cetene
|
C010734
|
No. 599 |
|
||||
|
C00030480
|
Hexahydrofarnesyl acetone
/ 6,10,14-Trimethyl-2-pentadecanone |
C014584
|
No. 641 | No. 38 |
|
|||
|
C00022119
|
(Z)-Phytol
/ cis-Phytol |
CHEMBL390773
CHEMBL1644111 |
No. 641 | No. 38 |
|
|||
|
C00007242
|
beta-Bisabolene
/ l-beta-Bisabolene / (-)-beta-Bisabolene |
CHEMBL444389
CHEMBL1077088 CHEMBL2001434 |
No. 701 | No. 38 |
|
|||
|
C00000823
|
Limonene
|
CHEMBL15799
CHEMBL449062 |
C008281
|
7 / 21 / 48 | 6 / 6 | No. 848 | No. 35 |
|
|
C00007535
|
Phenylacetaldehyde
/ Benzeneacetaldehyde / Phenylacetic aldehyde |
C013192
|
3 / 0 | No. 885 |
|
|||
|
C00003047
|
Linalool
/ (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol |
CHEMBL25306
CHEMBL235672 |
C018584
|
6 / 8 / 2 | 35 / 4 | No. 958 | No. 34 |
|
|
C00029881
|
Calarene
/ (+)-1(10)-Aristolene |
No. 1097 |
|
|||||
|
C00021283
|
Cyperene
|
No. 1454 |
|
|||||
|
C00022163
|
Farnesylacetone
/ Farnesyl acetone |
CHEMBL486207
|
No. 1468 |
|
||||
|
C00000149
|
Spathulenol
|
CHEMBL518542
CHEMBL1774433 |
C013258
|
No. 1603 |
|
|||
|
C00020067
|
alpha-Calacorene
|
No. 1859 |
|
|||||
|
C00030804
|
n-Decanal
|
C021170
|
2 / 0 | No. 1993 |
|
|||
|
C00030828
|
Nonanal
/ n-Nonanal |
C008664
|
1 / 1 | No. 1993 |
|
|||
|
C00003040
|
p-Cymene
|
CHEMBL442915
|
C007210
|
No. 2172 | No. 35 |
|
||
|
C00029816
|
beta-Ionone
|
CHEMBL559945
|
No. 2480 | No. 38 |
|
|||
|
C00011720
|
Germacrene D
/ (-)-Germacrene D |
CHEMBL105432
CHEMBL1836650 |
No. 2639 | No. 38 |
|
|||
|
C00034763
|
2-Amylfuran
/ 2-Pentylfuran |
No. 3145 |
|
|||||
|
C00034880
|
n-Heptanal
|
CHEMBL18104
|
C046204
|
2 / 3 / 2 | 1 / 0 | No. 3593 |
|
|
|
C00030880
|
Octanal
/ n-Octanal |
CHEMBL18407
|
C031639
|
2 / 0 | No. 3593 |
|
||
|
C00021428
|
Mintketone
/ Salvial-4(14)-en-1-one |
No. 3830 |
|
|||||
|
C00000827
|
(+)-Pulegone
/ (+)-(R)-Pulegone |
CHEMBL366136
CHEMBL1898498 |
2 / 0 / 0 | No. 4648 | No. 35 |
|
||
|
C00034452
|
Benzaldehyde
|
CHEMBL15972
|
C032175
|
8 / 7 / 3 | 3 / 1 | No. 6311 |
|
|
|
C00035894
|
Verbenene
|
No. 6596 |
|
|||||
|
C00035509
|
5-Pentyl-3H-furan-2-one
/ 5-(1-Pentyl)-3H-furan-2-one |
No. 6669 |
|
|||||
|
C00035737
|
Safranal
|
C087963
|
No. 7781 |
|
||||
|
C00035586
|
Dihydroedulan I
|
No. 7983 |
|
|||||
|
C00035536
|
beta-Damascenone
|
No. 8050 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000823 C00000827 C00034452 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000823 C00003047 | 3 / 1 |
| P10145 | Interleukin-8 | Secreted protein | C00034452 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003047 | 3 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000823 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00034880 | 3 / 2 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000823 | 7 / 37 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000823 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00034452 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00034452 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00034452 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00034452 | 2 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000823 | 0 / 3 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00034880 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003047 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00034452 | 4 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00000827 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00003047 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00034452 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003047 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003047 | 5 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000823 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00003110 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003110 | 1 / 2 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00030804
C00030828
C00030880
C00034880
|
| 1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00003047
C00007535
|
| 217 | ALDH2, ALDH-E2, ALDHI, ALDM | aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) |
C00030804
C00034452
|
| 221 | ALDH3B1, ALDH4, ALDH7 | aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) |
C00030880
C00034452
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00000823
C00003047
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000823
C00003047
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000823
C00003047
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00003047
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00007535
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00007535
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003047
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00003047
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003047
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00003047
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003047
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00003047
|
| 1028 | CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
C00003047
|
| 1030 | CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
C00003047
|
| 1447 | CSN2, CASB | casein beta |
C00003047
|
| 1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00003047
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00003047
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003047
|
| 3265 | HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 | Harvey rat sarcoma viral oncogene homolog |
C00000823
|
| 1647 | GADD45A, DDIT1, GADD45 | growth arrest and DNA-damage-inducible, alpha |
C00003047
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00003047
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003047
|
| 3297 | HSF1, HSTF1 | heat shock transcription factor 1 |
C00003047
|
| 3320 | HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
C00003047
|
| 3308 | HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY | heat shock 70kDa protein 4 |
C00003047
|
| 3316 | HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP | heat shock 27kDa protein 2 |
C00003047
|
| 3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00003047
|
| 3638 | INSIG1, CL-6, CL6 | insulin induced gene 1 |
C00003047
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003047
|
| 8850 | KAT2B, CAF, P, P/CAF, PCAF | K(lysine) acetyltransferase 2B (EC:2.3.1.48) |
C00003047
|
| 4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00003047
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003047
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003047
|
| 100124292 |
C00003047
|
||
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00003047
|
| 7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00003047
|
| 26118 | WSB1, SWIP1, WSB-1 | WD repeat and SOCS box containing 1 |
C00003047
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000823
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000823
|
| 218 | ALDH3A1, ALDH3, ALDHIII | aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5) |
C00034452
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003877 | Dermatitis, Contact |
C00000823
|
| D007674 | Kidney Diseases |
C00000823
|
| D008107 | Liver Diseases |
C00000823
|
| D008114 | Liver Neoplasms, Experimental |
C00000823
|
| D008569 | Memory Disorders |
C00000823
|
| D013276 | Stomach Ulcer |
C00000823
|
| D009336 | Necrosis |
C00030828
|
| D017453 | Dermatitis, Irritant |
C00003047
|
| D006937 | Hypercholesterolemia |
C00003047
|
| D007938 | Leukemia |
C00003047
|
| D009369 | Neoplasms |
C00003047
|
| D012640 | Seizures |
C00034452
|