Species

KNApSAcK Entry

Organism name Vinca erecta Rgl.et Schmalh.
Genus Vinca
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Vinca
Linked NCBI taxonomy ID 60092
Linked level genus

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025183 External link 512 Isoreserpiline
/ Neoreserpiline
CHEMBL1622689
No. 246 No. 4
C00025202 External link 512 Ervine
/ Rauniticine
CHEMBL122404
CHEMBL123325
CHEMBL498734
CHEMBL486933
CHEMBL1604074
CHEMBL2079609
32 / 28 / 31 No. 246 No. 4
C00002198 External link 512 Skimmianine
CHEMBL21396
C035932
18 / 32 / 62 No. 368 No. 7
C00001782 External link 512 Vincamine
CHEMBL1165342
CHEMBL1361052
CHEMBL1592905
CHEMBL1604925
CHEMBL1728279
D014749
27 / 24 / 25 0 / 1 No. 452 No. 4
C00025193 External link 512 Tombozin
/ Tombozine
/ Vellosiminol
/ Normacusine B
/ 10-Deoxysarpagine
CHEMBL477697
No. 490 No. 4
C00001688 External link 512 Apovincamine
CHEMBL1163488
C063621
No. 502 No. 4
C00001713 External link 512 Eburnamine
/ (-)-Eburnamine
CHEMBL2104946
No. 502 No. 4
C00024543 External link 512 Kopsanone
/ 22-Oxokopsan
/ Kopsan-22-one
No. 571
C00024558 External link 512 Kopsinilam
/ (-)-Kopsinilam
No. 571
C00024454 External link 512 Kopsinine
/ (-)-Kopsinine
CHEMBL93355
CHEMBL253984
C061491
No. 571
C00001682 External link 512 Akuammine
CHEMBL484665
C074723
No. 946
C00025196 External link 512 Picrinine
/ Deacetyldeformopicraline
CHEMBL590510
2 / 2 / 2 No. 946
C00001680 External link 512 (-)-Akuammicine:Akuammicine
CHEMBL508955
No. 1800 No. 4
C00025960 External link 512 Norfluorocurarine
/ C-Norcurarine III
/ nor-C-Fluorocurarine
/ (-)-Norfluorocurarine
CHEMBL1395099
5 / 6 / 11 No. 1800 No. 4
C00026077 External link 512 Vincanidine
No. 1800 No. 4

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001782 C00002198 C00025202 C00025960 1 / 2
O00255 Menin Unclassified protein C00001782 C00002198 C00025202 C00025960 2 / 5
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001782 C00002198 C00025202 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001782 C00002198 C00025202 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001782 C00002198 C00025202 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001782 C00002198 C00025202 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001782 C00002198 C00025202 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001782 C00002198 C00025202 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001782 C00002198 C00025202 1 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001782 C00002198 C00025202 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025202 C00025960 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002198 C00025202 11 / 10
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001782 C00025202 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001782 C00025960 2 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001782 C00025202 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025202 C00025960 1 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00001782 C00025202 2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001782 C00025202 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001782 C00025202 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001782 C00002198 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002198 C00025202 3 / 3
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00001782 C00025202 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001782 C00025202 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001782 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001782 7 / 3
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00025202 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00025202 0 / 0
O75496 Geminin Unclassified protein C00002198 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002198 2 / 2
P42858 Huntingtin Unclassified protein C00025202 1 / 1
P55210 Caspase-7 C14 C00025202 0 / 0
P68871 Hemoglobin subunit beta Secreted protein C00025202 4 / 4
P00352 Retinal dehydrogenase 1 Enzyme C00002198 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025202 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025202 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001782 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001782 4 / 3
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00025202 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00025202 0 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein C00025202 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002198 3 / 2
P29466 Caspase-1 C14 C00025202 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001782 1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose C00025196 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00002198 7 / 37
P13866 Sodium/glucose cotransporter 1 Glucose C00025196 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001782 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001782 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001782 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#606824 Glucose/galactose malabsorption; ggm P13866
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#233100 Renal glucosuria; glys1 P31639
#275210 Restrictive dermopathy, lethal P02545
#603903 Sickle cell anemia P68871
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (82)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00022 Bladder cancer P04637 (related)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00001782