Species

KNApSAcK Entry

Organism name Litsea acuminata
Genus Litsea
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Litsea
Linked NCBI taxonomy ID 22042
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00027438 External link 512 Sanjoinine Ib
/ Norisocorydine
CHEMBL465212
No. 20 No. 4
C00027433 External link 512 Laurolitsine
/ (+)-Norboldine
/ (+)-Laurolitsine
CHEMBL487388
C109133
No. 20 No. 4
C00025962 External link 512 Norisoboldine
/ Laurelliptine
/ (+)-Norisoboldine
/ (+)-Laurelliptine
/ (+)-N-Norisoboldine
/ (S)-(+)-Laurelliptine
CHEMBL375902
No. 20 No. 4
C00027409 External link 512 Laurotetanin
/ Laurotetanine
/ (+)-Laurotetanine
CHEMBL464098
C008256
No. 20 No. 4
C00027304 External link 512 Boldine
/ d-Boldine
/ (+)-Boldine
CHEMBL388342
CHEMBL1321247
CHEMBL1437753
C011686
34 / 32 / 35 No. 20 No. 4
C00027440 External link 512 Norjuziphine
/ (-)-Norjusiphine
/ (-)-Norjuziphine
CHEMBL462757
No. 253 No. 4
C00025924 External link 512 Juziphine
/ Yuziphine
/ (+)-Juziphine
CHEMBL462956
No. 253 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00026002 External link 512 Pallidine
/ (-)-Pallidine
/ (-)-Isosalutaridine
No. 426 No. 4

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001869 C00027304 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 C00027304 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001869 C00027304 1 / 2
O00255 Menin Unclassified protein C00001869 C00027304 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 C00027304 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001869 C00027304 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001869 C00027304 4 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 C00027304 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001869 C00027304 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001869 C00027304 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001869 C00027304 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 C00027304 2 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00001869 C00027304 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 C00027304 3 / 3
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 C00027304 1 / 4
Q92830 Histone acetyltransferase KAT2A Enzyme C00027304 0 / 0
O75496 Geminin Unclassified protein C00027304 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00027304 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00027304 1 / 1
P39748 Flap endonuclease 1 Enzyme C00027304 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00027304 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027304 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00027304 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00027304 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P55210 Caspase-7 C14 C00001869 0 / 0
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00027304 1 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00027304 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00027304 0 / 0
P02545 Prelamin-A/C Unclassified protein C00027304 11 / 10
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00027304 0 / 0
P29466 Caspase-1 C14 C00001869 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00027304 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00027304 0 / 0
Q99700 Ataxin-2 Unclassified protein C00027304 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00027304 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00027304 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (69)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)