Species

KNApSAcK Entry

Organism name Miliusa velutina
Genus Miliusa
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Miliusa velutina
Linked NCBI taxonomy ID 235758
Linked level species

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00027153 External link 512 Norcorydine
/ (+)-Norcorydine
CHEMBL494053
No. 20 No. 4
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00027386 External link 512 Isocorydine-N-oxide
/ (+)-Isocorydine N-oxide
No. 286 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 1 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 0 / 1
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001878 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001872 0 / 0
O75496 Geminin Unclassified protein C00001872 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001872 3 / 3
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001872 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#137800 Glioma susceptibility 1; glm1 O75874
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297

KEGG DISEASE (11)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)