Species

KNApSAcK Entry

Organism name Astragalus spp.
Genus Astragalus
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Astragalus
Linked NCBI taxonomy ID 20400
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00010161 External link 512 7,2'-Dihydroxy-3',4'-dimethoxyisoflavone 7-O-glucoside
No. 2 No. 15
C00005134 External link 512 Kaempferol 3-xyloside
CHEMBL518420
CHEMBL477730
No. 2 No. 15
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00009715 External link 512 (+-)-Mucronulatol
/ 7,3'-Dihydroxy-2',4'-dimethoxyisoflavan
CHEMBL253474
CHEMBL478971
CHEMBL1087024
5 / 1 / 0 No. 73 No. 15
C00002075 External link 512 Swainsonine
/ (-)-Swainsonine
CHEMBL63139
CHEMBL292716
CHEMBL302300
CHEMBL65098
CHEMBL371197
D017026
4 / 2 / 4 No. 677 No. 2
C00002050 External link 512 Lentiginosine
CHEMBL63254
C063984
No. 677 No. 2

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00005138 C00009715 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00009715 0 / 0
P43403 Tyrosine-protein kinase ZAP-70 Syk C00002075 1 / 2
P07237 Protein disulfide-isomerase Enzyme C00005138 0 / 0
O43561 Linker for activation of T-cells family member 1 Unclassified protein C00002075 0 / 0
O75496 Geminin Unclassified protein C00009715 0 / 0
P15121 Aldose reductase Enzyme C00005138 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00009715 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005138 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 0 / 0
P14679 Tyrosinase Oxidoreductase C00005138 4 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005138 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005138 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002075 0 / 1
O00754 Lysosomal alpha-mannosidase Enzyme C00002075 1 / 2
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00009715 1 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#137800 Glioma susceptibility 1; glm1 O75874
#248500 Mannosidosis, alpha b, lysosomal; mansa O00754
#269840 Selective t-cell defect; stcd P43403
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (11)

KEGG name UniProt
H00139 alpha-Mannosidosis O00754 (related)
H00422 Glycoproteinoses O00754 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
P43403 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00005 Chronic lymphocytic leukemia (CLL) P43403 (marker)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138