Calanthe discolor Lindl
Species
KNApSAcK Entry
| Organism name | Calanthe discolor Lindl |
|---|---|
| Genus | Calanthe |
| Family | Orchidaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Calanthe |
|---|---|
| Linked NCBI taxonomy ID | 38206 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Orchidaceae |
|---|---|
| ID | 4747 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00026980
|
Calanthoside
/ Glucoindican / Calanthoside A |
No. 128 | No. 72 |
|
||||
|
C00002200
|
Tryptanthrin
/ Tryptanthrine / Couroupitine A |
CHEMBL306946
|
C046243
|
20 / 22 / 23 | 2 / 0 | No. 1798 | No. 7 |
|
|
C00026981
|
Isatin
|
CHEMBL326294
|
D007510
|
8 / 5 / 3 | 12 / 0 | No. 2737 |
|
|
|
C00026982
|
Indirubin
/ Indigo red / Couroupitine B / Indigopurpurin |
CHEMBL259664
CHEMBL1276127 |
C027185
|
16 / 11 / 8 | 40 / 1 | No. 4840 |
|
Human Protein / Gene in interactions
41 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00002200 C00026981 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002200 C00026982 | 4 / 3 |
| P21980 | Protein-glutamine gamma-glutamyltransferase 2 | Enzyme | C00026981 C00026982 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00026982 | 4 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002200 | 11 / 10 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00026981 | 1 / 1 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00026982 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00026982 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002200 | 0 / 1 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | C00026982 | 0 / 0 |
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | C00026982 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002200 | 1 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002200 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00002200 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00026982 | 2 / 3 |
| P17538 | Chymotrypsinogen B | S1A | C00026982 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00026982 | 1 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002200 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002200 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002200 | 2 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002200 | 0 / 3 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002200 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00026981 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002200 | 1 / 2 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00026982 | 0 / 0 |
| P06276 | Cholinesterase | Hydrolase | C00026981 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002200 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002200 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00026981 | 1 / 0 |
| P02766 | Transthyretin | Secreted protein | C00026981 | 3 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002200 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002200 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002200 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002200 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002200 | 0 / 0 |
| P23141 | Liver carboxylesterase 1 | Enzyme | C00026981 | 0 / 0 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00026982 | 0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00026982 | 0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00026982 | 0 / 0 |
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | C00026982 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00026982 | 0 / 0 |
53 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002200
C00026981
|
| 3608 | ILF2, NF45, PRO3063 | interleukin enhancer binding factor 2 |
C00026982
|
| 378 | ARF4, ARF2 | ADP-ribosylation factor 4 |
C00026982
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00026982
|
| 10575 | CCT4, CCT-DELTA, Cctd, SRB | chaperonin containing TCP1, subunit 4 (delta) |
C00026982
|
| 1000 | CDH2, CD325, CDHN, CDw325, NCAD | cadherin 2, type 1, N-cadherin (neuronal) |
C00026982
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00026982
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00026982
|
| 1195 | CLK1, CLK, CLK/STY, STY | CDC-like kinase 1 (EC:2.7.12.1) |
C00026982
|
| 9318 | COPS2, ALIEN, CSN2, SGN2, TRIP15 | COP9 signalosome subunit 2 |
C00026982
|
| 1441 | CSF3R, CD114, GCSFR | colony stimulating factor 3 receptor (granulocyte) |
C00026982
|
| 3577 | CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA | chemokine (C-X-C motif) receptor 1 |
C00026982
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00026982
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00026982
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00026982
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00026982
|
| 3491 | CYR61, CCN1, GIG1, IGFBP10 | cysteine-rich, angiogenic inducer, 61 |
C00026982
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00026982
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00026982
|
| 3281 | HSBP1, NPC-A-13 | heat shock factor binding protein 1 |
C00026982
|
| 3329 | HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 | heat shock 60kDa protein 1 (chaperonin) |
C00026982
|
| 10808 | HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25 | heat shock 105kDa/110kDa protein 1 |
C00026982
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00026982
|
| 3484 | IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1 | insulin-like growth factor binding protein 1 |
C00026982
|
| 3554 | IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 | interleukin 1 receptor, type I |
C00026982
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00026982
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00026982
|
| 3688 | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
C00026982
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00026982
|
| 4258 | MGST2, GST2, MGST-II | microsomal glutathione S-transferase 2 (EC:2.5.1.18) |
C00026982
|
| 4436 | MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2 | mutS homolog 2 |
C00026982
|
| 653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00026982
|
| 4864 | NPC1, NPC | Niemann-Pick disease, type C1 |
C00026982
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00026982
|
| 4735 | SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 | septin 2 |
C00026982
|
| 6514 | SLC2A2, GLUT2 | solute carrier family 2 (facilitated glucose transporter), member 2 |
C00026982
|
| 6688 | SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A | spleen focus forming virus (SFFV) proviral integration oncogene |
C00026982
|
| 6938 | TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20 | transcription factor 12 |
C00026982
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00026982
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00026982
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002200
|
| 36 | ACADSB, 2-MEBCAD, ACAD7, SBCAD | acyl-CoA dehydrogenase, short/branched chain (EC:1.3.8.5) |
C00026982
|
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00026981
|
| 8574 | AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) |
C00026981
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00026981
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00026981
|
| 874 | CBR3, SDR21C2, hCBR3 | carbonyl reductase 3 (EC:1.1.1.184) |
C00026981
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00026981
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00026981
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00026981
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00026981
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00026981
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00026981
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (34)
| OMIM | preferred title | UniProt |
|---|---|---|
| #105210 | Amyloidosis, hereditary, transthyretin-related |
P02766
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #115430 | Carpal tunnel syndrome; cts1 |
P02766
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #145680 | Dystransthyretinemic euthyroidal hyperthyroxinemia |
P02766
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (31)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00798 | Familial carpal tunnel syndrome |
P02766
(related)
|
| H00845 | Familial amyloidosis |
P02766
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|