PCIDB

Veratrum lobelianum

Family in NCBI taxonomy	Melanthiaceae
ID	50362

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class	Liliopsida
ID	4447

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster
C00028946	Rubijervine	CHEMBL1512978 CHEMBL1993702		5 / 2 / 3		No. 265	No. 11
C00029205	Verazine	CHEMBL458682 CHEMBL457588	C052979			No. 265	No. 11
C00028412	Isorubijervine					No. 265	No. 11
C00029184	Veracintine					No. 265	No. 11
C00028299	Germinaline					No. 321	No. 11
C00028301	Germinine					No. 321	No. 11
C00028297	Germerine		C427629			No. 321	No. 11
C00029204	Veratroylzygadenine					No. 321	No. 11
C00029202	Veratrine	CHEMBL439496 CHEMBL451227 CHEMBL1363612 CHEMBL1710967	D014701	11 / 6 / 8	0 / 1	No. 321	No. 11
C00028302	Germitetrine					No. 321	No. 11
C00028296	Germbudine					No. 321	No. 11
C00029191	Veralosine					No. 520
C00028413	Isorubijervosine					No. 520
C00002253	Jervine	CHEMBL186779 CHEMBL1402135 CHEMBL1717145 CHEMBL1742371	C010206	11 / 15 / 12		No. 587	No. 11
C00029209	Verdine					No. 587	No. 11
C00029095	Tetrahydroveralkamine					No. 1197	No. 11
C00028175	Diacetylveralkamine / O,O-Diacetylveralkamine					No. 1844	No. 11
C00029189	Veralomidine					No. 1844	No. 11
C00029210	Verdinine					No. 2484
C00029190	Veralomine					No. 3567
C00028870	Pseudojervine / Jervine 3-O-beta-D-glucopyranoside / 3beta-(D-glucopyranosyloxy)-jervine					No. 3567
C00029188	Veralodine	CHEMBL1516073		3 / 3 / 7		No. 5375
C00028401	Isojervine					No. 7666

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002253 C00028946 C00029202	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002253 C00028946 C00029202	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002253 C00028946 C00029202	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002253 C00028946 C00029202	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002253 C00028946 C00029202	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00029202	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002253	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00002253	1 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00029202	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002253	7 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00029188	0 / 0
Q15465	Sonic hedgehog protein	Unclassified protein	C00002253	4 / 5
P16473	Thyrotropin receptor	Glycohormone receptor	C00029202	3 / 2
Q15125	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	C00002253	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00002253	0 / 0
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00029202	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00029202	0 / 0
O00255	Menin	Unclassified protein	C00029188	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00029188	1 / 2
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00029202	0 / 3

OMIM	preferred title	UniProt
#219080	Acth-independent macronodular adrenal hyperplasia; aimah	P63092
#608688	Aicar transformylase/imp cyclohydrolase deficiency	P31939
#614373	Amyotrophic lateral sclerosis 16, juvenile; als16	Q99720
#302960	Chondrodysplasia punctata 2, x-linked dominant; cdpx2	Q15125
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#605130	Hairy elbows, short stature, facial dysmorphism, and developmental delay	Q03164
#142945	Holoprosencephaly 3; hpe3	Q15465
#145000	Hyperparathyroidism 1; hrpt1	O00255
#603373	Hyperthyroidism, familial gestational	P16473
#609152	Hyperthyroidism, nonautoimmune	P16473
#275200	Hypothyroidism, congenital, nongoitrous, 1; chng1	P16473
#174800	Mccune-albright syndrome; mas	P63092
#611638	Microphthalmia, isolated, with coloboma 5; mcopcb5	Q15465
#131100	Multiple endocrine neoplasia, type i; men1	O00255
#166350	Osseous heteroplasia, progressive; poh	P63092
#102200	Pituitary adenoma, growth hormone-secreting	P63092
#174500	Polydactyly, preaxial ii; ppd2	Q15465
#103580	Pseudohypoparathyroidism, type ia; php1a	P63092
#603233	Pseudohypoparathyroidism, type ib; php1b	P63092
#612462	Pseudohypoparathyroidism, type ic; php1c	P63092
#147250	Solitary median maxillary central incisor; smmci	Q15465

KEGG	name	UniProt
H00033	Adrenal carcinoma	O00255 (related)
H00034	Carcinoid	O00255 (related)
H00045	Malignant islet cell carcinoma	O00255 (related)
H00246	Primary hyperparathyroidism	O00255 (related)
H01102	Pituitary adenomas	O00255 (related)
H00081	Hashimoto's thyroiditis	P01215 (marker)
H00082	Graves' disease	P01215 (marker)
H00250	Congenital nongoitrous hypothyroidism (CHNG)	P01215 (marker) P16473 (related)
H00036	Osteosarcoma	P08684 (marker)
H01205	Coumarin resistance	P11712 (related)
H01269	Congenital hyperthyroidism	P16473 (related)
H00966	AICA-ribosiduria	P31939 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)
H00244	Pseudohypoparathyroidism	P63092 (related)
H00441	Progressive osseous heteroplasia (POH)	P63092 (related)
H00501	Fibrous dysplasia, polyostotic	P63092 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Q03164 (related) Q03164 (marker)
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Q03164 (related)
H01194	X-linked chondrodysplasia punctata	Q15125 (related)
H00039	Basal cell carcinoma	Q15465 (related)
H00267	Holoprosencephaly (HPE)	Q15465 (related)
H00652	Solitary median maxillary central incisor syndrome	Q15465 (related)
H01027	Anophthalmia and microphthalmia (A/M)	Q15465 (related)
H01160	Schizencephaly	Q15465 (related)

MESH or OMIM	name	KNApSAcK metabolite
D001919	Bradycardia	C00029202