Species

KNApSAcK Entry

Organism name Cedrelopsis grevei
Genus Cedrelopsis
Family Meliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cedrelopsis grevei
Linked NCBI taxonomy ID 864332
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003738 External link 512 beta-Amyrin
/ beta-Amirin
/ beta-Amyrine
/ beta-Amyrenol
C036380
0 / 4 No. 23 No. 51
C00014447 External link 512 Cedreprenone
/ (2E)-1-(5-Hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one
No. 130
C00014445 External link 512 2'-Methoxyhelikrausichalcone
/ 6'',6''-Dimethyl-5''-hydroxy-4'',5''-dihydropyrano[2'',3'':4',3']-2'-hydroxy-6'-methoxychalcone
No. 337
C00036121 External link 512 Heteropeucenin
No. 719
C00036196 External link 512 Peucenin
CHEMBL1415085
1 / 2 / 2 No. 719
C00036202 External link 512 Ptaeroxylin
CHEMBL1527943
7 / 6 / 6 No. 719
C00036084 External link 512 Cedrecoumarin A
CHEMBL491519
2 / 1 / 1 No. 750 No. 25
C00002498 External link 512 Scoparone
/ 6,7-Dimethoxycoumarin
/ Aesculetin dimethyl ether
CHEMBL325864
C018145
4 / 2 / 2 6 / 0 No. 864 No. 25
C00014442 External link 512 Cedrediprenone
/ 2',4'-Dihydroxy-3'-prenyl-5''-(2-hydroxyisopropyl)-4'',5''-dihydrofurano[2'',3'':6',5']chalcone
No. 966
C00036033 External link 512 Alloptaeroxylin
No. 1000 No. 15
C00002436 External link 512 5-O-Methylalloptaeroxylin
CHEMBL2164965
No. 1000 No. 15
C00002442 External link 512 Ptaeroglycol
No. 1000 No. 15
C00030428 External link 512 Greveichromenol
CHEMBL2204368
No. 1000 No. 15
C00036120 External link 512 Greveiglycol
No. 1426 No. 15
C00036082 External link 512 Cedashnine
No. 5584
C00036083 External link 512 Cedmiline
No. 5584

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00036196 C00036202 2 / 2
P03372 Estrogen receptor NR3A1 C00036084 1 / 1
Q92731 Estrogen receptor beta NR3A2 C00036084 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00036202 0 / 0
P56817 Beta-secretase 1 A1A C00002498 0 / 0
P05091 Aldehyde dehydrogenase, mitochondrial Oxidoreductase C00002498 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00036202 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00036202 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00036202 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00036202 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00036202 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00002498 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002498 1 / 1

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002498
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002498
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00002498
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00002498
5966 REL, C-Rel v-rel avian reticuloendotheliosis viral oncogene homolog C00002498
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002498

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#610251 Alcohol sensitivity, acute P05091
#300615 Brunner syndrome P21397
#119900 Digital clubbing, isolated congenital P15428
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (9)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H01071 Acute alcohol sensitivity P05091 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005157 Facial Pain C00003738
D006930 Hyperalgesia C00003738
D007249 Inflammation C00003738
D010146 Pain C00003738