PCIDB

Calophyllum bracteatum

Species

KNApSAcK Entry

Organism name Calophyllum bracteatum
Genus Calophyllum
Family Calophyllaceae / Clusiaceae / Clusiaceae-Guttiferae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Calophyllum
Linked NCBI taxonomy ID 73121
Linked level genus

Family

Family in NCBI taxonomy Calophyllaceae
ID 703253

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00037921 External link 512 Tovopyrifolin C
/ 1,3,5-Trihydroxy-2-methoxyxanthone
CHEMBL186433
1 / 1 / 1 No. 3 No. 15
C00036378 External link 512 Haploxanthone
/ 1,3,7-Trihydroxy-8-methoxyxanthone
No. 3 No. 15
C00032287 External link 512 Taraxerone
CHEMBL519077
CHEMBL1990874
C009379
No. 13 No. 51
C00003758 External link 512 Alnulin
/ Tiliadin
/ Skimmiol
/ Taraxerol
CHEMBL511822
CHEMBL470462
C005802
No. 13 No. 51
C00002944 External link 512 Calophyllin B
No. 15 No. 15
C00002959 External link 512 Jacareubin
CHEMBL1254294
No. 24 No. 15
C00002947 External link 512 6-Deoxyjacareubin
CHEMBL457949
No. 24 No. 15
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00033518 External link 512 1,5-Dihydroxyxanthone
CHEMBL185686
1 / 1 / 1 No. 76 No. 15
C00029364 External link 512 Euxanthone
/ 1,7-Dihydroxyxanthone
CHEMBL389166
C404221
1 / 0 / 0 No. 76 No. 15
C00002455 External link 512 Calophyllolide
C018859
No. 464 No. 17

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00033518 C00037921 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P35610 Sterol O-acyltransferase 1 Enzyme C00029364 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#300615 Brunner syndrome P21397
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (13)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)