| Organism name | Crataegus oxyacantha |
|---|---|
| Genus | Crataegus |
| Family | Rosaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Crataegus rhipidophylla |
|---|---|
| Linked NCBI taxonomy ID | 510738 |
| Linked level | species |
| Family in NCBI taxonomy | Rosaceae |
|---|---|
| ID | 3745 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00002935
|
Procyanidin B4
/ Catechin-(4alpha->8)-epicatechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
20 / 7 / 8 | No. 16 | No. 19 |
|
||
|
C00009098
|
Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin |
CHEMBL290632
|
13 / 5 / 6 | No. 29 | No. 19 |
|
||
|
C00009107
|
Cinnamtannin A1
|
No. 113 | No. 19 |
|
||||
|
C00002472
|
Esculin
|
CHEMBL359043
CHEMBL482581 CHEMBL1434042 CHEMBL1515174 CHEMBL1536019 CHEMBL1619714 CHEMBL1624854 |
D004929
|
22 / 18 / 24 | 0 / 1 | No. 491 | No. 25 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002472 C00002935 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00002935 C00009098 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00002935 C00009098 | 1 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00002935 C00009098 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00002935 C00009098 | 1 / 1 |
| Q05655 | Protein kinase C delta type | Delta | C00002935 C00009098 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002472 C00002935 | 0 / 1 |
| P17252 | Protein kinase C alpha type | Alpha | C00002935 C00009098 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00002935 C00009098 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00002935 C00009098 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00002935 C00009098 | 0 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00002935 C00009098 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002472 C00002935 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002472 C00002935 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002472 C00002935 | 3 / 3 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002472 C00002935 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00002935 C00009098 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00009098 | 1 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002472 | 2 / 2 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00002935 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002935 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002472 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002472 | 1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002472 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002472 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002472 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002472 | 1 / 2 |
| P42226 | Signal transducer and activator of transcription 6 | Unclassified protein | C00002472 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002472 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002472 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002472 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002472 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00009098 | 2 / 2 |
| P29466 | Caspase-1 | C14 | C00002472 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002472 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00002472 | 6 / 4 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002472 | 0 / 3 |
| P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | C00002935 | 0 / 0 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #301500 | Fabry disease |
P06280
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00028 | Choriocarcinoma |
P08253
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|