Species

KNApSAcK Entry

Organism name Crataegus oxyacantha
Genus Crataegus
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Crataegus rhipidophylla
Linked NCBI taxonomy ID 510738
Linked level species

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002935 External link 512 Procyanidin B4
/ Catechin-(4alpha->8)-epicatechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
20 / 7 / 8 No. 16 No. 19
C00009098 External link 512 Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin
CHEMBL290632
13 / 5 / 6 No. 29 No. 19
C00009107 External link 512 Cinnamtannin A1
No. 113 No. 19
C00002472 External link 512 Esculin
CHEMBL359043
CHEMBL482581
CHEMBL1434042
CHEMBL1515174
CHEMBL1536019
CHEMBL1619714
CHEMBL1624854
D004929
22 / 18 / 24 0 / 1 No. 491 No. 25

Human Protein / Gene in interactions

38 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002472 C00002935 1 / 0
P41743 Protein kinase C iota type Iota C00002935 C00009098 0 / 0
P24723 Protein kinase C eta type Eta C00002935 C00009098 1 / 0
P05771 Protein kinase C beta type Alpha C00002935 C00009098 0 / 0
P05129 Protein kinase C gamma type Alpha C00002935 C00009098 1 / 1
Q05655 Protein kinase C delta type Delta C00002935 C00009098 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002472 C00002935 0 / 1
P17252 Protein kinase C alpha type Alpha C00002935 C00009098 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002935 C00009098 0 / 0
Q02156 Protein kinase C epsilon type Eta C00002935 C00009098 0 / 0
Q04759 Protein kinase C theta type Delta C00002935 C00009098 0 / 1
Q05513 Protein kinase C zeta type Iota C00002935 C00009098 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002472 C00002935 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002472 C00002935 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002472 C00002935 3 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002472 C00002935 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002935 C00009098 0 / 0
P08253 72 kDa type IV collagenase M10A C00009098 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002472 2 / 2
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00002935 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002935 0 / 0
P55210 Caspase-7 C14 C00002472 0 / 0
P06280 Alpha-galactosidase A Enzyme C00002472 1 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002472 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002472 0 / 0
O00255 Menin Unclassified protein C00002472 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002472 1 / 2
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00002472 0 / 0
O75496 Geminin Unclassified protein C00002472 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002472 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002472 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002472 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00009098 2 / 2
P29466 Caspase-1 C14 C00002472 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002472 1 / 1
P04062 Glucosylceramidase Enzyme C00002472 6 / 4
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002472 0 / 3
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00002935 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#168600 Parkinson disease, late-onset; pd P04062
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723

KEGG DISEASE (29)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D013272 Stomach Diseases C00002472