KNApSAcK Entry

Organism name Fagara tessmannii Engl.
Genus Fagara
Family Rutaceae
Kingdom Plantae

NCBI taxonomy


Linked NCBI taxonomy name Rutaceae
Linked NCBI taxonomy ID 23513
Linked level family


Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00003741 External link 512 Betulinic acid
34 / 17 / 14 10 / 2 No. 23 No. 51
C00034389 External link 512 3beta-Acetoxy-16beta-hydroxybetulinic acid
No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
3 / 0 / 0 2 / 6 No. 23 No. 51
C00034388 External link 512 3beta,16beta-Diacetoxybetulinic acid
No. 23 No. 51
C00003647 External link 512 Campesterol
/ 24alpha-Methylcholesterol
/ (24R)24-Methylcholest-5-en-3beta-ol
No. 53 No. 11
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
17 / 19 / 12 No. 53 No. 11
C00003674 External link 512 Stigmasterol
/ beta-Stigmasterol
5 / 0 / 0 1 / 0 No. 53 No. 11
C00032163 External link 512 Sitostanol
/ Stigmastanol
/ beta-Sitostanol
No. 68 No. 11
C00034417 External link 512 (-)-Arcitin
/ Arctigenin methyl ether
No. 223 No. 21
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
5 / 3 / 3 5 / 0 No. 1073
C00000258 External link 512 2,6-Dimethoxy-p-benzoquinone
22 / 32 / 55 No. 2517

Human Protein / Gene in interactions

65 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000258 C00003672 C00003741 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00003674 C00003741 C00003749 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 C00003674 C00003741 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 C00003741 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 C00003741 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 C00003741 2 / 0
P03372 Estrogen receptor NR3A1 C00002682 C00003672 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000258 C00002682 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 C00003741 1 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000258 C00003741 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000258 C00003741 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00003749 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 C00003741 0 / 0
P15121 Aldose reductase Enzyme C00002682 C00003741 0 / 0
O75496 Geminin Unclassified protein C00000258 C00003741 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000258 C00003741 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00003741 C00003749 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 C00003741 0 / 1
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00003741 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00000258 2 / 3
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003741 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000258 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00003741 0 / 0
P42858 Huntingtin Unclassified protein C00002682 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000258 2 / 0
Q02156 Protein kinase C epsilon type Eta C00003741 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00003674 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P02545 Prelamin-A/C Unclassified protein C00003741 11 / 10
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000258 7 / 3
Q04206 Transcription factor p65 Transcription Factor C00003741 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003741 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000258 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003741 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
Q96RI1 Bile acid receptor NR1H4 C00003741 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00003741 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000258 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003741 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00003741 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003741 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00003674 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003741 0 / 0
P05771 Protein kinase C beta type Alpha C00003741 0 / 0
P51580 Thiopurine S-methyltransferase Enzyme C00002682 1 / 1
Q99700 Ataxin-2 Unclassified protein C00000258 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00000258 4 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00000258 7 / 37
P10636 Microtubule-associated protein tau Unclassified protein C00000258 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000258 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00003741 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000258 0 / 0
Q2TB90 Putative hexokinase HKDC1 Enzyme C00000258 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003741 0 / 0
O00255 Menin Unclassified protein C00000258 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000258 1 / 2
Q02880 DNA topoisomerase 2-beta Isomerase C00003674 0 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00003741 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00003741 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000258 2 / 1

18 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC: C00003741
581 BAX, BCL2L4 BCL2-associated X protein C00003741
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00003741
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC: C00003741
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC: C00003741
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC: C00003741
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC: C00003741
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC: C00003741
7150 TOP1, TOPI topoisomerase (DNA) I (EC: C00003741
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC: C00003741
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC: C00003749
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00003674
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC: C00002682
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC: C00002682
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC: C00002682
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC: C00002682
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC: C00002682

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (65)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#610460 Thiopurine s-methyltransferase deficiency P51580
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253


KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

D008103 Liver Cirrhosis C00003741
D008545 Melanoma C00003741
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749