Species

KNApSAcK Entry

Organism name Derris indica
Genus Derris
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Derris
Linked NCBI taxonomy ID 53864
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005082 External link 512 Pongachromene
/ 2-(1,3-Benzodioxol-5-yl)-3-methoxy-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
/ 3-Methoxy-8,8-dimethyl-2-[3,4-(methylenedioxy)phenyl]-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
CHEMBL573848
No. 24 No. 15
C00005072 External link 512 Pongaflavone
/ Karanjachromene
/ 3-Methoxy-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
CHEMBL2204384
No. 24 No. 15
C00034884 External link 512 Pachycarin D
No. 35 No. 15
C00013444 External link 512 Pinnatin
/ 4-Methoxy-7-phenyl-5H-furo[3,2-g][1]benzopyran-5-one
CHEMBL395770
No. 35 No. 15
C00013348 External link 512 3,7-Dimethoxyflavone
/ 3,7-Dimethoxy-2-phenyl-4H-1-benzopyran-4-one
CHEMBL1449187
13 / 23 / 24 No. 35 No. 15
C00005089 External link 512 Karanjin
/ 3-Methoxy-2-phenyl-4H-Furo[2,3-h]-1-benzopyran-4-one
CHEMBL208484
C052068
20 / 21 / 18 No. 35 No. 15
C00002546 External link 512 Inermin
/ Maackiain
/ (-)-Maackiain
/ Demethylpterocarpin
/ 3-Hydroxy-8,9-methylenedioxypterocarpan
CHEMBL334918
CHEMBL239047
CHEMBL445279
3 / 2 / 3 No. 66 No. 15

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002546 C00005089 C00013348 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00005089 C00013348 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005089 C00013348 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005089 C00013348 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00005089 C00013348 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00005089 C00013348 3 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00005089 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00013348 3 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00005089 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00013348 2 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00005089 1 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00013348 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005089 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00005089 7 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00005089 3 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00013348 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005089 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005089 0 / 0
P04062 Glucosylceramidase Enzyme C00013348 6 / 4
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005089 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00005089 1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose C00002546 1 / 1
P13866 Sodium/glucose cotransporter 1 Glucose C00002546 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00005089 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005089 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00005089 0 / 0
O00255 Menin Unclassified protein C00013348 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00013348 1 / 2
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005089 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#606824 Glucose/galactose malabsorption; ggm P13866
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#233100 Renal glucosuria; glys1 P31639
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (35)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)