Species

KNApSAcK Entry

Organism name Populus balsamifera
Genus Populus
Family Salicaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Populus balsamifera
Linked NCBI taxonomy ID 73824
Linked level species

Family

Family in NCBI taxonomy Salicaceae
ID 3688

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00007937 External link 512 2',4',6'-Trihydroxy-4-methoxydihydrochalcone
No. 90 No. 13
C00007929 External link 512 2',6'-Dihydroxy-4'-methoxydihydrochalcone
CHEMBL486009
No. 90 No. 13
C00007928 External link 512 2',4',6'-Trihydroxydihydrochalcone
/ 3-Phenyl-1-(2,4,6-trihydroxyphenyl)-1-propanone
CHEMBL503375
8 / 5 / 4 No. 90 No. 13
C00003103 External link 512 (+)-alpha-Bisabolol
CHEMBL519167
CHEMBL491186
CHEMBL477832
CHEMBL1096927
CHEMBL1171719
CHEMBL1561544
CHEMBL2104360
8 / 4 / 13 No. 541 No. 38
C00002685 External link 512 Acetophenone
CHEMBL274467
C038699
2 / 0 / 0 2 / 0 No. 2578 No. 9

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003103 0 / 3
P10253 Lysosomal alpha-glucosidase Hydrolase C00007928 1 / 1
Q96LD8 Sentrin-specific protease 8 Enzyme C00007928 0 / 0
Q13464 Rho-associated protein kinase 1 Rock C00002685 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00002685 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00003103 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00007928 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003103 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00003103 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003103 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003103 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00007928 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00007928 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00007928 4 / 3
O00255 Menin Unclassified protein C00003103 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003103 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00007928 0 / 0
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00007928 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00002685
250 ALPP, ALP, PALP, PLAP, PLAP-1 alkaline phosphatase, placental (EC:3.1.3.1) C00002685

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (17)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)