Species

KNApSAcK Entry

Organism name Alpinia speciosa
Genus Alpinia
Family Zingiberaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Etlingera elatior
Linked NCBI taxonomy ID 188493
Linked level species

Family

Family in NCBI taxonomy Zingiberaceae
ID 4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006936 External link 512 Flavokawin B
CHEMBL104255
19 / 31 / 55 No. 79
C00007931 External link 512 Dihydroflavokawin B
CHEMBL492166
No. 90 No. 13
C00002987 External link 512 5,6-Dehydrokawain
CHEMBL254218
C052297
12 / 16 / 44 No. 1312 No. 63
C00023387 External link 512 15,16-Dinor-8(17),11E-labdadien-13-one
CHEMBL2332436
2 / 0 / 1 No. 2256
C00010825 External link 512 Isocineple
/ 1,4-Cineole
C058951
No. 4112 No. 35

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00002987 C00006936 7 / 37
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002987 C00006936 0 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00006936 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00006936 0 / 0
Q99700 Ataxin-2 Unclassified protein C00006936 1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002987 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00006936 1 / 4
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002987 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00006936 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002987 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006936 2 / 0
O75496 Geminin Unclassified protein C00006936 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00006936 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00006936 7 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006936 1 / 2
Q16637 Survival motor neuron protein Unclassified protein C00002987 4 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00006936 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00002987 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00006936 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00006936 2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002987 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002987 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00006936 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00023387 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00006936 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00006936 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002987 0 / 0
P10275 Androgen receptor NR3C4 C00002987 3 / 4
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00023387 0 / 1
P35869 Aryl hydrocarbon receptor Transcription Factor C00002987 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00006936 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#208900 Ataxia-telangiectasia; at Q13315
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (63)

KEGG name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
Q13315 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00408 Type I diabetes mellitus P17706 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)