PCIDB

Perovskia scrophularifolia

Species

KNApSAcK Entry

Organism name Perovskia scrophularifolia
Genus Perovskia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Perovskia
Linked NCBI taxonomy ID 39175
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00029329 External link 512 Roseoside
/ Roseoside A
/ Roseoside II
/ (6S,9R)-Roseoside
/ Vomifoliol beta-D-glucopyranoside
C00031274 External link 512 Salidroside
/ Rhodioloside
/ (-)-Rhodioloside
/ Tyrosol alpha-(beta-D-glucopyranoside)
CHEMBL465208
CHEMBL1899113
C009172
3 / 0 / 0 No. 45 No. 72
C00030227 External link 512 Eugenol glucoside
/ Eugenol beta-D-glucopyranoside
CHEMBL463487
No. 45 No. 72
C00029387 External link 512 12-O-methylcarnosic acid
/ 12-O-Methyl carnosic acid
/ (+)-12-O-Methyl carnosic acid
/ Carnosic acid 12-methyl ether
CHEMBL1096627
No. 323 No. 41
C00030193 External link 512 Epirosmanol
CHEMBL507166
No. 734 No. 40
C00003410 External link 512 Carnosol
CHEMBL218693
CHEMBL1514916
C068623
17 / 17 / 17 12 / 0 No. 734 No. 40
C00031191 External link 512 Rosmanol
No. 734 No. 40
C00019674 External link 512 Uridine
CHEMBL68846
CHEMBL100259
CHEMBL265701
CHEMBL608294
CHEMBL609651
CHEMBL1092065
CHEMBL2093066
D014529
5 / 0 / 3 7 / 15 No. 2366

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00003410 C00019674 C00031274 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003410 C00031274 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003410 2 / 0
Q9Y5X4 Photoreceptor-specific nuclear receptor NR2E3 C00003410 2 / 2
P37840 Alpha-synuclein Unclassified protein C00003410 4 / 2
P11473 Vitamin D3 receptor NR1I1 C00003410 2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00031274 0 / 0
P27708 CAD protein Enzyme C00019674 0 / 0
P39748 Flap endonuclease 1 Enzyme C00003410 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003410 0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme C00003410 1 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019674 0 / 3
Q99700 Ataxin-2 Unclassified protein C00003410 1 / 1
Q9HA47 Uridine-cytidine kinase 1 Enzyme C00019674 0 / 0
P16233 Pancreatic triacylglycerol lipase Hydrolase C00003410 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003410 2 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003410 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00019674 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00003410 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003410 0 / 0
O00255 Menin Unclassified protein C00003410 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003410 1 / 2

19 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00003410
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003410
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00003410
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00003410
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00003410
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00003410
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003410
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00003410
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00003410
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00003410
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00003410
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00003410
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00019674
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00019674
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00019674
9154 SLC28A1, CNT1, HCNT1 solute carrier family 28 (concentrative nucleoside transporter), member 1 C00019674
9153 SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 solute carrier family 28 (concentrative nucleoside transporter), member 2 C00019674
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00019674
3177 SLC29A2, DER12, ENT2, HNP36 solute carrier family 29 (equilibrative nucleoside transporter), member 2 C00019674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#268100 Enhanced s-cone syndrome; escs Q9Y5X4
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#611131 Retinitis pigmentosa 37; rp37 Q9Y5X4
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (20)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00527 Retinitis pigmentosa (RP) Q9Y5X4 (related)
H00805 Vitreoretinal degeneration Q9Y5X4 (related)

Diseases related to CTD interactions

15 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000015 Abnormalities, Multiple C00019674
D000749 Anemia, Megaloblastic C00019674
D001919 Bradycardia C00019674
D002375 Catalepsy C00019674
D004342 Drug Hypersensitivity C00019674
D056486 Drug-Induced Liver Injury C00019674
D064420 Drug-Related Side Effects and Adverse Reactions C00019674
D005234 Fatty Liver C00019674
D007022 Hypotension C00019674
D028361 Mitochondrial Diseases C00019674
C538525 Mitochondrial encephalopathy C00019674
D017240 Mitochondrial Myopathies C00019674
D010523 Peripheral Nervous System Diseases C00019674
D011565 Psoriasis C00019674
D019956 Stereotypic Movement Disorder C00019674