Species

KNApSAcK Entry

Organism name Salvia syriaca L.
Genus Salvia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvia
Linked NCBI taxonomy ID 21880
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00003558 External link 512 Ursolic acid
CHEMBL297810
CHEMBL56048
CHEMBL300594
CHEMBL169
CHEMBL176234
CHEMBL491715
CHEMBL1316667
CHEMBL1555307
CHEMBL1593360
CHEMBL1979720
C005466
47 / 26 / 33 15 / 12 No. 13 No. 51
C00003840 External link 512 Salvigenin
CHEMBL376644
C014049
No. 35 No. 15
C00029593 External link 512 7-Oxo-beta-sitosterol
/ 3beta-Hydroxystigmast-5-en-7-one
CHEMBL254780
CHEMBL483850
C071711
No. 53 No. 11
C00023770 External link 512 Sitosterol
/ Stigmasta-5,22-dien-3beta-ol
/ (24R)24-Ethylcholesta-5,22-dien-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00003426 External link 512 Ferruginol
CHEMBL197308
No. 359 No. 40
C00035944 External link 512 Salvisyrianone
/ 3-Oxosaprorthoquinone
CHEMBL328722
No. 2154
C00036081 External link 512 Candidissiol
No. 2796
C00036243 External link 512 Viridone
No. 2989
C00036012 External link 512 4-Dehydrosalvilimbinol
/ (-)-4-Dehydrosalvilimbinol
No. 5547

Human Protein / Gene in interactions

62 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003558 C00019064 C00023770 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003558 C00019064 C00023770 0 / 0
P06746 DNA polymerase beta Enzyme C00003558 C00019064 C00023770 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00003558 C00019064 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003558 C00019064 0 / 3
Q01196 Runt-related transcription factor 1 Unclassified protein C00003558 C00019064 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00003558 C00019064 0 / 1
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00003558 C00019064 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003558 C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003558 C00019064 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003558 C00023770 1 / 1
P08047 Transcription factor Sp1 Unclassified protein C00003558 C00023770 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00003558 C00019064 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003558 C00019064 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003558 C00019064 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003558 C00023770 0 / 1
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003558 C00023770 0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003558 C00019064 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003558 C00023770 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003558 C00023770 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003558 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P15121 Aldose reductase Enzyme C00003558 C00019064 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003558 C00023770 1 / 0
Q96RI1 Bile acid receptor NR1H4 C00003558 C00019064 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003558 C00019064 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003558 C00019064 2 / 2
P14679 Tyrosinase Oxidoreductase C00023770 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003558 0 / 0
P00734 Prothrombin S1A C00023770 4 / 2
Q04206 Transcription factor p65 Transcription Factor C00003558 0 / 0
O15379 Histone deacetylase 3 Hydrolase C00003558 0 / 0
O75496 Geminin Unclassified protein C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
Q9UQL6 Histone deacetylase 5 Hydrolase C00003558 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00019064 0 / 0
P03372 Estrogen receptor NR3A1 C00023770 1 / 1
P56524 Histone deacetylase 4 Hydrolase C00003558 1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003558 0 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00003558 0 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00003558 1 / 1
P08183 Multidrug resistance protein 1 drug C00023770 1 / 0
Q9UNA4 DNA polymerase iota Enzyme C00019064 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003558 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003558 3 / 1
Q9UBN7 Histone deacetylase 6 Hydrolase C00003558 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00023770 3 / 2
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003558 11 / 10
Q13547 Histone deacetylase 1 Hydrolase C00003558 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003558 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00023770 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003558 1 / 0
O00255 Menin Unclassified protein C00003558 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003558 1 / 2
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 4 / 2
P49798 Regulator of G-protein signaling 4 Unclassified protein C00023770 2 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00003558 0 / 0

31 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003558 C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003558 C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003558 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003558 C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003558 C00019064
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00003558
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003558
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00003558
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00003558
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003558
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003558
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00003558
581 BAX, BCL2L4 BCL2-associated X protein C00003558
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00003558
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003558
847 CAT catalase (EC:1.11.1.6) C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (47)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600430 Brachydactyly-mental retardation syndrome; bdmr P56524
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#156250 Metachondromatosis; metcds Q06124
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#163950 Noonan syndrome 1; ns1 Q06124
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35228 (related)
P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00561 Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome P56524 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

22 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006949 Hyperlipidemias C00003558
C00019064
D009369 Neoplasms C00003558
C00019064
D017202 Myocardial Ischemia C00003558
C00019064
D008103 Liver Cirrhosis C00003558
C00019064
D007249 Inflammation C00003558
C00019064
D012878 Skin Neoplasms C00003558
D006965 Hyperplasia C00003558
D006943 Hyperglycemia C00003558
D003921 Diabetes Mellitus, Experimental C00003558
D002471 Cell Transformation, Neoplastic C00003558
D006528 Carcinoma, Hepatocellular C00003558
D001284 Atrophy C00003558
D002252 Carbon Tetrachloride Poisoning C00019064
D056486 Drug-Induced Liver Injury C00019064
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D007674 Kidney Diseases C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064