KEGG   ENZYME: 2.1.1.354Help
Entry
EC 2.1.1.354                Enzyme                                 

Name
[histone H3]-lysine4 N-trimethyltransferase;
KMT2A (gene name);
KMT2B (gene name);
KMT2C (gene name);
KMT2D (gene name);
KMT2E (gene name);
KMT2F (gene name);
KMT2G (gene name);
KMT2H (gene name);
KMT3C (gene name);
KMT3D (gene name);
KMT3E (gene name);
KMT7 (gene name);
PRDM7 (gene name);
PRDM9 (gene name);
MLL1 (gene name);
MLL2 (gene name);
MLL3 (gene name);
MLL4 (gene name);
MLL5 (gene name);
SETD1A (gene name);
ASH1L (gene name);
SMYD1 (gene name);
SMYD2 (gene name);
SMYD3 (gene name);
SET7/9 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Comment
This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. Unlike the other enzymes, KMT7 catalyses only monomethylation.
History
EC 2.1.1.354 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.354
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD
K11431  [histone H3]-lysine4 N-trimethyltransferase SETD7
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3
Genes
HSA: 11105(PRDM7) 150572(SMYD1) 23067(SETD1B) 4297(KMT2A) 55870(ASH1L) 55904(KMT2E) 56950(SMYD2) 56979(PRDM9) 58508(KMT2C) 64754(SMYD3) 8085(KMT2D) 80854(SETD7) 9739(SETD1A) 9757(KMT2B)
PTR: 100610362(KMT2D) 107971434(ASH1L) 451587(KMT2A) 455959(KMT2B) 457729(SMYD2) 457870(SMYD3) 459386(SMYD1) 461944(PRDM9) 463640(KMT2E) 463875(KMT2C) 468101(SETD1A) 473295(SETD1B) 737682(SETD7)
PPS: 100971786(SMYD2) 100972983(SETD1A) 100979249(KMT2B) 100979709(ASH1L) 100981554(SETD7) 100982828(KMT2E) 100983230(SMYD1) 100984332(KMT2A) 100985657(SETD1B) 100990317(SMYD3) 100992231(KMT2C) 100993054(PRDM9) 100995808(KMT2D)
GGO: 101124677(SETD1B) 101126745(SETD1A) 101129366(KMT2A) 101134264(ASH1L) 101134599(KMT2C) 101135995(PRDM7) 101136369(PRDM9) 101136477(SETD7) 101139923(KMT2B) 101144774(KMT2D) 101144971(KMT2E) 101145998(SMYD3) 101146341(SMYD1) 101147890(SMYD2)
PON: 100172280(SMYD1) 100173903(KMT2E) 100432076(SETD1A) 100435324(SETD1B) 100439269(SMYD3) 100439693(PRDM9) 100439768(SMYD2) 100440639(PRDM7) 100441102(KMT2A) 100441715(KMT2D) 100442005(KMT2B) 100449956(SETD7)
NLE: 100579604(SMYD3) 100580011(ASH1L) 100583589(PRDM9) 100584028(SETD1B) 100586637(KMT2D) 100594433(KMT2B) 100600051(KMT2E) 100602268(SETD1A) 100602353(SETD7) 100603309(SMYD2) 100603551(SMYD1) 100604245(KMT2A) 100607151(KMT2C) 100607333(PRDM7)
MCC: 695034(PRDM9) 697233(KMT2E) 698950(SMYD1) 700426(SETD7) 703402(SMYD3) 703717(SETD1B) 705511(KMT2A) 709375(SMYD2) 710795(KMT2D) 712416(SETD1A) 716753(KMT2C) 717778(ASH1L) 718835(KMT2B)
MCF: 101866311(KMT2A) 101867084(ASH1L) 101926094(KMT2E) 102115861(KMT2B) 102120149(SMYD3) 102120758(SMYD1) 102123137(SETD1B) 102123773(KMT2D) 102126119(PRDM7) 102128002(KMT2C) 102134166(SETD1A) 102136354(PRDM9) 102140141(SETD7) 102141885(SMYD2) 107128203
CSAB: 103215061(PRDM9) 103223879(ASH1L) 103226692(KMT2E) 103227268(KMT2C) 103230106(SMYD2) 103230910(SMYD3) 103231168(SETD1A) 103233507(PRDM7) 103234531(KMT2B) 103236281(SETD7) 103238253(KMT2D) 103239290(SETD1B) 103241358(SMYD1) 103248594(KMT2A)
RRO: 104654337(SETD7) 104659604(ASH1L) 104661596(SETD1A) 104665589(KMT2A) 104666361(SETD1B) 104667085(KMT2B) 104669844(SMYD2) 104674171(SMYD1) 104674292(PRDM7) 104675848(KMT2E) 104676513(SMYD3) 104677903 104678716(KMT2C) 104679726(KMT2D)
RBB: 108512323(KMT2B) 108515913 108518888(SMYD1) 108522758(SETD7) 108523124(KMT2C) 108523384(SETD1B) 108526582(SETD1A) 108526806(ASH1L) 108527467(SMYD2) 108528557(SMYD3) 108528969(PRDM7) 108531292(KMT2E) 108536375(KMT2A) 108543918(KMT2D)
CJC: 100388751(SMYD1) 100389921(KMT2E) 100391138(KMT2A) 100392519(SMYD3) 100393607(ASH1L) 100398610(SETD1B) 100399648(PRDM7) 100401397(KMT2C) 100404005(SMYD2) 100407541(KMT2B) 100408425(KMT2D) 100414241(SETD7) 100415635(SETD1A)
SBQ: 101029847(KMT2A) 101033099(KMT2E) 101034359(KMT2B) 101037539(KMT2D) 101039502(SMYD3) 101042903(SETD1A) 101043413(SMYD1) 101043552(KMT2C) 101045177(SETD1B) 101046051(ASH1L) 101047679(SETD7) 101048329 101049466 101050442(SMYD2)
MMU: 12180(Smyd1) 192195(Ash1l) 208043(Setd1b) 213389(Prdm9) 214162(Kmt2a) 226830(Smyd2) 231051(Kmt2c) 233904(Setd1a) 381022(Kmt2d) 69188(Kmt2e) 69726(Smyd3) 73251(Setd7) 75410(Kmt2b)
MCAL: 110290320(Smyd3) 110291461(Ash1l) 110291535(Setd7) 110294014(Kmt2e) 110295015(Setd1b) 110295273(Kmt2c) 110296132(Smyd1) 110297666(Kmt2b) 110298244(Setd1a) 110298532(Smyd2) 110301786(Kmt2a) 110310214(Kmt2d) 110312704
MPAH: 110312745(Setd1b) 110313856(Kmt2e) 110316198(Kmt2c) 110316349(Smyd1) 110317687(Setd1a) 110320364(Setd7) 110320636(Ash1l) 110321293(Smyd3) 110322084(Smyd2) 110327485(Kmt2a) 110334561(Kmt2d) 110338243 110338314(Kmt2b)
RNO: 100359816(Setd1b) 100362634(Kmt2d) 102550344(Kmt2b) 289372(Smyd2) 297333(Smyd1) 310638(Ash1l) 311968(Kmt2e) 315606(Kmt2a) 365155(Prdm9) 498295(Smyd3) 502710(Kmt2c) 689954(Setd7)
MUN: 110541941 110545142(Setd7) 110545334(Setd1b) 110547438(Kmt2d) 110548961(Ash1l) 110549115(Kmt2a) 110550986(Kmt2b) 110552814(Kmt2e) 110553406(Smyd2) 110557574(Smyd3) 110559772 110559774 110561122(Prdm9) 110562254(Smyd1) 110564205 110564208
CGE: 100750575(Kmt2b) 100752747(Prdm9) 100753294(Setd1b) 100753962(Setd1a) 100754103(Ash1l) 100756731(Kmt2e) 100760424(Kmt2a) 100761694(Smyd2) 100764840(Smyd3) 100765465(Kmt2d) 100766221(Smyd1) 100767175(Setd7) 100767367(Kmt2c)
NGI: 103726333(Setd1a) 103727065(Smyd2) 103729965(Kmt2b) 103732191(Kmt2e) 103737043(Smyd1) 103739104(Setd1b) 103742349(Prdm9) 103742371(Setd7) 103745326(Kmt2c) 103746872(Smyd3) 103748298(Kmt2a) 103750570(Kmt2d) 103750808(Ash1l)
HGL: 101698086 101698170(Kmt2c) 101699273(Kmt2b) 101701112 101702850(Setd1b) 101709197(Setd1a) 101712321(Kmt2e) 101715832(Setd7) 101716671(Kmt2a) 101718411(Kmt2d) 101718535(Smyd1) 101720447(Smyd2) 101722574(Smyd3) 101723836(Ash1l)
CCAN: 109674462 109675706(Smyd3) 109682842(Setd1a) 109684282(Kmt2e) 109685268(Kmt2c) 109686401(Setd1b) 109688014(Ash1l) 109689598(Kmt2b) 109689973(Kmt2a) 109691464(Setd7) 109694824(Kmt2d) 109695167 109700578(Smyd1) 109700718(Smyd2) 109702113 109702114
OCU: 100339782 100344249(SMYD2) 100347516(SMYD3) 100347618(SETD1B) 100347837(SETD7) 100353483(KMT2B) 100353688(KMT2C) 100353733(KMT2A) 100353840(KMT2E) 100354139(SETD1A) 100354541(ASH1L) 100355437(SMYD1) 100357052(KMT2D) 100358830(PRDM7) 100358832 103347079
TUP: 102469443(ASH1L) 102470517(SETD7) 102473382(KMT2A) 102474223(SETD1B) 102477772(KMT2B) 102478405(SETD1A) 102479012(KMT2C) 102480722(KMT2D) 102483069(KMT2E) 102483290(SMYD3) 102493552(SMYD1) 102496135(PRDM9) 102496151(SMYD2)
CFA: 100688666(KMT2B) 475758(SMYD1) 475895(KMT2E) 476079(SETD7) 479417(KMT2A) 480026(SMYD2) 480101(SMYD3) 480128(ASH1L) 486257(SETD1B) 486558(KMT2D) 489916(SETD1A) 611094(KMT2C)
VVP: 112916198(KMT2C) 112916807(SMYD1) 112918925(ASH1L) 112920160(KMT2A) 112921101(KMT2D) 112921783(SMYD2) 112923542(SMYD3) 112924552 112925373(KMT2E) 112928324(KMT2B) 112929256(SETD1A) 112934919(SETD7) 112935175(SETD1B)
AML: 100465228(KMT2C) 100466350(SMYD3) 100466490(SMYD2) 100468393(KMT2E) 100469094(KMT2B) 100469373(PRDM7) 100472168(SETD7) 100474237(ASH1L) 100478541(SETD1B) 100479447(KMT2D) 100482700(SETD1A) 100483766(SMYD1) 100484220(KMT2A) 109490334
UMR: 103657933(SETD1A) 103658074(SETD7) 103660985(KMT2C) 103661268(SETD1B) 103662507(KMT2A) 103666923(SMYD3) 103668369(ASH1L) 103671476(SMYD1) 103672523(SMYD2) 103673975(PRDM7) 103674714(KMT2E) 103675622(KMT2D) 103682560(KMT2B)
UAH: 113241427(KMT2C) 113242840(SMYD1) 113244759(KMT2B) 113245266(ASH1L) 113251646(PRDM7) 113255688(SETD7) 113257661(KMT2D) 113258804(KMT2E) 113259992(KMT2A) 113262691(SMYD2) 113262946(SMYD3) 113266937(SETD1B) 113267709(SETD1A)
ORO: 101362332(KMT2E) 101362407(SETD1B) 101362745(ASH1L) 101363392 101363669(KMT2A) 101364358(SMYD1) 101365628(KMT2C) 101368440(SETD7) 101369213(KMT2D) 101370290(KMT2B) 101371861(SMYD2) 101376995(SETD1A) 101383043(PRDM7) 101384991(SMYD3)
FCA: 101081435(SMYD2) 101084095(KMT2C) 101084945(KMT2E) 101085009(PRDM7) 101086114(ASH1L) 101089231(SMYD3) 101090288(KMT2A) 101091070(SETD1A) 101091191(SETD7) 101095247(SMYD1) 101095268(KMT2D) 101096419(SETD1B) 101098760(KMT2B)
PTG: 102949117(KMT2E) 102949463(SMYD3) 102953445(SETD7) 102956940(KMT2A) 102962859(KMT2D) 102964154(KMT2C) 102964982(KMT2B) 102968240(SMYD2) 102969005(SETD1A) 102969379(ASH1L) 102970032(SMYD1) 102970685(SETD1B) 102971819(PRDM7)
PPAD: 109245496(PRDM7) 109249058(KMT2D) 109249505(SETD7) 109251114(SMYD3) 109251503(KMT2B) 109252401(KMT2C) 109254457(SMYD2) 109256230(ASH1L) 109258968(SETD1A) 109264245(SMYD1) 109268101(KMT2E) 109277797(SETD1B) 109278556(KMT2A)
AJU: 106966460(KMT2A) 106966796(SMYD2) 106967594(SETD1B) 106968611(SMYD3) 106969329(KMT2D) 106974745(KMT2B) 106976180(SETD7) 106978140(SMYD1) 106978485(KMT2E) 106979084(SETD1A) 106981535(ASH1L) 106984461(KMT2C) 106985288(PRDM7)
BTA: 100139638 100190914(PRDM9) 100851938 506805(KMT2D) 508330(KMT2A) 514102(SETD1B) 515928(SETD7) 516002(PRDM7) 520584 537404(SMYD1) 539121(KMT2E) 540563(ASH1L) 615229(SMYD2) 616050(SMYD3) 782887(SETD1A) 785776(KMT2B) 789336(KMT2C)
BOM: 102267186(KMT2C) 102268887(KMT2D) 102269320(KMT2B) 102270977(SMYD1) 102271291 102273734(SMYD2) 102275046(ASH1L) 102279495(SETD1A) 102280025(KMT2A) 102280610(SETD1B) 102281278(KMT2E) 102281809(SETD7) 102282730 102287417(SMYD3)
BIU: 109553548(ASH1L) 109554959 109554963 109557366(KMT2E) 109558041(KMT2C) 109559148(KMT2D) 109561910 109566148(SMYD1) 109569413(KMT2A) 109570555(SMYD3) 109570591(SMYD2) 109570912(SETD1B) 109571070(SETD7) 109572325(KMT2B) 109578511(SETD1A)
BBUB: 102392548(SMYD3) 102393219(SETD1B) 102394548(SETD7) 102396938(KMT2C) 102398212(KMT2E) 102400596(KMT2B) 102401126(KMT2A) 102401677(SETD1A) 102401706(KMT2D) 102403578 102406655 102408066(SMYD1) 102413004 102415367(ASH1L) 102416088(SMYD2) 112582202 112582680 112582838
CHX: 102168698(KMT2D) 102169033(KMT2A) 102169548(KMT2E) 102170478(SETD1A) 102171177(SMYD3) 102172292(KMT2B) 102177044(PRDM9) 102179971(SETD1B) 102181925(KMT2C) 102183791(PRDM9) 102185413(ASH1L) 102185508 102187140(SMYD1) 102189783(SMYD2) 102191824(SETD7)
OAS: 101101875 101101916(KMT2A) 101102409(SMYD2) 101103509(SETD1B) 101103705 101104086(KMT2B) 101105467(SETD1A) 101108731(SMYD1) 101115617(KMT2C) 101115990(SETD7) 101116161(SMYD3) 101118592 101119775(ASH1L) 101120741(KMT2D) 101120895 101121766(KMT2E) 114116628
SSC: 100155920(ASH1L) 100156137(SETD1B) 100294702(SMYD1) 100294706(SMYD2) 100294707(SMYD3) 100511747(SETD1A) 100514805(KMT2C) 100520742(KMT2B) 100620538(PRDM7) 100623006(KMT2A) 100626704(SETD7) 100628131(KMT2E) 110260656(KMT2D)
CFR: 102506865(SETD7) 102507730(KMT2C) 102509980(SETD1A) 102510314(PRDM7) 102510601(ASH1L) 102513005(SMYD1) 102514543(KMT2E) 102514741(SMYD3) 102515223(KMT2D) 102515785(SMYD2) 102517824(KMT2A) 102520520(KMT2B) 102521372(SETD1B) 102523091 106728486
CDK: 105087090(SETD7) 105088051 105088782(ASH1L) 105090168(KMT2A) 105093021(KMT2E) 105098689(KMT2C) 105099293(SMYD2) 105099491(SMYD3) 105102557(SETD1B) 105102789(SETD1A) 105103813(KMT2D) 105104177(SMYD1) 105106131(PRDM7) 116154616
BACU: 103002011(KMT2E) 103002269(SETD7) 103004413(KMT2D) 103004433(KMT2C) 103008957(SETD1A) 103010622(SETD1B) 103014183(KMT2A) 103015601(KMT2B) 103015822(ASH1L) 103018045(SMYD3) 103018379(SMYD1) 103018911(PRDM7) 103020103(SMYD2)
LVE: 103068531(KMT2A) 103070332(SMYD1) 103071598(SETD7) 103073652(KMT2B) 103074842(KMT2E) 103077679(SETD1B) 103078348(KMT2C) 103079757(SETD1A) 103081140(SMYD3) 103082116(KMT2D) 103083457(PRDM7) 103084369 103087473(ASH1L) 103090372(SMYD2)
OOR: 101269640(KMT2D) 101271862(SMYD2) 101276223(KMT2B) 101278571(KMT2A) 101278914(SETD1B) 101281657(SMYD3) 101282114(SETD7) 101283071(SETD1A) 101284649(SMYD1) 101285642(KMT2E) 101288516(KMT2C) 101288541(ASH1L) 101290159(PRDM7)
DLE: 111164613(KMT2E) 111165396(SMYD1) 111166868(KMT2A) 111167169(ASH1L) 111174034(KMT2D) 111176572(KMT2C) 111177545(SMYD3) 111179118(SETD7) 111179685(PRDM7) 111181136(KMT2B) 111182119(SETD1A) 111184680(SMYD2) 111186875(SETD1B)
PCAD: 102974760(PRDM7) 102977910(SETD1B) 102980726(KMT2E) 102980789(SMYD1) 102981445(KMT2A) 102981848(KMT2D) 102986025(SETD7) 102987727(KMT2B) 102988929(KMT2C) 102989011(SMYD3) 102992344(SMYD2) 102992941(SETD1A) 102993773(ASH1L) 112064829 114487551
ECB: 100052774(SMYD2) 100052805(SMYD1) 100053168(PRDM7) 100057386(ASH1L) 100058928(KMT2E) 100058932(KMT2D) 100059267(SMYD3) 100059802(KMT2B) 100063257(SETD7) 100063523(SETD1A) 100064812(KMT2C) 100071238(KMT2A) 100146430(SETD1B)
EPZ: 103541678(SETD1B) 103545551 103546689(KMT2A) 103547270(SETD1A) 103547761(SMYD2) 103548807 103549975(SMYD1) 103551020(SETD7) 103552202(KMT2D) 103552840 103553137(KMT2C) 103560579(KMT2E) 103562021 103566091(KMT2B) 103566688 103567807(PRDM7)
EAI: 106823334(KMT2C) 106825187(KMT2E) 106828486(ASH1L) 106829152(KMT2B) 106831838(SETD1A) 106836860(KMT2D) 106838574(SMYD1) 106838612(SETD7) 106840333(KMT2A) 106842219(SETD1B) 106846818(SMYD2) 106846844(SMYD3)
MYB: 102240554 102244915(SMYD2) 102244965(KMT2D) 102246410(KMT2E) 102246482(SETD7) 102246704(KMT2C) 102246785(KMT2A) 102247786(SMYD3) 102253255(SETD1A) 102255512(SETD1B) 102255643 102256394(ASH1L) 102257900 102258373 102259087(KMT2B) 102262117
MYD: 102751347(SETD1B) 102755932(SMYD1) 102756071(SETD1A) 102758785(KMT2E) 102759674(KMT2C) 102760166(SETD7) 102760582(SMYD2) 102762410(KMT2D) 102764796(ASH1L) 102765569 102766910(KMT2A) 102769466(SMYD3) 102771251(KMT2B) 102774259 107182758
MNA: 107524895(KMT2C) 107524924 107528109(KMT2D) 107528337(SMYD3) 107528646(SMYD1) 107530776 107530799 107534917(SETD7) 107539362 107540799(SETD1A) 107541833(SETD1B) 107542284(KMT2E) 107542826 107543372(KMT2B) 107543779(ASH1L) 107546243(SMYD2)
HAI: 109371387 109372008(KMT2B) 109374193(SETD1A) 109376837(SMYD1) 109378226 109378400 109378707 109378765 109379108(SMYD2) 109381405(PRDM7) 109385301(KMT2A) 109386061(SETD1B) 109389650(KMT2C) 109391450 109392049(KMT2E) 109393224(KMT2D) 109393386(ASH1L) 109394201(SETD7)
DRO: 112296748(PRDM7) 112297714(SMYD2) 112301980 112303106(SMYD1) 112303206(KMT2E) 112303918 112303963 112304818(SETD1A) 112308262(KMT2C) 112310608(SETD1B) 112312687(SETD7) 112313830 112314381(KMT2A) 112316652 112316914(ASH1L) 112318232(KMT2D) 112318753(SMYD3) 112320053(KMT2B)
PALE: 102878419(PRDM7) 102879153(SETD1B) 102880671(SMYD1) 102881431(KMT2B) 102883630(SMYD2) 102884674(SETD1A) 102887843(SMYD3) 102888124(ASH1L) 102888384(KMT2E) 102888593(KMT2D) 102889824(PRDM9) 102890289(SETD7) 102893336(KMT2A) 102897550(KMT2C)
RAY: 107497624(KMT2B) 107498661(SMYD3) 107502258(KMT2A) 107503985(SETD1A) 107505913(SMYD1) 107508545 107511501(KMT2E) 107514237(KMT2D) 107515234(SETD1B) 107515339(SETD7) 107516247(PRDM9) 107520298(KMT2C) 107521457(ASH1L) 107521612 107521638(SMYD2)
LAV: 100653681(KMT2A) 100653839(SETD7) 100659534(SMYD3) 100660034(PRDM7) 100662609(SETD1A) 100664734 100666322(PRDM9) 100668468(ASH1L) 100668488(SETD1B) 100669611(KMT2B) 100670013(KMT2D) 100671071(KMT2E) 100672564(SMYD1) 100673765(KMT2C) 100674556(SMYD2) 100676686
MDO: 100013387(SETD1A) 100017118(ASH1L) 100018480(KMT2E) 100019161(KMT2C) 100023305(SMYD2) 100027436(SETD7) 100029674(SMYD1) 100031440(KMT2A) 100617561(KMT2B) 100618514(SETD1B) 100619798(SMYD3) 103099827(KMT2D)
SHR: 100916165(SMYD1) 100920575(KMT2C) 100922144(KMT2E) 100923245 100924557(KMT2A) 100927672(KMT2B) 100928096(SETD1B) 100928575(KMT2D) 100929261(SETD7) 100929291(SETD1A) 100931585(ASH1L) 100932883(SMYD3) 100934440(SMYD2)
PCW: 110194047(KMT2D) 110194897(SETD7) 110196348(SMYD1) 110196787(SETD1B) 110201341(KMT2B) 110201406(PRDM9) 110205493(SMYD3) 110206991(KMT2E) 110207193(KMT2A) 110211945(ASH1L) 110222694(SMYD2) 110223143(SETD1A) 110223876(KMT2C)
OAA: 100074286(KMT2C) 100074411(SETD1B) 100077208(KMT2E) 100078649(SMYD1) 100079176(SMYD2) 100081674(SETD7) 100082753(SMYD3) 100086068(KMT2A) 100090957(SETD1A) 103165316(KMT2B) 103168045(ASH1L)
GGA: 373960(SMYD1) 414897(KMT2A) 416851(SETD1B) 417712(KMT2E) 420437(KMT2C) 421361(SMYD2) 421489(SMYD3) 422443(SETD7) 425064(ASH1L) 425846(KMT2D)
MGP: 100538978(SMYD2) 100539732(ASH1L) 100540662(KMT2A) 100541967(SETD7) 100544670(SETD1B) 100545169(KMT2C) 100545555(KMT2E) 100548953(SMYD1) 104909329 104915798
CJO: 107308762(KMT2C) 107311083(SMYD2) 107311243(SMYD3) 107313101(SETD7) 107314020(SMYD1) 107321274(SETD1B) 107324133(KMT2A) 107324503(ASH1L) 107325180(KMT2E) 107325738(KMT2D)
NMEL: 110387546(KMT2A) 110387902(ASH1L) 110389135(KMT2D) 110392363(KMT2E) 110393789(KMT2C) 110395863(SMYD3) 110396134(SMYD2) 110397503(SETD7) 110398544(SMYD1) 110406578(SETD1B)
APLA: 101790791(SMYD2) 101796266(KMT2C) 101797321(KMT2A) 101800254(SETD7) 101800831(SMYD1) 101801343(SMYD3) 101803072(SETD1B) 101805084(KMT2E)
ACYG: 106031413(SETD1B) 106031578(SMYD2) 106033933(SMYD1) 106039772(KMT2A) 106040965(SETD7) 106043274(KMT2E) 106046952(KMT2C) 106047718(KMT2D) 106048498(ASH1L) 106049693(SMYD3)
TGU: 100219723(SMYD3) 100219994(SETD7) 100225647(SETD1B) 100226399(KMT2E) 100226907(KMT2D) 100227193(KMT2C) 100229714(ASH1L) 100230154(SMYD1) 100230503(SMYD2) 100231049(KMT2A)
LSR: 110468513(SETD7) 110470458(KMT2A) 110471483(ASH1L) 110471750(SETD1B) 110472726(KMT2E) 110473308(SMYD1) 110479948(SMYD2) 110480395(KMT2D) 110481707(SMYD3) 110484559(KMT2C)
SCAN: 103813061(KMT2C) 103813524(KMT2E) 103817699(SMYD3) 103818319(SETD1B) 103821549(SMYD2) 103822533(SETD7) 103822784(KMT2A) 103823501(SMYD1) 103823951(ASH1L) 103824625(KMT2D)
GFR: 102031396(KMT2C) 102032923(SMYD2) 102034037(KMT2D) 102036439(KMT2A) 102037071(SMYD1) 102037758(SMYD3) 102040049(SETD1B) 102040515(SETD7) 102042927(ASH1L) 102045471(KMT2E) 106632190
FAB: 101806346(KMT2C) 101807006(SMYD2) 101807375(SETD7) 101812652(SETD1B) 101812878(KMT2E) 101813917(KMT2A) 101818086(KMT2D) 101819907(ASH1L) 101821319(SMYD3) 101822247(SMYD1)
PHI: 102099277(KMT2C) 102100454(KMT2D) 102101401(SMYD2) 102102416(SMYD1) 102103515(KMT2A) 102106186(SETD7) 102107307(SMYD3) 102108338(KMT2E) 102113028(ASH1L) 102114734(SETD1B) 106628993
PMAJ: 107198594(KMT2D) 107202071(SMYD2) 107202430(SMYD3) 107203381(SETD7) 107203527(SMYD1) 107204272(KMT2E) 107211664(SETD1B) 107214385(KMT2A) 107214568(ASH1L) 107216349(KMT2C)
CCAE: 111923252(KMT2E) 111925501(KMT2C) 111926193(SMYD2) 111926986 111927591 111928311(SMYD1) 111928908(SETD7) 111936709(SETD1B) 111939213(KMT2A) 111939443(ASH1L) 111940566
CCW: 104683547(ASH1L) 104684478(SMYD3) 104685633(SMYD2) 104686428(KMT2C) 104686872(KMT2E) 104688830(SETD1B) 104690813(SMYD1) 104692048(KMT2A) 104697344(SETD7)
ETL: 114055005(SETD1B) 114056306(KMT2A) 114058383(SETD7) 114060528(KMT2E) 114060897(SMYD2) 114062389(KMT2C) 114065339(SMYD3) 114066019 114067206(SMYD1) 114069574(ASH1L) 114071069(KMT2D) 114072229 114073002
FPG: 101911864(SETD1B) 101913546(ASH1L) 101916525(KMT2D) 101917176(KMT2C) 101917301(SETD7) 101919056(SMYD1) 101919125(SMYD3) 101919912(KMT2E) 101922729(KMT2A) 101923412(SMYD2)
FCH: 102047191(KMT2C) 102047542(KMT2E) 102049111 102051296(SETD1B) 102053523(SETD7) 102056587(ASH1L) 102057033(SMYD1) 102057924(SMYD2) 102058880(SMYD3) 102059401(KMT2A)
CLV: 102083945(SETD1B) 102084453(KMT2A) 102086496(SMYD1) 102087865(SETD7) 102088613(SMYD2) 102088903(KMT2E) 102090928(ASH1L) 102091442(KMT2D) 102092665(SMYD3) 102097963(KMT2C)
EGZ: 104122745(SETD1B) 104123317 104126982(SMYD1) 104128583(KMT2E) 104130998(KMT2C) 104131533(SMYD3) 104132856(SMYD2) 104134673(SETD7) 104134854(ASH1L) 104135262 104135361(KMT2A)
NNI: 104010731(KMT2E) 104011458(SMYD3) 104014894(KMT2C) 104015980(SETD7) 104016208(KMT2A) 104017938 104018532(SMYD1) 104019711(SMYD2) 104020487(ASH1L) 104020788(SETD1B)
ACUN: 113477175(KMT2C) 113477910(SMYD3) 113478725(SMYD2) 113479169(SMYD1) 113479515(SETD7) 113485968(SETD1B) 113488577(KMT2A) 113488743(ASH1L) 113490163(KMT2E)
PADL: 103913294(ASH1L) 103914561(SETD1B) 103914598(SMYD3) 103915639(KMT2C) 103916551(KMT2A) 103920580(KMT2E) 103920974(SETD7) 103922130(SMYD2) 103923505(SMYD1)
AAM: 106484901(SMYD1) 106485191(KMT2A) 106485306(KMT2C) 106485538(SMYD3) 106485892(KMT2E) 106490428(SMYD2) 106491857(SETD7) 106494341(ASH1L) 106495668(SETD1B) 106497500(KMT2D)
ASN: 102368053(SMYD1) 102372997(ASH1L) 102373099(KMT2D) 102374512(SETD7) 102375642(KMT2E) 102378568(SETD1B) 102379342(KMT2C) 102381556(SMYD3) 102382195(KMT2B) 102383161(SMYD2) 102385246(KMT2A) 102387237(SETD1A)
AMJ: 102560006(KMT2D) 102560388(KMT2E) 102567474(KMT2C) 102568755(SETD7) 102571713(ASH1L) 102571979 102572253(KMT2A) 102574091(SETD1B) 102575326(SMYD2) 102575695(SMYD1) 102576362(SMYD3) 102576444(SETD1A) 106739435 109281961
PSS: 102445204 102446823 102448089(SETD1B) 102448117(ASH1L) 102449156(SMYD1) 102450509(KMT2D) 102454598(KMT2E) 102455968 102456582(SMYD3) 102459016(KMT2C) 102460627 102460633(SETD1A) 102461265(SMYD2) 102461649(SETD7) 102463628(KMT2A)
CMY: 102931937(KMT2B) 102932627 102933355(KMT2E) 102933435(SMYD2) 102934693(SETD1B) 102936055(SMYD1) 102937004(SETD1A) 102937036(SMYD3) 102941272(KMT2A) 102943205(SETD7) 102943662(ASH1L) 102944171 102948345(KMT2C)
CPIC: 101930966(SETD7) 101934288(KMT2D) 101934563 101935009(KMT2E) 101936901(SETD1A) 101939661(SETD1B) 101939705 101941687(KMT2A) 101942050(ASH1L) 101947848 101948178(SMYD2) 101950574(KMT2B) 101951595(SMYD1) 101951981(SMYD3) 101953918(KMT2C)
ACS: 100551939(setd7) 100553183(kmt2e) 100554175(kmt2d) 100556055(kmt2c) 100556600(kmt2b) 100557667(smyd2) 100560745(kmt2a) 100561699(smyd1) 100563888(ash1l) 103279564(setd1a) 103279992 103280931(setd1b) 107982259
PVT: 110071916(KMT2C) 110073660(SETD7) 110075080(KMT2D) 110076069(SMYD3) 110079453(KMT2A) 110080953(KMT2E) 110081037(ASH1L) 110083882(SETD1B) 110086348(SMYD1) 110086418(SETD1A) 110086747 110087176(SMYD2) 110089900(KMT2B)
PBI: 103049419 103051289(KMT2D) 103051962(KMT2E) 103052345(SMYD3) 103054198(SMYD2) 103054534(SETD1A) 103055134(PRDM9) 103056555(SETD7) 103058624(SMYD1) 103058696(KMT2B) 103060233(ASH1L) 103063162(SETD1B) 103065683 103067762(KMT2A)
PMUR: 107284778(KMT2A) 107286389(KMT2D) 107286731 107286738 107286983(SETD1B) 107287999(KMT2B) 107289289(SMYD2) 107289708 107290222(SETD1A) 107292628 107293153(SETD7) 107297020(ASH1L) 107298635(KMT2E) 107301328 107302384(SMYD1) 107303312(KMT2C)
PMUA: 114582254(SMYD1) 114582823(SETD1A) 114585722(KMT2A) 114586200(SETD1B) 114586229(ASH1L) 114587663 114594456(SMYD3) 114594675(SMYD2) 114603572(KMT2B) 114604135(SETD7) 114605818(KMT2E) 114607001(KMT2C)
GJA: 107105569(SMYD1) 107105838(KMT2D) 107106655(SETD1A) 107106688 107108065(SMYD3) 107108169(KMT2B) 107109138 107110772(SETD7) 107112539(KMT2A) 107113725(KMT2E) 107115893(SETD1B) 107119617(ASH1L) 107121665(SMYD2) 107123156 107123162(KMT2C)
XTR: 100135006(kmt2a) 100144721(kmt2b) 100145429(smyd1) 100486829(kmt2c) 100487270(setd1a) 100494109(kmt2d) 100494527(smyd3) 100495522(smyd2) 613102(setd7) 779539(kmt2e) 780106(setd1b)
NPR: 108783805(SMYD2) 108784343(KMT2C) 108787262(SETD1B) 108787486(SMYD3) 108787523(SETD7) 108791395(KMT2D) 108794233(ASH1L) 108794984(KMT2A) 108795231(KMT2E) 108796886(SMYD1) 108799776(KMT2B) 108800988(SETD1A)
DRE: 100536523(kmt2d) 321245(smyd1a) 325395(kmt2e) 393876(prdm9) 436729(setd7) 541423(smyd2a) 556535(setd1a) 557048(kmt2a) 560793(kmt2ca) 560856(kmt2ba) 563799(ash1l) 566825(kmt2bb) 567970(setd1ba) 568616(smyd2b) 569027(smyd1b) 569507(smyd3) 571274(setd1bb)
NFU: 107372442(kmt2b) 107373342(setd1b) 107374212 107375014(smyd1) 107377597(smyd2) 107378515(setd1a) 107379592(ash1l) 107380358(kmt2a) 107381186 107381206(smyd3) 107383945(kmt2c) 107386366(kmt2e) 107387053(setd7) 107387683(znf286a) 107390885(kmt2d) 107393824 107393825 107394125 107394561 107394636
LCM: 102347272(KMT2C) 102349685(SMYD1) 102349988(KMT2E) 102350182(SETD7) 102351078(SETD1A) 102354014(KMT2D) 102354331 102354519(SMYD2) 102354605 102357046(KMT2A) 102357625 102361515(SMYD3) 102363172(SETD1B) 102367246(ASH1L)
CMK: 103172000 103176975(kmt2e) 103180354(kmt2a) 103181297(setd7) 103181513(smyd1) 103181738(smyd3) 103184390(setd1b) 103186165(smyd2) 103189259(kmt2d) 103189435(kmt2c) 103189436 103191129
DME: Dmel_CG13761(Smyd3) Dmel_CG3848(trr) Dmel_CG40351(Set1) Dmel_CG8651(trx) Dmel_CG8887(ash1)
DSI: Dsimw501_GD11928(Dsim_GD11928) Dsimw501_GD12268(Dsim_GD12268) Dsimw501_GD16408(Dsim_GD16408) Dsimw501_GD20433(Dsim_GD20433) Dsimw501_GD28104(Dsim_GD28104) Dsimw501_GD29063(Dsim_GD29063)
CEL: CELE_C26E6.9(set-2) CELE_R06F6.4(set-14) CELE_T12D8.1(set-16) CELE_T12F5.4(lin-59) CELE_T22A3.4(set-18) CELE_ZC8.3(set-30)
CBR: CBG03016(Cbr-set-14) CBG12017(Cbr-lin-59) CBG14580(Cbr-set-30) CBG18244(Cbr-set-16) CBG24752(Cbr-set-18)
ATH: AT1G43245 AT2G17900(SDG37) AT2G19640(ASHR2) AT4G15180(SDG2) AT5G06620(SDG38)
LJA: Lj0g3v0111689.1(Lj0g3v0111689.1) Lj0g3v0111689.2(Lj0g3v0111689.2) Lj0g3v0252639.1(Lj0g3v0252639.1) Lj0g3v0252639.2(Lj0g3v0252639.2) Lj0g3v0308279.1(Lj0g3v0308279.1) Lj0g3v0308279.2(Lj0g3v0308279.2) Lj0g3v0308279.3(Lj0g3v0308279.3) Lj1g3v0764540.1(Lj1g3v0764540.1) Lj1g3v0764540.2(Lj1g3v0764540.2) Lj2g3v2985910.1(Lj2g3v2985910.1) Lj2g3v2985910.2(Lj2g3v2985910.2) Lj2g3v2985910.3(Lj2g3v2985910.3) Lj3g3v2888370.1(Lj3g3v2888370.1) Lj3g3v2888370.2(Lj3g3v2888370.2) Lj4g3v0165060.1(Lj4g3v0165060.1) Lj4g3v0166140.1(Lj4g3v0166140.1)
DOSA: Os03t0704200-01(Os03g0704200) Os04t0423600-01(Os04g0423600) Os08t0180100-01(Os08g0180100) Os08t0205300-01(Os08g0205300) Os10t0410700-01(Os10g0410700)
ATS: 109736528(LOC109736528) 109741969(LOC109741969) 109747984(LOC109747984) 109776439(LOC109776439) 109778416(LOC109778416)
OLU: OSTLU_15174(SDG3512) OSTLU_32372(SDG3514) OSTLU_88595(SDG3527) OSTLU_92854(SDG3513)
SCE: YHR119W(SET1)
KMX: KLMA_30450(SET6) KLMA_60252(SET1)
NCS: NCAS_0B07030(NCAS0B07030) NCAS_0C01270(NCAS0C01270)
NDI: NDAI_0B04360(NDAI0B04360) NDAI_0K01280(NDAI0K01280)
TPF: TPHA_0I01480(TPHA0I01480)
TBL: TBLA_0C05500(TBLA0C05500)
TDL: TDEL_0A06370(TDEL0A06370) TDEL_0B05100(TDEL0B05100)
KAF: KAFR_0F00700(KAFR0F00700) KAFR_0H02340(KAFR0H02340)
SLB: AWJ20_424(SET6) AWJ20_608(SET1)
NCR: NCU01206(set-1) NCU01932(set-3) NCU02962
NTE: NEUTE1DRAFT125465(NEUTE1DRAFT_125465) NEUTE1DRAFT144212(NEUTE1DRAFT_144212) NEUTE1DRAFT150707(NEUTE1DRAFT_150707)
NHE: NECHADRAFT_123121(SDG2103) NECHADRAFT_49470(SDG2101) NECHADRAFT_74600(SDG2107)
ANG: ANI_1_1490164(An18g06840) ANI_1_1754144(An16g04950) ANI_1_2518094(An11g09860)
PBN: PADG_03985 PADG_06078 PADG_11427(PADG_02444)
SPO: SPBP8B7.07c(set6) SPCC306.04c(set1)
CNE: CND03610
CNB: CNBD2720
ABP: AGABI1DRAFT102088(AGABI1DRAFT_102088) AGABI1DRAFT120631(AGABI1DRAFT_120631) AGABI1DRAFT41599(AGABI1DRAFT_41599) AGABI1DRAFT76762(AGABI1DRAFT_76762)
ABV: AGABI2DRAFT120820(AGABI2DRAFT_120820) AGABI2DRAFT209673(AGABI2DRAFT_209673) AGABI2DRAFT211045(AGABI2DRAFT_211045) AGABI2DRAFT223832(AGABI2DRAFT_223832)
EHI: EHI_092690(175.t00011)
PYO: PY17X_1133200(PY04885)
PCB: PCHAS_113130(PC000913.02.0)
CPV: cgd7_5090
SMIN: v1.2.013565.t1(symbB.v1.2.013565.t1) v1.2.019699.t1(symbB.v1.2.019699.t1) v1.2.029529.t3(symbB.v1.2.029529.t3) v1.2.035053.t1(symbB.v1.2.035053.t1)
 » show all
Taxonomy
Reference
1  [PMID:12453419]
  Authors
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E
  Title
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
  Journal
Mol Cell 10:1119-28 (2002)
  Sequence
[hsa:4297]
Reference
2  [PMID:12540855]
  Authors
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ
  Title
Structure and catalytic mechanism of the human histone methyltransferase SET7/9.
  Journal
Nature 421:652-6 (2003)
DOI:10.1038/nature01378
  Sequence
[hsa:80854]
Reference
3  [PMID:15235609]
  Authors
Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y
  Title
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
  Journal
Nat Cell Biol 6:731-40 (2004)
DOI:10.1038/ncb1151
  Sequence
[hsa:64754]
Reference
4  [PMID:27129774]
  Authors
Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M
  Title
PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.
  Journal
J Biol Chem 291:13509-19 (2016)
  Sequence
[hsa:11105]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.354
IUBMB Enzyme Nomenclature: 2.1.1.354
ExPASy - ENZYME nomenclature database: 2.1.1.354
BRENDA, the Enzyme Database: 2.1.1.354

KEGG   ENZYME: 2.1.1.355Help
Entry
EC 2.1.1.355                Enzyme                                 

Name
[histone H3]-lysine9 N-trimethyltransferase;
KMT1A (gene name);
KMT1B (gene name);
KMT1C (gene name);
KMT1D (gene name);
KMT1E (gene name);
KMT1F (gene name);
MT8 (gene name);
SUV39H1 (gene name);
G9A (gene name);
EHMT1 (gene name);
PRDM2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
History
EC 2.1.1.355 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.355
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT
K11421  [histone H3]-lysine9 N-trimethyltransferase SETDB1
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2
Genes
HSA: 10919(EHMT2) 6839(SUV39H1) 7799(PRDM2) 79723(SUV39H2) 79813(EHMT1) 83852(SETDB2) 9869(SETDB1)
PTR: 107971148(SUV39H1) 452719(SETDB2) 462572(EHMT2) 464891(EHMT1) 466014(SUV39H2) 469125(PRDM2) 469481(SETDB1)
PPS: 100968253(EHMT1) 100972839(SETDB1) 100977497(SUV39H1) 100982469(SUV39H2) 100986951(SETDB2) 100991724(EHMT2) 103782930(PRDM2)
GGO: 101125370(PRDM2) 101126338(SUV39H2) 101139808(EHMT2) 101141713(SETDB2) 101146215(SETDB1) 101146540(SUV39H1) 101151843(EHMT1)
PON: 100172621(SUV39H1) 100431310(SETDB1) 100436926(SUV39H2) 100436958(PRDM2) 100437576(SETDB2) 100449422(EHMT1) 100460372(EHMT2)
NLE: 100581330(SETDB1) 100582767(PRDM2) 100584465(EHMT1) 100591032(SUV39H2) 100593118 100598636(SUV39H1) 100606578(EHMT2) 115834394
MCC: 697378(SUV39H2) 706277(SETDB2) 711040(SUV39H1) 715824(EHMT2) 716141(SETDB1) 716295(PRDM2) 721470(EHMT1)
MCF: 101926557(PRDM2) 102117410(SETDB1) 102124788(SETDB2) 102125769(EHMT1) 102134179(SUV39H1) 102136014(SUV39H2) 102139754(EHMT2)
CSAB: 103214423(SETDB2) 103221737(EHMT2) 103225565(PRDM2) 103231938(SUV39H1) 103237926(SUV39H2) 103239544(EHMT1) 103241360 103247223(SETDB1)
RRO: 104660660(SUV39H1) 104662745(SETDB2) 104664471(SUV39H2) 104669606(EHMT1) 104674046(PRDM2) 104678126(EHMT2) 104681064(SETDB1)
RBB: 108517467(SUV39H1) 108519969 108520267(EHMT2) 108530731(SETDB2) 108531071(SUV39H2) 108533259(SETDB1) 108542880(EHMT1)
CJC: 100385110(PRDM2) 100394788(SETDB2) 100398057(EHMT1) 100401369(SUV39H1) 100401513(SUV39H2) 100408867(EHMT2) 100411734(SETDB1)
SBQ: 101040475(SUV39H2) 101042658(SETDB1) 101043411(SETDB2) 101046305(EHMT2) 101052197(SUV39H1) 101054202(PRDM2) 101054241(EHMT1)
MMU: 107303348(Gm45935) 110147(Ehmt2) 110593(Prdm2) 20937(Suv39h1) 239122(Setdb2) 64707(Suv39h2) 77683(Ehmt1) 84505(Setdb1)
MCAL: 110284133(Ehmt2) 110287176(Suv39h1) 110289296(Suv39h2) 110291522(Setdb1) 110293588(Prdm2) 110309030(Setdb2) 110312405(Ehmt1)
MPAH: 110313347(Suv39h1) 110317691(Ehmt1) 110320737(Setdb1) 110322886(Prdm2) 110325326(Setdb2) 110333642(Suv39h2) 110335935(Ehmt2)
RNO: 100361710(Setdb2) 302553(Suv39h1) 313678(Prdm2) 361798(Ehmt2) 362078(Ehmt1) 364785(Suv39h2) 689883(Setdb1)
MUN: 110540015(Setdb2) 110544320 110554698(Suv39h2) 110556467(Prdm2) 110560108(Ehmt2) 110560774(Setdb1) 110561991(Suv39h1) 110565135 110565136 110565639(Ehmt1)
CGE: 100754544(Ehmt1) 100755145(Suv39h2) 100764568(Suv39h1) 100765697(Setdb1) 100769417(Ehmt2) 100773277(Prdm2) 100774155 107979496
NGI: 103724422(Ehmt2) 103727170(Setdb2) 103730089(Setdb1) 103732609(Ehmt1) 103735184(Suv39h2) 103741644(Suv39h1) 103749132 103752332(Prdm2)
HGL: 101696702(Setdb2) 101697232(Ehmt2) 101699104(Ehmt1) 101699822(Prdm2) 101701917(Suv39h2) 101706867(Suv39h1) 101715248(Setdb1)
CCAN: 109681205(Setdb1) 109688969(Ehmt1) 109689573(Ehmt2) 109691104(Setdb2) 109691500(Suv39h2) 109701207(Suv39h1) 109702677(Prdm2)
OCU: 100342335(PHF11) 100348361(EHMT1) 100354725(SUV39H1) 100355131(EHMT2) 100355877(SETDB1) 100358024(SUV39H2) 103352508(PRDM2)
TUP: 102468719(SUV39H1) 102472765 102479735(EHMT2) 102495109(SUV39H2) 102498729(EHMT1) 102499550(PRDM2) 102502264(SETDB1) 102503290(SETDB2)
CFA: 100688431(PRDM2) 474851(EHMT2) 477995(SUV39H2) 483186(SETDB1) 485441(SETDB2) 491224(EHMT1) 491868(SUV39H1)
VVP: 112907242(SUV39H1) 112907769(SETDB1) 112911417(EHMT1) 112913622(EHMT2) 112929764(PRDM2) 112933120(SUV39H2) 112933943(SETDB2)
AML: 100466861(EHMT1) 100468794(EHMT2) 100469547(SUV39H2) 100472595(SUV39H1) 100476962(SETDB2) 100481446(PRDM2) 100482250(SETDB1)
UMR: 103664189(SUV39H2) 103666633(PRDM2) 103667532(SETDB1) 103669105(SUV39H1) 103675323(EHMT1) 103677615(SETDB2) 103682289(EHMT2)
UAH: 113241391(SUV39H2) 113243735(EHMT2) 113246155(SETDB1) 113248390 113248430 113251315 113265922(SUV39H1) 113270485(PRDM2)
ORO: 101364966(PRDM2) 101372094(SETDB1) 101374258(SUV39H2) 101375740(EHMT1) 101376988(EHMT2) 101381146(SUV39H1) 101381937(SETDB2)
FCA: 101082169(PRDM2) 101083571(SUV39H1) 101087111(EHMT1) 101091940(EHMT2) 101094118(SETDB1) 101099218(SUV39H2)
PTG: 102950897(SUV39H1) 102954489(EHMT1) 102962904(SETDB2) 102963752(SUV39H2) 102967892(PRDM2) 102968259(EHMT2) 102970727(SETDB1)
PPAD: 109248069(SUV39H1) 109257028(SETDB1) 109260239(EHMT1) 109260503(EHMT2) 109265964 109273698(SUV39H2) 109274376(PRDM2)
AJU: 106970864(SUV39H1) 106971016(SUV39H2) 106972687 106979835(SETDB1) 106983481(EHMT2) 106988167(PRDM2) 106989056(EHMT1)
BTA: 100138100(SETDB1) 509382(SETDB2) 514062(EHMT2) 523047(SUV39H1) 528606(EHMT1) 536936(SUV39H2) 789222(PRDM2)
BOM: 102264756(SUV39H2) 102271111(EHMT1) 102271191(SUV39H1) 102279999(EHMT2) 102281203(PRDM2) 102287560(SETDB2) 102288279(SETDB1)
BIU: 109555305(SETDB1) 109565691(EHMT1) 109566720(SETDB2) 109567973(SUV39H2) 109570372(PRDM2) 109576929(EHMT2)
BBUB: 102392662(SETDB2) 102395323(EHMT1) 102396138(PRDM2) 102401546(SUV39H1) 102405188(EHMT2) 102408652(SETDB1) 102415169(SUV39H2)
CHX: 102171636(PRDM2) 102174919(SUV39H1) 102176621(SUV39H2) 102178316(EHMT2) 102180982(SETDB1) 102186776(SETDB2) 102189411(EHMT1)
OAS: 101109230(SETDB1) 101110031(SUV39H1) 101115739(EHMT2) 101116064(SETDB2) 101116417(SUV39H2) 101123545(EHMT1) 105601941(PRDM2)
SSC: 100124382(EHMT2) 100157885(SETDB2) 100157920(SETDB1) 100518559(PRDM2) 110258080(EHMT1) 664651(SUV39H2) 767626(SUV39H1)
CFR: 102512057(SETDB1) 102512972(SUV39H1) 102514882(PRDM2) 102514903(SETDB2) 102518579(EHMT2) 102521199(SUV39H2) 102521526(EHMT1)
CDK: 105087443(EHMT2) 105101932 105102102(EHMT1) 105103196(SETDB1) 105103308(SUV39H1) 105104521(SUV39H2) 105107110(PRDM2)
BACU: 102999710(SUV39H2) 103005831(SUV39H1) 103009894(SETDB1) 103017152(SETDB2) 103017744(EHMT1) 103018553(EHMT2) 103020862(PRDM2)
LVE: 103068757(SETDB2) 103072310(EHMT2) 103073919(SUV39H1) 103076461(SETDB1) 103079038(EHMT1) 103083070(PRDM2) 103084616(SUV39H2) 103088198
OOR: 101269551(PRDM2) 101270688(SETDB1) 101272833(EHMT1) 101275448(SETDB2) 101279239(SUV39H2) 101282385(EHMT2) 101289196(SUV39H1)
DLE: 111169525(SUV39H1) 111169744(SETDB1) 111170699(EHMT2) 111175303 111176964(EHMT1) 111178089(SUV39H2) 111187234(PRDM2)
PCAD: 102974835(PRDM2) 102978732(EHMT1) 102981491 102988226(SUV39H2) 102988363(SUV39H1) 102990347(SETDB2) 102993056(EHMT2) 114486049 114486183
ECB: 100054973(PRDM2) 100056120(SETDB2) 100058869(EHMT1) 100059118(EHMT2) 100059254(SETDB1) 100062108(SUV39H1) 100068891(SUV39H2)
EPZ: 103544360 103544897(SUV39H1) 103547642(SETDB1) 103554163(EHMT1) 103556824(SUV39H2) 103563300(EHMT2) 103563428(SETDB2) 103564688(PRDM2)
EAI: 106822324(EHMT2) 106822761(EHMT1) 106827436(SUV39H1) 106828015(PRDM2) 106829693(SETDB2) 106840452(SUV39H2) 106846522(SETDB1)
MYB: 102243180(SUV39H1) 102245485(EHMT1) 102248401(SETDB2) 102249747(PRDM2) 102257713(SETDB1) 102260054(SUV39H2) 102263672(EHMT2)
MYD: 102756540(EHMT1) 102757145(SUV39H2) 102760935(PRDM2) 102763954(SUV39H1) 102765299(SETDB2) 102773684(SETDB1) 102773857(EHMT2)
MNA: 107531408(SETDB2) 107531564 107534821(SUV39H2) 107536199(EHMT1) 107538997(EHMT2) 107539129(SETDB1) 107541392(SUV39H1)
HAI: 109372277(SETDB1) 109373117(EHMT2) 109374812(SUV39H1) 109381271(PRDM2) 109382055(EHMT1) 109387125(SETDB2) 109393823(SUV39H2)
DRO: 112299124(PRDM2) 112302258(EHMT2) 112306260(EHMT1) 112313171 112313537(SETDB1) 112320455(SUV39H2) 112322458(SUV39H1)
PALE: 102879374(EHMT2) 102879589(PRDM2) 102886191(SETDB1) 102891996 102893102(EHMT1) 102894853(SUV39H1) 102898400(SUV39H2)
RAY: 107498490(EHMT2) 107499036(SETDB1) 107503067(EHMT1) 107504834(SUV39H2) 107505354 107510017(SETDB2) 107513143(PRDM2) 107515026(SUV39H1)
MJV: 108389857 108397103(SUV39H2) 108397963(PRDM2) 108400840(EHMT2) 108403560(SETDB2) 108404637 108405374(EHMT1) 108408400(SUV39H1) 108409453(SETDB1)
LAV: 100653780(SUV39H1) 100658021(PRDM2) 100659207(EHMT2) 100660736(EHMT1) 100670438 100673374(SETDB1) 100674328(SUV39H2) 104847199
MDO: 100010516(PRDM2) 100014806(SUV39H2) 100018670(SUV39H1) 100023838(EHMT1) 100025360(EHMT2) 100028710(SETDB2) 100618580(SETDB1)
SHR: 100922258(SUV39H1) 100928904(SETDB1) 100931147(EHMT2) 100932927(EHMT1) 100933751(SUV39H2) 100934863
PCW: 110198885(PRDM2) 110199440(EHMT2) 110201087(SUV39H1) 110205249(EHMT1) 110213411(SETDB2) 110217388(SUV39H2) 110220597(SETDB1)
OAA: 100078328(EHMT1) 100082943(EHMT2) 100083315(SETDB2) 100084051(SUV39H1) 100085175(SUV39H2) 100091318(SETDB1) 100681503(PRDM2)
GGA: 100859816(SETDB1) 112529925 112529927(SUV39H1) 395847(MLLT11) 417250(EHMT1) 418866(SETDB2) 419478(PRDM2) 426314(SUV39H2)
CJO: 107307203(SUV39H1) 107308162(SETDB2) 107308165(PHF11) 107319605(SUV39H2) 107321652(EHMT1) 107323354(PRDM2) 107324577(SETDB1)
NMEL: 110387900(SETDB1) 110391539(SUV39H1) 110392282(SUV39H2) 110402348 110406734(EHMT1) 110408674(PRDM2)
APLA: 101790074 101794756(SETDB1) 101795723(PRDM2) 101796000(SUV39H2) 101805087(EHMT1)
ACYG: 106035063(PHF11) 106035084(SETDB2) 106037080(EHMT1) 106040216(PRDM2) 106046190(SUV39H2) 106049268(SETDB1)
LSR: 110469585 110470972(SUV39H2) 110476787(PRDM2) 110476821(SETDB1) 110476956(EHMT1) 110481760(SUV39H1) 110482327
GFR: 102031848(SUV39H2) 102034546(SETDB1) 102036198(EHMT1) 102043625(SETDB2) 102043786(PHF11) 106631968(PRDM2)
FAB: 101806838(EHMT1) 101812782(PRDM2) 101812936(PHF11) 101814584 101816158(SUV39H2)
PHI: 102099526(EHMT1) 102101563(SETDB1) 102103897(PHF11) 102104074(SETDB2) 102106085 102110616(SUV39H1) 102111894(PRDM2) 102114300(SUV39H2) 106629066
PMAJ: 107204624(SUV39H2) 107211503 107212039(EHMT1) 107213672(PRDM2) 107214655(SETDB1)
CCAE: 111923103(SUV39H2) 111935294 111936927(EHMT1) 111938730(PRDM2) 111939473(SETDB1)
CCW: 104688230(EHMT1) 104689965 104693258(PRDM2) 104694491(SUV39H2)
ETL: 114060918 114065121(PRDM2) 114067139(EHMT1) 114067551(SUV39H2) 114071955(SETDB1) 114073290 114073634
FPG: 101912073(SETDB1) 101912234(PHF11) 101912815(SUV39H2) 101914490(PRDM2) 101916063(EHMT1) 101917763(SETDB2)
FCH: 102055212(SETDB1) 102055395 102057247(EHMT1) 102059458(SUV39H2) 106631029(PRDM2)
CLV: 102085960(EHMT1) 102088543 102092575(PRDM2) 102094505(SETDB1) 102098917(SUV39H2)
EGZ: 104124045(EHMT1) 104129700(SETDB1) 104131606(SETDB2) 104131607(PHF11) 104132393(SUV39H2) 104133098(PRDM2)
NNI: 104009017 104010895(PHF11) 104010896(SETDB2) 104014430(SETDB1) 104014630(SUV39H2) 104022219(EHMT1)
ACUN: 113486655(EHMT1) 113487883(PRDM2) 113488725(SETDB1) 113489224(SETDB2) 113489768(SUV39H2)
PADL: 103913457(PHF11) 103913458(SETDB2) 103915032(SUV39H2) 103918059(PRDM2) 103918930(EHMT1) 103919479(SETDB1)
AAM: 106482427(PRDM2) 106485143(SUV39H2) 106489242(PHF11) 106489246(SETDB2) 106493032(EHMT1) 106495416(SETDB1)
ASN: 102371718(PRDM2) 102374916(EHMT1) 102375358(SUV39H2) 102378805(SUV39H1) 102380189 102381770(EHMT2) 102382539(SETDB1)
AMJ: 102558468(SUV39H1) 102561958(PRDM2) 102563656(SUV39H2) 102564850(EHMT1) 102574756(EHMT2) 102575637(SETDB1) 102576351(SETDB2)
CMY: 102932556(PHF11) 102932781(SETDB2) 102933671(EHMT1) 102937045(SUV39H2) 102937828(SETDB1) 102937831(SUV39H1) 102942942(PRDM2)
CPIC: 101931963(SETDB1) 101939547(PRDM2) 101942163(EHMT1) 101945875(SUV39H2) 101947321(EHMT2) 101950077(PHF11) 101950365(SETDB2) 101951503(SUV39H1)
ACS: 100552443(setdb2) 100553897(suv39h1) 100556375(ehmt2) 100565730(ehmt1) 100565799(setdb1) 100567365(prdm2)
PVT: 110072610 110080651(SETDB2) 110080653(PHF11) 110081193(SUV39H1) 110081479(SETDB1) 110088696(EHMT2) 110089799(EHMT1)
PBI: 103049261(EHMT2) 103052540(SUV39H1) 103053131(SETDB1) 103053645 103057390(EHMT1) 103060604(PRDM2) 103067345 107326457(PHF11)
PMUR: 107283956 107284269(SETDB2) 107291380(PRDM2) 107292899(SETDB1) 107295037(EHMT2) 107297347(EHMT1) 107300048(SUV39H1) 107302473
PMUA: 114583936 114586177(SETDB1) 114588136(SUV39H1) 114589035(EHMT1) 114592073(EHMT2) 114593254(SETDB2) 114602405(PRDM2)
GJA: 107105480(EHMT2) 107106223(PRDM2) 107112843(SUV39H1) 107113385(SETDB2) 107118801(EHMT1) 107119301 107119302 107121584(SETDB1)
XLA: 100037174(suv39h2.L) 108696585(prdm2.L) 108698163(ehmt1.L) 108698559(ehmt2.L) 108699889(ehmt1.S) 108700299(suv39h1.S) 108700333(setdb1.S) 108713053(suv39h2.S) 398711(setdb2.S) 431943(suv39h1.L) 432147(setdb1.L) 494709(prdm2.S)
XTR: 100124713(ehmt1) 100124743(setdb2) 100170624(prdm2) 100484992(ehmt2) 100490309(setdb1) 549262(suv39h2)
NPR: 108783946(PRDM2) 108786543(EHMT2) 108788266(SUV39H1) 108789810(SETDB1) 108794066(SUV39H2) 108794390(EHMT1) 108797823(SETDB2)
DRE: 100003615(prdm2a) 100005761(ehmt1a) 326906(suv39h1b) 335153(setdb2) 402830(ehmt1b) 445198(suv39h1a) 553292(setdb1a) 569250(ehmt2) 768131(setdb1b) 797296(prdm2b)
CSEM: 103384853(suv39h1) 103384937 103385671(prdm2) 103388279(setdb1) 103389041 103389803(setdb2) 103394057(ehmt2) 103394578 103397363
SFM: 108918498(prdm2) 108922673(ehmt1) 108923796(setdb1) 108924930 108934780(suv39h1) 108935584(ehmt2) 108937739 108938542
LCM: 102351913 102356699(SETDB1) 102359250(PRDM2) 102359445(EHMT2) 102360554(SUV39H2) 102361297(EHMT1) 102363588(SETDB2) 106705364
CMK: 103173106 103180404(ehmt1) 103181338(prdm2)
RTP: 109911717(setdb2) 109919887(ehmt2) 109921345(suv39h2) 109925832 109926709(ehmt1) 109937263(prdm2)
DME: Dmel_CG12196(egg) Dmel_CG2995(G9a) Dmel_CG43664(Su(var)3-9) Dmel_CG43665(eIF2gamma)
DSI: Dsimw501_GD16494(Dsim_GD16494) Dsimw501_GD24920(Dsim_GD24920)
BMOR: 101742950 101743644 692623(Su(var)3-9)
CEL: CELE_R05D3.11(met-2)
CBR: CBG18157(Cbr-met-2)
TSP: Tsp_05330
EGL: EGR_06122
ATH: AT1G17770(SUVH7) AT1G73100(SUVH3) AT2G22740(SUVH6) AT2G24740(SDG21) AT2G33290(SUVH2) AT2G35160(SUVH5) AT4G13460(SUVH9) AT5G04940(SUVH1) AT5G13960(SUVH4)
LJA: Lj0g3v0007239.1(Lj0g3v0007239.1) Lj0g3v0128679.1(Lj0g3v0128679.1) Lj0g3v0265609.1(Lj0g3v0265609.1) Lj0g3v0266169.1(Lj0g3v0266169.1) Lj0g3v0269559.1(Lj0g3v0269559.1) Lj0g3v0293009.1(Lj0g3v0293009.1) Lj1g3v3904410.1(Lj1g3v3904410.1) Lj1g3v4059050.1(Lj1g3v4059050.1) Lj2g3v1989010.1(Lj2g3v1989010.1) Lj2g3v1989010.2(Lj2g3v1989010.2) Lj2g3v1989010.3(Lj2g3v1989010.3) Lj2g3v1989020.1(Lj2g3v1989020.1) Lj2g3v1989030.1(Lj2g3v1989030.1) Lj2g3v1989040.1(Lj2g3v1989040.1) Lj2g3v1989040.2(Lj2g3v1989040.2) Lj5g3v2244670.1(Lj5g3v2244670.1) Lj6g3v0156100.1(Lj6g3v0156100.1) Lj6g3v0156120.1(Lj6g3v0156120.1)
DOSA: Os01t0811300-01(Os01g0811300) Os01t0927000-01(Os01g0927000) Os03t0320400-01(Os03g0320400) Os04t0544100-01(Os04g0544100) Os05t0490700-01(Os05g0490700) Os07t0435900-01(Os07g0435900) Os08t0399300-00(Os08g0399300) Os08t0400000-01(Os08g0400000) Os08t0400200-00(Os08g0400200) Os08t0565700-01(Os08g0565700) Os09t0362900-01(Os09g0362900) Os11t0131600-00(Os11g0131600) Os11t0602200-01(Os11g0602200) Os12t0128450-00(Os12g0128450)
ATS: 109741537(LOC109741537) 109741621 109744867(LOC109744867) 109746199(LOC109746199) 109749138(LOC109749138) 109749619(LOC109749619) 109750455(LOC109750455) 109751482(LOC109751482) 109761403(LOC109761403) 109766085(LOC109766085) 109769949(LOC109769949) 109769961(LOC109769961) 109770115 109771886 109774279(LOC109774279) 109777308(LOC109777308) 109782755(LOC109782755)
CRE: CHLREDRAFT_6823(SET3)
VCN: VOLCADRAFT_93418(VSET3)
NCR: NCU04402(dim-5)
NTE: NEUTE1DRAFT121214(NEUTE1DRAFT_121214)
MGR: MGG_06852
SSCK: SPSK_07647
NHE: NECHADRAFT_94199(SDG2104)
MAW: MAC_09094
MAJ: MAA_00272
CMT: CCM_00746
BFU: BCIN_11g02360(BcDIM5)
MBE: MBM_05751
ANI: AN1170.2
ANG: ANI_1_1828074(An08g03380)
ABE: ARB_02816
TVE: TRV_01916
PTE: PTT_11395
ZTR: MYCGRDRAFT_107709(SDG2411)
SPO: SPBC428.08c(clr4)
CNE: CNH00720
CNB: CNBL0680
LBC: LACBIDRAFT_296206(SDG16210)
ABP: AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)
ABV: AGABI2DRAFT146074(AGABI2DRAFT_146074) AGABI2DRAFT180791(AGABI2DRAFT_180791)
DFA: DFA_00949(suvA)
 » show all
Taxonomy
Reference
1  [PMID:11094092]
  Authors
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T
  Title
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase  gene that displays testis-specific expression.
  Journal
Mol Cell Biol 20:9423-33 (2000)
  Sequence
[mmu:20937 64707]
Reference
2  [PMID:11867540]
  Authors
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G
  Title
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
  Journal
EMBO J 21:1121-31 (2002)
  Sequence
Reference
3  [PMID:12130538]
  Authors
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y
  Title
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
  Journal
Genes Dev 16:1779-91 (2002)
  Sequence
[mmu:110147]
Reference
4  [PMID:11959841]
  Authors
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd
  Title
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase  that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
  Journal
Genes Dev 16:919-32 (2002)
  Sequence
[hsa:9869]
Reference
5  [PMID:14633678]
  Authors
Kim KC, Geng L, Huang S
  Title
Inactivation of a histone methyltransferase by mutations in human cancers.
  Journal
Cancer Res 63:7619-23 (2003)
  Sequence
[hsa:7799]
Reference
6  [PMID:20084102]
  Authors
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M
  Title
Structural biology of human H3K9 methyltransferases.
  Journal
PLoS One 5:e8570 (2010)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.355
IUBMB Enzyme Nomenclature: 2.1.1.355
ExPASy - ENZYME nomenclature database: 2.1.1.355
BRENDA, the Enzyme Database: 2.1.1.355

KEGG   ENZYME: 2.1.1.356Help
Entry
EC 2.1.1.356                Enzyme                                 

Name
[histone H3]-lysine27 N-trimethyltransferase;
KMT6A (gene name);
KMT6B (gene name);
EZH1 (gene name);
EZH2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins.
History
EC 2.1.1.356 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.356
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1
Genes
HSA: 2145(EZH1) 2146(EZH2)
PTR: 454697(EZH1) 745437(EZH2)
PPS: 100967877(EZH1) 100971244(EZH2)
GGO: 101126515(EZH1) 101147968(EZH2)
PON: 100171872(EZH1) 100447447(EZH2)
NLE: 100580962(EZH2) 100604860(EZH1)
MCC: 709075(EZH2) 711173(EZH1)
MCF: 102130547(EZH1) 102146280(EZH2)
CSAB: 103227182(EZH2) 103243395(EZH1)
RRO: 104667012(EZH2) 104680126(EZH1)
RBB: 108522307(EZH2) 108526767(EZH1)
CJC: 100394758(EZH2) 100411881(EZH1)
SBQ: 101038203(EZH1) 101051611(EZH2)
MMU: 14055(Ezh1) 14056(Ezh2)
MCAL: 110295592(Ezh2) 110304611(Ezh1)
MPAH: 110315211(Ezh2) 110331872(Ezh1)
RNO: 303547(Ezh1) 312299(Ezh2)
MUN: 110547503(Ezh2) 110550881(Ezh1)
CGE: 100758055(Ezh2) 100760595(Ezh1)
NGI: 103731383(Ezh2) 103735912(Ezh1)
HGL: 101702710(Ezh2) 101723063(Ezh1)
CCAN: 109687337(Ezh1) 109695508(Ezh2)
OCU: 100345157(EZH2) 100351852(EZH1)
TUP: 102485788(EZH1) 102495627(EZH2)
CFA: 475511(EZH2) 480516(EZH1)
VVP: 112910738(EZH1) 112934818(EZH2)
AML: 100466177(EZH2) 100472619(EZH1)
UMR: 103668955(EZH2) 103672584(EZH1)
UAH: 113241452(EZH2) 113265406(EZH1)
ORO: 101369941(EZH2) 101379551(EZH1)
FCA: 101087309(EZH2) 101099602(EZH1)
PTG: 102956220(EZH2) 102961028(EZH1)
PPAD: 109258535(EZH1) 109269218(EZH2)
AJU: 106972615(EZH1) 106981407(EZH2)
BTA: 509106(EZH2) 533087(EZH1)
BOM: 102276653(EZH1) 102287858(EZH2)
BIU: 109557756(EZH2) 109573994(EZH1)
BBUB: 102405899(EZH2) 102407322(EZH1)
CHX: 102189343(EZH1) 102190101(EZH2)
OAS: 101104765(EZH1) 101120745(EZH2)
SSC: 100518394(EZH1) 100625497(EZH2)
CFR: 102515793(EZH2) 102516907(EZH1)
CDK: 105085196(EZH2) 105090473(EZH1) 116154104
LVE: 103069623(EZH2) 103073364(EZH1)
OOR: 101280796(EZH2) 101285746(EZH1)
DLE: 111166246(EZH1) 111177205(EZH2)
PCAD: 102994010(EZH2) 102994197(EZH1) 112061879
ECB: 100051290(EZH2) 100052411(EZH1)
EPZ: 103545927 103550351(EZH1) 103553703(EZH2)
EAI: 106826432(EZH1) 106842131(EZH2)
MYB: 102246299(EZH2) 102259730(EZH1)
MYD: 102755313(EZH1) 102768989(EZH2)
MNA: 107523768(EZH2) 107528927(EZH1)
HAI: 109395452(EZH2) 109395755(EZH1)
DRO: 112298572(EZH1) 112308348(EZH2)
PALE: 102879627(EZH1) 102886689(EZH2)
RAY: 107500533(EZH2) 107513838(EZH1)
MJV: 108386069(EZH1) 108386657(EZH2)
LAV: 100664312(EZH2) 100673691(EZH1)
MDO: 100010738(EZH1) 100013390(EZH2)
SHR: 100926678(EZH2) 100932535(EZH1)
PCW: 110198374(EZH1) 110201666(EZH2)
OAA: 100073485(EZH2) 100082851(EZH1)
GGA: 420023(EZH1) 420784(EZH2)
MGP: 100540374(EZH2) 100547448(EZH1)
CJO: 107309835(EZH2) 107325326(EZH1)
NMEL: 110388515(EZH1) 110390789(EZH2)
APLA: 101791765(EZH1) 101793453(EZH2)
ACYG: 106048025(EZH1) 106048735(EZH2)
TGU: 100226728(EZH2) 100227472(EZH1)
LSR: 110471820(EZH1) 110479186(EZH2)
SCAN: 103819367(EZH2) 103821570(EZH1)
GFR: 102035477(EZH1) 102038673(EZH2)
FAB: 101809240(EZH2) 101811414(EZH1)
PHI: 102099930(EZH2) 102103576(EZH1)
PMAJ: 107200653(EZH2) 107215126(EZH1)
CCAE: 111923642(EZH2) 111940096(EZH1)
CCW: 104688925(EZH2) 104697765(EZH1)
ETL: 114063607(EZH1) 114063865(EZH2)
FPG: 101911332(EZH2) 101915579(EZH1)
FCH: 102052374(EZH1) 102055584(EZH2)
CLV: 102093761(EZH2) 102097006(EZH1)
EGZ: 104125781(EZH2) 104134781(EZH1)
NNI: 104009878(EZH1) 104015388(EZH2)
ACUN: 113477549(EZH2) 113489070
PADL: 103916088(EZH2) 103919098(EZH1)
AAM: 106491114(EZH1) 106495267(EZH2)
ASN: 102372569(EZH2) 102383438(EZH1)
AMJ: 102562122(EZH2) 102566481(EZH1)
PSS: 102453330(EZH2) 102463087(EZH1)
CMY: 102932650(EZH2) 102934538(EZH1)
CPIC: 101934118(EZH1) 101937752(EZH2)
ACS: 100559669(ezh1) 100564989(ezh2)
PVT: 110080273(EZH1) 110088673(EZH2)
PBI: 103051581(EZH2) 103052924(EZH1)
PMUR: 107288847(EZH2) 107290401 107302416(EZH1)
TSR: 106547020(EZH2) 106554239(EZH1)
PMUA: 114581626(EZH1) 114607413(EZH2)
GJA: 107119624(EZH2) 107123351(EZH1)
XLA: 100381148(ezh2.S) 108701022(ezh1.L) 108702719(ezh1.S) 399174(ezh2.L)
XTR: 100493532(ezh1) 550047(ezh2)
NPR: 108794364(EZH2) 108796324(EZH1)
DRE: 664754(ezh1) 768133(ezh2)
IPU: 108256455(ezh2) 108279279(ezh1)
PHYP: 113528051(ezh1) 113541351(ezh2)
AMEX: 103027230(ezh2) 103044086(ezh1)
EEE: 113589064(ezh2) 113590056
TRU: 101068728(ezh2) 101070195(ezh1)
LCO: 104923910(ezh1) 104933871(ezh2)
NCC: 104940789(ezh2) 104944052
MZE: 101464777 101474304(ezh1) 112429845(ezh2)
ONL: 100695015(ezh1) 100702594(ezh2)
OLA: 100125823(ezh2) 101166385(ezh1)
XMA: 102218572(ezh2) 102228014(ezh1)
XCO: 114136427(ezh2) 114160264(ezh1)
PRET: 103457011(ezh2) 103468644(ezh1) 103469387
CVG: 107091776(ezh1) 107097879(ezh2)
NFU: 107378461(ezh1) 107383138(ezh2)
KMR: 108243802(ezh1) 108249555(ezh2)
ALIM: 106511331 106528219(ezh1) 106531656(ezh2)
AOCE: 111564547(ezh1) 111570645(ezh2)
CSEM: 103377188(ezh2) 103393149(ezh1) 103399469
LCF: 108884998(ezh2) 108900993(ezh1)
SDU: 111217595(ezh1) 111238320(ezh2)
SLAL: 111647273(ezh2) 111660565(ezh1)
HCQ: 109508596 109521815(ezh2)
BPEC: 110158320(ezh2) 110166859(ezh1)
MALB: 109951056(ezh2) 109964204(ezh1)
ELS: 105013194(ezh1) 105022040(ezh2)
LCM: 102364190(EZH1)
CMK: 103187005(ezh2)
CIN: 100177449
SPU: 585842
APLC: 110990448
DME: Dmel_CG6502(E(z))
DER: 6546346
DSI: Dsimw501_GD12857(Dsim_GD12857)
DSR: 110185151
DPE: 6601386
DMN: 108151423
DWI: 6646360
DAZ: 108614083
DNV: 108652219
MDE: 101887292
LCQ: 111677283
AAG: 5577466
AALB: 109401157
AME: 552235
BIM: 100747000
BTER: 100647736
CCAL: 108631087
OBB: 114880742
SOC: 105197183
MPHA: 105835069
AEC: 105143480
ACEP: 105617407
PBAR: 105425935
VEM: 105559070
DQU: 106746421
CFO: 105250747
LHU: 105670949
PGC: 109855910
OBO: 105285382
PCF: 106792137
NVI: 100113526
CSOL: 105367879
TCA: 659759
DPA: 109536169
NVL: 108560889
BMOR: 101739540 101745450(E(Z))
BMAN: 114243273
PMAC: 106718913
PRAP: 110995414
HAW: 110375985
TNL: 113498098
API: 100168406
DNX: 107161946
AGS: 114123060
RMD: 113551950
BTAB: 109035984
CLEC: 106666006
ZNE: 110841374
DPTE: 113792645
PTEP: 107455687
CEL: CELE_R06A4.7(mes-2)
CBR: CBG11099(Cbr-mes-2)
BMY: Bm1_55060
TSP: Tsp_01566
PCAN: 112556350
CRG: 105330640
MYI: 110442389
OBI: 106874217
LAK: 106181368
EGL: EGR_02209
EPA: 110249650
AMIL: 114967312
PDAM: 113673889
SPIS: 111323365
DGT: 114531596
HMG: 100201207
AQU: 109587656
ATH: AT1G02580(MEA) AT2G23380(CLF) AT4G02020(SWN)
LJA: Lj0g3v0213049.1(Lj0g3v0213049.1) Lj2g3v1890940.1(Lj2g3v1890940.1) Lj2g3v1890940.2(Lj2g3v1890940.2) Lj5g3v1598420.1(Lj5g3v1598420.1) Lj5g3v1598420.2(Lj5g3v1598420.2) Lj5g3v1598420.3(Lj5g3v1598420.3) Lj5g3v1598420.4(Lj5g3v1598420.4)
SLY: 100134891(EZ1) 100134892(EZ2) 101267964
DOSA: Os03t0307800-01(Os03g0307800) Os06t0275500-01(Os06g0275500)
ATS: 109742834(LOC109742834) 109781663(LOC109781663) 109781665(LOC109781665)
ZMA: 541954(mez1) 541955(mez3) 542659(mez2)
PPP: 112274954
MNG: MNEG_1960
MBE: MBM_04736
PTE: PTT_08614
ZTR: MYCGRDRAFT_71291(SDG2401)
LBC: LACBIDRAFT_312288(SDG16204)
 » show all
Taxonomy
Reference
1  [PMID:12351676]
  Authors
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y
  Title
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
  Journal
Science 298:1039-43 (2002)
  Sequence
[hsa:2146]
Reference
2  [PMID:12435631]
  Authors
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D
  Title
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
  Journal
Genes Dev 16:2893-905 (2002)
  Sequence
[hsa:2146]
Reference
3  [PMID:15231737]
  Authors
Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ
  Title
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
  Journal
Genes Dev 18:1592-605 (2004)
  Sequence
[hsa:2146]
Reference
4  [PMID:17200670]
  Authors
Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff BE, Bergman Y, Simon I, Cedar H
  Title
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo  methylation in cancer.
  Journal
Nat Genet 39:232-6 (2007)
  Sequence
[hsa:2146]
Reference
5  [PMID:19026780]
  Authors
Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH
  Title
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
  Journal
Mol Cell 32:491-502 (2008)
  Sequence
[mmu:14055 14056]
Reference
6  [PMID:21317239]
  Authors
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E
  Title
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.
  Journal
Genes Dev 25:485-98 (2011)
  Sequence
[mmu:14055 14056]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.356
IUBMB Enzyme Nomenclature: 2.1.1.356
ExPASy - ENZYME nomenclature database: 2.1.1.356
BRENDA, the Enzyme Database: 2.1.1.356

KEGG   ENZYME: 2.1.1.357Help
Entry
EC 2.1.1.357                Enzyme                                 

Name
[histone H3]-lysine36 N-dimethyltransferase;
KMT3B (gene name);
KMT3C (gene name);
NSD2 (gene name);
NSD3 (gene name);
SETMAR (gene name);
WHSC1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
Reaction(KEGG)
(other) R03875 R04866
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine36;
[histone H3]-N6-methyl-L-lysine36
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6-dimethyl-L-lysine36;
[histone H3]-N6-methyl-L-lysine36
Comment
This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. The product can be further methylated to the trimethyl form by EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase. The yeast SET2 enzyme can catalyse all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase).
History
EC 2.1.1.357 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.357
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11424  [histone H3]-lysine36 N-dimethyltransferase NSD2
K11425  [histone H3]-lysine36 N-dimethyltransferase NSD3
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD
K11433  [histone H3]-lysine36 N-dimethyltransferase SETMAR
K15588  [histone H3]-lysine36 N-dimethyltransferase NSD1
Genes
HSA: 150572(SMYD1) 54904(NSD3) 56950(SMYD2) 6419(SETMAR) 64324(NSD1) 64754(SMYD3) 7468(NSD2)
PTR: 457729(SMYD2) 457870(SMYD3) 459386(SMYD1) 461070(NSD2) 464119(NSD3) 470738 471754(NSD1)
PPS: 100971786(SMYD2) 100983230(SMYD1) 100986203(SETMAR) 100989573(NSD3) 100990317(SMYD3) 100991882(NSD1) 100993332(NSD2) 106635114
GGO: 101127408(NSD3) 101130126(NSD1) 101140725(NSD2) 101145998(SMYD3) 101146341(SMYD1) 101147890(SMYD2) 101150409 109028619
PON: 100172280(SMYD1) 100433878(NSD2) 100439269(SMYD3) 100439768(SMYD2) 100447656 100459660(NSD3) 100461473(NSD1)
NLE: 100579604(SMYD3) 100583251(NSD1) 100586616 100586897(NSD2) 100599595(NSD3) 100603309(SMYD2) 100603551(SMYD1) 115836349
MCC: 100429321(NSD2) 698950(SMYD1) 700254(NSD3) 703402(SMYD3) 703880 706131(NSD1) 709375(SMYD2)
MCF: 101867194 102120149(SMYD3) 102120529(NSD1) 102120758(SMYD1) 102132914(NSD2) 102138188(NSD3) 102141885(SMYD2)
CSAB: 103215646(NSD3) 103227932(SETMAR) 103230106(SMYD2) 103230910(SMYD3) 103241358(SMYD1) 103245045(NSD1) 103246476(NSD2)
RRO: 104664288 104669844(SMYD2) 104674171(SMYD1) 104676513(SMYD3) 104678937(NSD2) 104679642(NSD3) 104680450(NSD1) 115893950
CJC: 100385401(SETMAR) 100388751(SMYD1) 100389349(NSD3) 100392519(SMYD3) 100404005(SMYD2) 100405201(NSD1) 100407883(NSD2) 100894411
SBQ: 101030617 101031525(WHSC1L1) 101039502(SMYD3) 101043413(SMYD1) 101050442(SMYD2) 101052056(WHSC1) 101052510(NSD1)
MMU: 107823(Nsd2) 12180(Smyd1) 18193(Nsd1) 226830(Smyd2) 234135(Nsd3) 69726(Smyd3) 74729(Setmar)
MCAL: 110290320(Smyd3) 110294647(Nsd2) 110296132(Smyd1) 110296632 110298532(Smyd2) 110299577(Nsd3) 110308568(Nsd1)
MPAH: 110316349(Smyd1) 110317184 110321293(Smyd3) 110322084(Smyd2) 110330238(Nsd2) 110334011(Nsd1) 110337154(Nsd3)
RNO: 289372(Smyd2) 290831(Nsd3) 297333(Smyd1) 306764(Nsd1) 498295(Smyd3) 500281(Setmar) 680537(Nsd2)
MUN: 110549759(Nsd1) 110552137 110553406(Smyd2) 110557276(Nsd2) 110557574(Smyd3) 110562254(Smyd1) 110563304(Nsd3)
CGE: 100761694(Smyd2) 100763780(Nsd2) 100764148 100764840(Smyd3) 100766221(Smyd1) 100773097(Nsd3) 100773206(Nsd1)
NGI: 103727065(Smyd2) 103732357(Nsd1) 103737043(Smyd1) 103741129(Nsd2) 103745768(Nsd3) 103746872(Smyd3) 103751200
HGL: 101698401(Nsd1) 101703406(Nsd3) 101704237(Setmar) 101709487(Nsd2) 101718535(Smyd1) 101720447(Smyd2) 101722574(Smyd3)
CCAN: 109674462 109675706(Smyd3) 109685765(Nsd1) 109688938(Nsd3) 109694996(Nsd2) 109696831 109700578(Smyd1) 109700718(Smyd2)
OCU: 100344249(SMYD2) 100346827 100347516(SMYD3) 100347860(NSD2) 100352710(NSD3) 100355437(SMYD1) 100355926(NSD1)
TUP: 102469064(SETMAR) 102476810(NSD1) 102483290(SMYD3) 102487161(NSD3) 102493552(SMYD1) 102496151(SMYD2) 102501548(NSD2) 102502765
CFA: 475584(NSD3) 475758(SMYD1) 476549(SETMAR) 479077(NSD2) 480026(SMYD2) 480101(SMYD3) 489094(NSD1)
VVP: 112908887 112916135(NSD3) 112916807(SMYD1) 112920183(NSD2) 112921783(SMYD2) 112923542(SMYD3) 112925575(NSD1)
AML: 100466350(SMYD3) 100466490(SMYD2) 100467918 100473259 100474149(WHSC1L1) 100477428(NSD1) 100482078(NSD2) 100483766(SMYD1) 109490334
UMR: 103659130(NSD3) 103664453(NSD1) 103666923(SMYD3) 103669600 103671476(SMYD1) 103672523(SMYD2) 103676545(NSD2)
UAH: 113242840(SMYD1) 113245739(NSD2) 113257110 113262089(NSD3) 113262691(SMYD2) 113262946(SMYD3) 113264138(NSD1)
ORO: 101364354(WHSC1L1) 101364358(SMYD1) 101368708 101371861(SMYD2) 101380596(NSD1) 101380855(WHSC1) 101384291 101384991(SMYD3)
FCA: 101081435(SMYD2) 101083169(NSD2) 101086901(NSD3) 101088560 101089231(SMYD3) 101095247(SMYD1) 101100618(NSD1)
PTG: 102949086(NSD3) 102949463(SMYD3) 102959131(WHSC1) 102964395(SETMAR) 102965041 102967043(NSD1) 102968240(SMYD2) 102970032(SMYD1)
PPAD: 109251114(SMYD3) 109254457(SMYD2) 109254649 109261817 109262146(NSD3) 109262306 109264245(SMYD1) 109267571(NSD1) 109269561(NSD2)
AJU: 106966796(SMYD2) 106968611(SMYD3) 106975404(NSD1) 106978140(SMYD1) 106978378(NSD3) 106978842(NSD2) 106978956
BTA: 511299(SETMAR) 513054(NSD3) 534913 537404(SMYD1) 540197(NSD1) 540769(NSD2) 615229(SMYD2) 616050(SMYD3)
BOM: 102264389(NSD2) 102265377 102268256(SETMAR) 102268569(NSD1) 102268973(NSD3) 102270977(SMYD1) 102273734(SMYD2) 102287417(SMYD3)
BIU: 109553299(NSD3) 109560728(NSD2) 109561894(NSD1) 109561895 109563294 109566148(SMYD1) 109566704(NUDT15) 109570555(SMYD3) 109570591(SMYD2) 109576394
CHX: 102171177(SMYD3) 102177756 102184804(NSD1) 102186471(NSD2) 102187140(SMYD1) 102188284(NSD3) 102189632(SETMAR) 102189783(SMYD2)
OAS: 101102409(SMYD2) 101103648(NSD2) 101108731(SMYD1) 101110273(SETMAR) 101112880(NSD3) 101116161(SMYD3) 101120917(NSD1) 101122242 114109367
SSC: 100294702(SMYD1) 100294706(SMYD2) 100294707(SMYD3) 100514009 100515039(NSD2) 100520868(NSD3) 100524976(NSD1)
CFR: 102509336(NSD1) 102513005(SMYD1) 102513372(NSD2) 102514741(SMYD3) 102515779(NSD3) 102515785(SMYD2) 102523255(SETMAR)
CDK: 105089934(NSD3) 105093158 105099293(SMYD2) 105099491(SMYD3) 105099584 105100861(NSD2) 105104177(SMYD1)
BACU: 102998442(NSD2) 103008807(SETMAR) 103015430(NSD1) 103016894(NSD3) 103018045(SMYD3) 103018379(SMYD1) 103020103(SMYD2)
LVE: 103070332(SMYD1) 103072101(NSD3) 103079235(NSD1) 103081140(SMYD3) 103084286(SETMAR) 103085661(NSD2) 103090372(SMYD2)
OOR: 101271862(SMYD2) 101272234(WHSC1) 101278000 101278951(WHSC1L1) 101279526(NSD1) 101281657(SMYD3) 101284649(SMYD1)
PCAD: 102980789(SMYD1) 102985495(NSD1) 102987462 102989011(SMYD3) 102990993(NSD3) 102992344(SMYD2) 102996664(NSD2) 112063839 114485290
ECB: 100051090(NSD2) 100052774(SMYD2) 100052805(SMYD1) 100057692(NSD3) 100058570(NSD1) 100059267(SMYD3) 100059905
EAI: 106823803(NSD2) 106824653(NSD3) 106827129(NSD1) 106838574(SMYD1) 106846818(SMYD2) 106846844(SMYD3) 106848471
MYD: 102755932(SMYD1) 102759770(NSD3) 102760242 102760582(SMYD2) 102761804(SETMAR) 102764830(NSD1) 102769466(SMYD3) 102775482(NSD2)
MNA: 107524081 107524116 107528337(SMYD3) 107528646(SMYD1) 107529141 107529770(NSD1) 107535114(WHSC1L1) 107546243(SMYD2)
DRO: 112297714(SMYD2) 112303106(SMYD1) 112306746(NSD3) 112309943 112316764(NSD2) 112318753(SMYD3) 112320360(NSD1)
PALE: 102877851(NSD2) 102879344(NSD3) 102879695(NSD1) 102880671(SMYD1) 102883630(SMYD2) 102887843(SMYD3) 102895479
RAY: 107498661(SMYD3) 107504114 107505913(SMYD1) 107515960(WHSC1L1) 107517519(NSD1) 107517985(WHSC1) 107521612 107521638(SMYD2)
LAV: 100659534(SMYD3) 100661536 100663420(NSD3) 100672481(NSD1) 100672564(SMYD1) 100673480(NSD2) 100674556(SMYD2)
MDO: 100022449(SETMAR) 100022914(NSD2) 100023305(SMYD2) 100029674(SMYD1) 100029834(NSD3) 100031881(NSD1) 100619798(SMYD3)
SHR: 100913201(NSD1) 100913447(NSD2) 100913907(NSD3) 100916165(SMYD1) 100918271 100932883(SMYD3) 100934440(SMYD2)
PCW: 110195620 110196348(SMYD1) 110205493(SMYD3) 110207576(NSD3) 110212243(NSD2) 110216684(NSD1) 110222694(SMYD2)
OAA: 100074284(NSD3) 100075708 100078649(SMYD1) 100079176(SMYD2) 100082753(SMYD3) 100085446(NSD1) 100086259(NSD2)
GGA: 101747682(SETMAR) 373960(SMYD1) 416214(NSD1) 421361(SMYD2) 421489(SMYD3) 422897(WHSC1) 426778(WHSC1L1)
CJO: 107311083(SMYD2) 107311243(SMYD3) 107313892(NSD2) 107314020(SMYD1) 107319934 107320315(NSD1) 107323733(NSD3)
NMEL: 110387045(NSD3) 110395863(SMYD3) 110396134(SMYD2) 110397470(NSD2) 110398544(SMYD1) 110404782 110405534(NSD1)
APLA: 101789499(NSD1) 101790791(SMYD2) 101792888(NSD2) 101794070 101796335(NSD3) 101800831(SMYD1) 101801343(SMYD3) 106020314(GVQW3)
ACYG: 106031578(SMYD2) 106033933(SMYD1) 106034357(WHSC1) 106036705 106044410(WHSC1L1) 106049510(NSD1) 106049693(SMYD3)
TGU: 100219515(NSD1) 100219723(SMYD3) 100222344 100222807(NSD2) 100224170(NSD3) 100230154(SMYD1) 100230503(SMYD2)
LSR: 110469849 110470818(NSD1) 110473288(NSD2) 110473308(SMYD1) 110473395(NSD3) 110479948(SMYD2) 110481707(SMYD3)
SCAN: 103817363(NSD1) 103817699(SMYD3) 103821549(SMYD2) 103822694(NSD3) 103823501(SMYD1) 103823704 103823716(NSD2)
GFR: 102032923(SMYD2) 102033219(NSD2) 102033572(NSD3) 102034588(SETMAR) 102037071(SMYD1) 102037758(SMYD3) 102044678(NSD1)
FAB: 101807006(SMYD2) 101807043(NSD3) 101813052 101814945(NSD2) 101815424(NSD1) 101821319(SMYD3) 101822247(SMYD1)
PHI: 102101098(NSD1) 102101401(SMYD2) 102102416(SMYD1) 102104727(NSD3) 102105181(SETMAR) 102107307(SMYD3) 102113544(NSD2)
PMAJ: 107202071(SMYD2) 107202430(SMYD3) 107202885(WHSC1) 107203527(SMYD1) 107210432 107210674(NSD1) 107213840(WHSC1L1)
CCW: 104683515 104684478(SMYD3) 104685633(SMYD2) 104689518(NSD1) 104690790(NSD2) 104690813(SMYD1) 104694849(NSD3)
FPG: 101913589(NSD3) 101914789(NSD1) 101916059(NSD2) 101919056(SMYD1) 101919125(SMYD3) 101920720 101923412(SMYD2)
FCH: 102055251(NSD1) 102055544(NSD3) 102056334 102057033(SMYD1) 102057924(SMYD2) 102058880(SMYD3) 102059826(NSD2)
CLV: 102084521(NSD1) 102086496(SMYD1) 102088613(SMYD2) 102090497(NSD3) 102092665(SMYD3) 102095738(NSD2) 102096568 110359442
EGZ: 104125799(WHSC1L1) 104126982(SMYD1) 104128865(NSD1) 104130173(WHSC1) 104131533(SMYD3) 104132668 104132856(SMYD2) 104135262
NNI: 104011458(SMYD3) 104016016(WHSC1L1) 104017008 104018071(WHSC1) 104018532(SMYD1) 104018995(NSD1) 104019711(SMYD2)
ACUN: 113476295 113477910(SMYD3) 113478725(SMYD2) 113478988(NSD2) 113479169(SMYD1) 113484757 113485238(NSD1) 113488073(NSD3) 113489777
PADL: 103912352(WHSC1L1) 103914598(SMYD3) 103918809(NSD1) 103920916(WHSC1) 103922130(SMYD2) 103922491 103923505(SMYD1)
AAM: 106484901(SMYD1) 106485538(SMYD3) 106489717(NSD1) 106489795 106490428(SMYD2) 106493055(NSD3) 106498711(NSD2)
ASN: 102368053(SMYD1) 102368735(NSD1) 102372149(NSD2) 102381556(SMYD3) 102381990 102383161(SMYD2) 102385195(NSD3)
AMJ: 102562146(SETMAR) 102567385(NSD1) 102573644(NSD2) 102575326(SMYD2) 102575695(SMYD1) 102576362(SMYD3) 106736778(NSD3) 106739572 109282044
PSS: 102449156(SMYD1) 102456582(SMYD3) 102457400(NSD3) 102461265(SMYD2) 102461475 102461914 102464028(NSD2)
CMY: 102930063(NSD1) 102933435(SMYD2) 102936055(SMYD1) 102937036(SMYD3) 102940729(NSD2) 102942170(SETMAR) 102943320(NSD3)
CPIC: 101932511(NSD2) 101938886(NSD3) 101939705 101946646 101946796(NSD1) 101948178(SMYD2) 101951595(SMYD1) 101951981(SMYD3)
PVT: 110072168(NSD3) 110076069(SMYD3) 110077543(NSD1) 110077694 110085590(NSD2) 110086348(SMYD1) 110087176(SMYD2)
PBI: 103052345(SMYD3) 103052448(NSD1) 103054198(SMYD2) 103054838 103055475(NSD2) 103058624(SMYD1) 103067854(NSD3)
TSR: 106538415(SMYD2) 106540883(NSD1) 106549276(SMYD3) 106549317 106550185(SMYD1) 106550392(WHSC1L1) 106554241(WHSC1) 106557036
PMUA: 114582254(SMYD1) 114585486(NSD3) 114591437(NSD1) 114591815 114594456(SMYD3) 114594675(SMYD2) 114596957(NSD2)
GJA: 107105569(SMYD1) 107106688 107108065(SMYD3) 107111562(NSD1) 107112988(NSD3) 107121138 107121665(SMYD2) 107121904(NSD2)
XLA: 108697691(nsd2.L) 108706505 108710978(nsd1.L) 108711640(nsd3.L) 108712681 108712682 108713231(nsd1.S) 108714624(setmar.L) 108716123 108717409 379943(smyd2.S) 431996(nsd2.S) 443889(smyd1.L) 444415(smyd2-b)
XTR: 100125213(nsd2) 100135741(setmar) 100145429(smyd1) 100145675(nsd1) 100216035(nsd3) 100494527(smyd3) 100495522(smyd2)
NPR: 108783740(NSD1) 108783805(SMYD2) 108787486(SMYD3) 108788842(WHSC1) 108791911 108796886(SMYD1) 108800629(WHSC1L1)
DRE: 100000709(nsd2) 100006350(whsc1l1) 321245(smyd1a) 541423(smyd2a) 556086(nsd1a) 564575(setmar) 568616(smyd2b) 569027(smyd1b) 569507(smyd3)
LCM: 102346523(NSD1) 102349685(SMYD1) 102354519(SMYD2) 102359965(NSD3) 102361515(SMYD3) 102363237(NSD2) 102366478(SETMAR)
CMK: 103174199 103181513(smyd1) 103181738(smyd3) 103183116(nsd2) 103186165(smyd2) 103189717(nsd1) 103190419(nsd3)
DME: Dmel_CG13761(Smyd3) Dmel_CG4565(CG4565) Dmel_CG4976(NSD)
DSI: Dsimw501_GD18047(Dsim_GD18047) Dsimw501_GD18718(Dsim_GD18718) Dsimw501_GD29063(Dsim_GD29063)
CEL: CELE_R06F6.4(set-14) CELE_T22A3.4(set-18) CELE_Y41D4B.12(set-23) CELE_ZC8.3(set-30)
CBR: CBG03016(Cbr-set-14) CBG13569(Cbr-set-23) CBG14580(Cbr-set-30) CBG24752(Cbr-set-18)
ATH: AT1G43245 AT2G17900(SDG37) AT2G19640(ASHR2) AT3G03750(SDG20) AT5G06620(SDG38)
LJA: Lj0g3v0111689.1(Lj0g3v0111689.1) Lj0g3v0111689.2(Lj0g3v0111689.2) Lj0g3v0172449.1(Lj0g3v0172449.1) Lj0g3v0172449.2(Lj0g3v0172449.2) Lj0g3v0252639.1(Lj0g3v0252639.1) Lj0g3v0252639.2(Lj0g3v0252639.2) Lj1g3v0764540.1(Lj1g3v0764540.1) Lj1g3v0764540.2(Lj1g3v0764540.2) Lj2g3v1436870.1(Lj2g3v1436870.1) Lj4g3v0165060.1(Lj4g3v0165060.1) Lj4g3v0166140.1(Lj4g3v0166140.1)
DOSA: Os01t0772150-00(Os01g0772150) Os03t0704200-01(Os03g0704200) Os04t0423600-01(Os04g0423600) Os08t0205300-01(Os08g0205300) Os10t0410700-01(Os10g0410700)
ATS: 109736395(LOC109736395) 109736528(LOC109736528) 109741969(LOC109741969) 109747984(LOC109747984) 109776439(LOC109776439)
OLU: OSTLU_15174(SDG3512) OSTLU_92854(SDG3513)
ERC: Ecym_2380
KMX: KLMA_30450(SET6)
NCS: NCAS_0C01270(NCAS0C01270)
NDI: NDAI_0K01280(NDAI0K01280)
TDL: TDEL_0A06370(TDEL0A06370)
KAF: KAFR_0H02340(KAFR0H02340)
CAL: CAALFM_C102080WA(SET6)
SLB: AWJ20_424(SET6)
NCR: NCU02962
NTE: NEUTE1DRAFT150707(NEUTE1DRAFT_150707)
MGR: MGG_15522
NHE: NECHADRAFT_74600(SDG2107)
MAW: MAC_04196
MAJ: MAA_03895
CMT: CCM_06809
MBE: MBM_00175
ANI: AN5998.2
ANG: ANI_1_1754144(An16g04950)
PBN: PADG_11427(PADG_02444)
ABE: ARB_06461
TVE: TRV_07081
SPO: SPBP8B7.07c(set6)
CNE: CNH00900
CNB: CNBL0850
ABP: AGABI1DRAFT102088(AGABI1DRAFT_102088) AGABI1DRAFT120631(AGABI1DRAFT_120631) AGABI1DRAFT76762(AGABI1DRAFT_76762)
ABV: AGABI2DRAFT120820(AGABI2DRAFT_120820) AGABI2DRAFT211045(AGABI2DRAFT_211045) AGABI2DRAFT223832(AGABI2DRAFT_223832)
MGL: MGL_3610
MRT: MRET_0402
EHI: EHI_092690(175.t00011)
PYO: PY17X_1133200(PY04885)
PCB: PCHAS_113130(PC000913.02.0)
CPV: cgd7_5090
SMIN: v1.2.019699.t1(symbB.v1.2.019699.t1) v1.2.029529.t3(symbB.v1.2.029529.t3) v1.2.035053.t1(symbB.v1.2.035053.t1)
 » show all
Taxonomy
Reference
1  [PMID:21187428]
  Authors
Fnu S, Williamson EA, De Haro LP, Brenneman M, Wray J, Shaheen M, Radhakrishnan K, Lee SH, Nickoloff JA, Hromas R
  Title
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.
  Journal
Proc Natl Acad Sci U S A 108:540-5 (2011)
  Sequence
[hsa:6419]
Reference
2  [PMID:22099308]
  Authors
Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O
  Title
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
  Journal
Mol Cell 44:609-20 (2011)
  Sequence
[hsa:7468]
Reference
3  [PMID:21196496]
  Authors
Qiao Q, Li Y, Chen Z, Wang M, Reinberg D, Xu RM
  Title
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation.
  Journal
J Biol Chem 286:8361-8 (2011)
DOI:10.1074/jbc.M110.204115
  Sequence
[hsa:64324]
Reference
4  [PMID:22266761]
  Authors
Wagner EJ, Carpenter PB
  Title
Understanding the language of Lys36 methylation at histone H3.
  Journal
Nat Rev Mol Cell Biol 13:115-26 (2012)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.357
IUBMB Enzyme Nomenclature: 2.1.1.357
ExPASy - ENZYME nomenclature database: 2.1.1.357
BRENDA, the Enzyme Database: 2.1.1.357

KEGG   ENZYME: 2.1.1.359Help
Entry
EC 2.1.1.359                Enzyme                                 

Name
[histone H3]-lysine36 N-trimethyltransferase;
SET2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36
Comment
The enzyme, characterized from yeast, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. In mammals this activity is catalysed by two different enzymes, EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase and EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase.
History
EC 2.1.1.359 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.359
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K23700  [histone H3]-lysine36 N-trimethyltransferase
Genes
QSU: 112010221 112037919
SCE: YJL168C(SET2)
AGO: AGOS_AEL128C
ERC: Ecym_8108
KLA: KLLA0_A06600g
KMX: KLMA_10383(SET2)
LTH: KLTH0F04510g
VPO: Kpol_2001p35
ZRO: ZYRO0G18766g
CGR: CAGL0C00297g
NCS: NCAS_0I02880(NCAS0I02880)
NDI: NDAI_0B00260(NDAI0B00260)
TPF: TPHA_0A02720(TPHA0A02720)
TBL: TBLA_0J01040(TBLA0J01040)
TDL: TDEL_0G02090(TDEL0G02090)
KAF: KAFR_0F01770(KAFR0F01770)
CAL: CAALFM_C210250CA(SET2)
SLB: AWJ20_4803(SET2)
NCR: NCU00269(set-2)
NTE: NEUTE1DRAFT122301(NEUTE1DRAFT_122301)
MGR: MGG_01661
SSCK: SPSK_04901
NHE: NECHADRAFT_106311(SDG2102)
MAW: MAC_05010
MAJ: MAA_03512
CMT: CCM_07296
BFU: BCIN_10g05250(Bcset2)
MBE: MBM_00950
ANI: AN8825.2
ANG: ANI_1_490154(An17g01825)
ABE: ARB_07003
TVE: TRV_02085
PTE: PTT_20031
ZTR: MYCGRDRAFT_20674(SDG2404)
NPA: UCRNP2_87
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SPO: SPAC29B12.02c(set2)