KEGG   PATHWAY: hsa04144
Entry
hsa04144                    Pathway                                
Name
Endocytosis - Homo sapiens (human)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
hsa04144  Endocytosis
hsa04144

Drug
D03058  Basiliximab (USAN/INN)
D03210  Ancriviroc (USAN/INN)
D03639  Daclizumab (USAN/INN)
D03682  Denileukin diftitox (USAN/INN)
D06297  Vicriviroc maleate (USAN)
D06557  Aplaviroc hydrochloride (USAN)
D06670  Maraviroc (JAN/INN)
D09878  Cenicriviroc (USAN/INN)
D09879  Cenicriviroc mesylate (USAN)
D10434  Vintafolide (USAN/INN)
D10954  Mirvetuximab soravtansine (USAN/INN)
D11399  Leronlimab (USAN/INN)
D11812  Pabinafusp alfa (genetical recombination) (JAN)
D12183  Farletuzumab ecteribulin (USAN)
D12249  Pafolacianine (USAN/INN)
D12250  Pafolacianine sodium (USAN)
D12509  Trontinemab (USAN/INN)
D12556  Eltrekibart (USAN)
D12768  Ficerafusp alfa (USAN)
D12806  Tividenofusp alfa (USAN/INN)
D12880  Pasifolate exatecan (USAN)
D12928  Vopikitug (USAN/INN)
D12952  Veligrotug (USAN/INN)
Other DBs
GO: 0006897
Organism
Homo sapiens (human) [GN:hsa]
Gene
10015  PDCD6IP; programmed cell death 6 interacting protein [KO:K12200]
100287171  WASHC1; WASH complex subunit 1 [KO:K18461]
100526767  RNF103-CHMP3; RNF103-CHMP3 readthrough [KO:K12193]
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10096  ACTR3; actin related protein 3 [KO:K18584]
10097  ACTR2; actin related protein 2 [KO:K17260]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10193  RNF41; ring finger protein 41 [KO:K11981] [EC:2.3.2.27]
10254  STAM2; signal transducing adaptor molecule 2 [KO:K04705]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10564  ARFGEF2; ADP ribosylation factor guanine nucleotide exchange factor 2 [KO:K18442]
10565  ARFGEF1; ADP ribosylation factor guanine nucleotide exchange factor 1 [KO:K18442]
10617  STAMBP; STAM binding protein [KO:K11866] [EC:3.4.19.12]
10890  RAB10; RAB10, member RAS oncogene family [KO:K07903]
10938  EHD1; EH domain containing 1 [KO:K12483]
11021  RAB35; RAB35, member RAS oncogene family [KO:K07876]
11031  RAB31; RAB31, member RAS oncogene family [KO:K07891]
11059  WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:2.3.2.26]
11267  SNF8; SNF8 subunit of ESCRT-II [KO:K12188]
112936  VPS26B; VPS26 retromer complex component B [KO:K18466]
11311  VPS45; vacuolar protein sorting 45 homolog [KO:K12479]
116983  ACAP3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
116984  ARAP2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K18440]
116985  ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K18439]
116986  AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848]
116987  AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
116988  AGAP3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
1173  AP2M1; adaptor related protein complex 2 subunit mu 1 [KO:K11826]
1175  AP2S1; adaptor related protein complex 2 subunit sigma 1 [KO:K11827]
118813  ZFYVE27; zinc finger FYVE-type containing 27 [KO:K19368]
119016  AGAP4; ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 [KO:K12491]
1211  CLTA; clathrin light chain A [KO:K04644]
1212  CLTB; clathrin light chain B [KO:K04645]
1213  CLTC; clathrin heavy chain [KO:K04646]
1234  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
124908094  [KO:K18461]
124908102  WASH; WAS protein family homolog 2-like [KO:K18461]
128866  CHMP4B; charged multivesicular body protein 4B [KO:K12194]
131890  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
137492  VPS37A; VPS37A subunit of ESCRT-I [KO:K12185]
138429  PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase like 1 [KO:K13712] [EC:2.7.1.68]
147179  WIPF2; WAS/WASL interacting protein family member 2 [KO:K19475]
155382  VPS37D; VPS37D subunit of ESCRT-I [KO:K12185]
156  GRK2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
157  GRK3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
160  AP2A1; adaptor related protein complex 2 subunit alpha 1 [KO:K11824]
1601  DAB2; DAB adaptor protein 2 [KO:K12475]
161  AP2A2; adaptor related protein complex 2 subunit alpha 2 [KO:K11824]
163  AP2B1; adaptor related protein complex 2 subunit beta 1 [KO:K11825]
1759  DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785  DNM2; dynamin 2 [KO:K23484]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2060  EPS15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
2261  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2263  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2264  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
22841  RAB11FIP2; RAB11 family interacting protein 2 [KO:K12484]
22905  EPN2; epsin 2 [KO:K12471]
23096  IQSEC2; IQ motif and Sec7 domain ArfGEF 2 [KO:K12495]
23111  SPART; spartin [KO:K19366]
23325  WASHC4; WASH complex subunit 4 [KO:K18465]
23327  NEDD4L; NEDD4 like E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
23362  PSD3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
23396  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
2348  FOLR1; folate receptor alpha [KO:K13649]
2350  FOLR2; folate receptor beta [KO:K13649]
2352  FOLR3; folate receptor gamma [KO:K13649]
23527  ACAP2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
23550  PSD4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
23624  CBLC; Cbl proto-oncogene C [KO:K22518] [EC:2.3.2.27]
253725  WASHC2C; WASH complex subunit 2C [KO:K18462]
254122  SNX32; sorting nexin 32 [KO:K17920]
25978  CHMP2B; charged multivesicular body protein 2B [KO:K12192]
26052  DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
26056  RAB11FIP5; RAB11 family interacting protein 5 [KO:K12484]
26119  LDLRAP1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
26286  ARFGAP3; ADP ribosylation factor GTPase activating protein 3 [KO:K12493]
27128  CYTH4; cytohesin 4 [KO:K18441]
27131  SNX5; sorting nexin 5 [KO:K17920]
27183  VPS4A; vacuolar protein sorting 4 homolog A [KO:K12196]
27243  CHMP2A; charged multivesicular body protein 2A [KO:K12191]
273  AMPH; amphiphysin [KO:K12562]
274  BIN1; bridging integrator 1 [KO:K12562]
2868  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
2869  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
2870  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
28964  GIT1; GIT ArfGAP 1 [KO:K05737]
29082  CHMP4A; charged multivesicular body protein 4A [KO:K12194]
29924  EPN1; epsin 1 [KO:K12471]
29934  SNX12; sorting nexin 12 [KO:K17918]
30011  SH3KBP1; SH3 domain containing kinase binding protein 1 [KO:K12470]
30844  EHD4; EH domain containing 4 [KO:K12477]
30845  EHD3; EH domain containing 3 [KO:K12476]
30846  EHD2; EH domain containing 2 [KO:K12469]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3303  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
3304  HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
3305  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
3310  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
3312  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
3480  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
3482  IGF2R; insulin like growth factor 2 receptor [KO:K06564]
3559  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3560  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
3577  CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
3579  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
375  ARF1; ADP ribosylation factor 1 [KO:K07937]
377  ARF3; ADP ribosylation factor 3 [KO:K07938]
378  ARF4; ADP ribosylation factor 4 [KO:K07939]
3798  KIF5A; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
3799  KIF5B; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
3800  KIF5C; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
381  ARF5; ADP ribosylation factor 5 [KO:K07940]
382  ARF6; ADP ribosylation factor 6 [KO:K07941]
387  RHOA; ras homolog family member A [KO:K04513]
387680  WASHC2A; WASH complex subunit 2A [KO:K18462]
3949  LDLR; low density lipoprotein receptor [KO:K12473]
408  ARRB1; arrestin beta 1 [KO:K04439]
4087  SMAD2; SMAD family member 2 [KO:K04500]
4088  SMAD3; SMAD family member 3 [KO:K23605]
409  ARRB2; arrestin beta 2 [KO:K04439]
414189  AGAP6; ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 [KO:K12491]
4193  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
4218  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
440073  IQSEC3; IQ motif and Sec7 domain ArfGEF 3 [KO:K12495]
4734  NEDD4; NEDD4 E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
50807  ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
50855  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
51019  WASHC3; WASH complex subunit 3 [KO:K18463]
51028  VPS36; vacuolar protein sorting 36 homolog [KO:K12190]
51100  SH3GLB1; SH3 domain containing GRB2 like, endophilin B1 [KO:K11248]
51160  VPS28; VPS28 subunit of ESCRT-I [KO:K12184]
5119  CHMP1A; charged multivesicular body protein 1A [KO:K12197]
51324  SPG21; SPG21 abhydrolase domain containing, maspardin [KO:K19367]
51510  CHMP5; charged multivesicular body protein 5 [KO:K12198]
51534  VTA1; vesicle trafficking 1 [KO:K12199]
5156  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
51652  CHMP3; charged multivesicular body protein 3 [KO:K12193]
51699  VPS29; VPS29 retromer complex component [KO:K18467]
5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
5371  PML; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
55040  EPN3; epsin 3 [KO:K12471]
55048  VPS37C; VPS37C subunit of ESCRT-I [KO:K12185]
55616  ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
55680  RUFY2; RUN and FYVE domain containing 2 [KO:K12482]
55737  VPS35; VPS35 retromer complex component [KO:K18468]
55738  ARFGAP1; ADP ribosylation factor GTPase activating protein 1 [KO:K12492]
5584  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
5590  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
56288  PARD3; par-3 family cell polarity regulator [KO:K04237]
5662  PSD; pleckstrin and Sec7 domain containing [KO:K12494]
56904  SH3GLB2; SH3 domain containing GRB2 like, endophilin B2 [KO:K21269]
57132  CHMP1B; charged multivesicular body protein 1B [KO:K12197]
57154  SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:2.3.2.26]
57180  ACTR3B; actin related protein 3B [KO:K18584]
57403  RAB22A; RAB22A, member RAS oncogene family [KO:K07891]
58513  EPS15L1; epidermal growth factor receptor pathway substrate 15 like 1 [KO:K12472]
58533  SNX6; sorting nexin 6 [KO:K17920]
5867  RAB4A; RAB4A, member RAS oncogene family [KO:K07879]
5868  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
6011  GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
60682  SMAP1; small ArfGAP 1 [KO:K12486]
64145  RBSN; rabenosyn, RAB effector [KO:K12481]
642517  AGAP9; ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 [KO:K12491]
64411  ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
644150  WIPF3; WAS/WASL interacting protein family member 3 [KO:K19475]
6455  SH3GL1; SH3 domain containing GRB2 like 1, endophilin A2 [KO:K11247]
6456  SH3GL2; SH3 domain containing GRB2 like 2, endophilin A1 [KO:K11247]
6457  SH3GL3; SH3 domain containing GRB2 like 3, endophilin A3 [KO:K11247]
64744  SMAP2; small ArfGAP2 [KO:K12486]
64750  SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:2.3.2.26]
653857  ACTR3C; actin related protein 3C [KO:K18584]
6642  SNX1; sorting nexin 1 [KO:K17917]
6643  SNX2; sorting nexin 2 [KO:K17917]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
7037  TFRC; transferrin receptor [KO:K06503]
7046  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
7251  TSG101; tumor susceptibility 101 [KO:K12183]
729092  AGAP5; ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 [KO:K12491]
7456  WIPF1; WAS/WASL interacting protein family member 1 [KO:K19475]
7852  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
7879  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
79643  CHMP6; charged multivesicular body protein 6 [KO:K12195]
79720  VPS37B; VPS37B subunit of ESCRT-I [KO:K12185]
80223  RAB11FIP1; RAB11 family interacting protein 1 [KO:K12484]
80230  RUFY1; RUN and FYVE domain containing 1 [KO:K12482]
8027  STAM; signal transducing adaptor molecule [KO:K04705]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
8218  CLTCL1; clathrin heavy chain like 1 [KO:K04646]
829  CAPZA1; capping actin protein of muscle Z-line subunit alpha 1 [KO:K10364]
830  CAPZA2; capping actin protein of muscle Z-line subunit alpha 2 [KO:K10364]
832  CAPZB; capping actin protein of muscle Z-line subunit beta [KO:K10365]
83737  ITCH; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:2.3.2.26]
8394  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
8411  EEA1; early endosome antigen 1 [KO:K12478]
84249  PSD2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
84313  VPS25; vacuolar protein sorting 25 homolog [KO:K12189]
84364  ARFGAP2; ADP ribosylation factor GTPase activating protein 2 [KO:K12493]
84440  RAB11FIP4; RAB11 family interacting protein 4 [KO:K12485]
84552  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
84612  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
857  CAV1; caveolin 1 [KO:K06278]
858  CAV2; caveolin 2 [KO:K12958]
859  CAV3; caveolin 3 [KO:K12959]
867  CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
868  CBLB; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
8723  SNX4; sorting nexin 4 [KO:K17919]
8724  SNX3; sorting nexin 3 [KO:K17918]
8729  GBF1; golgi brefeldin A resistant guanine nucleotide exchange factor 1 [KO:K18443]
8766  RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
8853  ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
8976  WASL; WASP like actin nucleation promoting factor [KO:K23612]
89853  MVB12B; multivesicular body subunit 12B [KO:K12186]
9101  USP8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.4.19.12]
9135  RABEP1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
9146  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
91782  CHMP7; charged multivesicular body protein 7 [KO:K15053]
9230  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
92421  CHMP4C; charged multivesicular body protein 4C [KO:K24782]
9265  CYTH3; cytohesin 3 [KO:K18441]
9266  CYTH2; cytohesin 2 [KO:K18441]
9267  CYTH1; cytohesin 1 [KO:K18441]
93343  MVB12A; multivesicular body subunit 12A [KO:K12186]
93661  CAPZA3; capping actin protein of muscle Z-line subunit alpha 3 [KO:K10364]
9372  ZFYVE9; zinc finger FYVE-type containing 9 [KO:K04679]
9525  VPS4B; vacuolar protein sorting 4 homolog B [KO:K12196]
9559  VPS26A; VPS26 retromer complex component A [KO:K18466]
9727  RAB11FIP3; RAB11 family interacting protein 3 [KO:K12485]
9744  ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
9765  ZFYVE16; zinc finger FYVE-type containing 16 [KO:K04679]
9798  IST1; IST1 factor associated with ESCRT-III [KO:K19476]
9815  GIT2; GIT ArfGAP 2 [KO:K12487]
9829  DNAJC6; DnaJ heat shock protein family (Hsp40) member C6 [KO:K09526]
9897  WASHC5; WASH complex subunit 5 [KO:K18464]
9922  IQSEC1; IQ motif and Sec7 domain ArfGEF 1 [KO:K12495]
998  CDC42; cell division cycle 42 [KO:K04393]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04070  Phosphatidylinositol signaling system
hsa04130  SNARE interactions in vesicular transport
hsa04142  Lysosome
hsa04350  TGF-beta signaling pathway
KO pathway
ko04144   

  All links  
No link information was found.
KEGG   PATHWAY: hsa04144
Entry
hsa04144                    Pathway                                
Name
Endocytosis - Homo sapiens (human)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
hsa04144  Endocytosis
hsa04144

Drug
D03058  Basiliximab (USAN/INN)
D03210  Ancriviroc (USAN/INN)
D03639  Daclizumab (USAN/INN)
D03682  Denileukin diftitox (USAN/INN)
D06297  Vicriviroc maleate (USAN)
D06557  Aplaviroc hydrochloride (USAN)
D06670  Maraviroc (JAN/INN)
D09878  Cenicriviroc (USAN/INN)
D09879  Cenicriviroc mesylate (USAN)
D10434  Vintafolide (USAN/INN)
D10954  Mirvetuximab soravtansine (USAN/INN)
D11399  Leronlimab (USAN/INN)
D11812  Pabinafusp alfa (genetical recombination) (JAN)
D12183  Farletuzumab ecteribulin (USAN)
D12249  Pafolacianine (USAN/INN)
D12250  Pafolacianine sodium (USAN)
D12509  Trontinemab (USAN/INN)
D12556  Eltrekibart (USAN)
D12768  Ficerafusp alfa (USAN)
D12806  Tividenofusp alfa (USAN/INN)
D12880  Pasifolate exatecan (USAN)
D12928  Vopikitug (USAN/INN)
D12952  Veligrotug (USAN/INN)
Other DBs
GO: 0006897
Organism
Homo sapiens (human) [GN:hsa]
Gene
10015  PDCD6IP; programmed cell death 6 interacting protein [KO:K12200]
100287171  WASHC1; WASH complex subunit 1 [KO:K18461]
100526767  RNF103-CHMP3; RNF103-CHMP3 readthrough [KO:K12193]
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10096  ACTR3; actin related protein 3 [KO:K18584]
10097  ACTR2; actin related protein 2 [KO:K17260]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10193  RNF41; ring finger protein 41 [KO:K11981] [EC:2.3.2.27]
10254  STAM2; signal transducing adaptor molecule 2 [KO:K04705]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10564  ARFGEF2; ADP ribosylation factor guanine nucleotide exchange factor 2 [KO:K18442]
10565  ARFGEF1; ADP ribosylation factor guanine nucleotide exchange factor 1 [KO:K18442]
10617  STAMBP; STAM binding protein [KO:K11866] [EC:3.4.19.12]
10890  RAB10; RAB10, member RAS oncogene family [KO:K07903]
10938  EHD1; EH domain containing 1 [KO:K12483]
11021  RAB35; RAB35, member RAS oncogene family [KO:K07876]
11031  RAB31; RAB31, member RAS oncogene family [KO:K07891]
11059  WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:2.3.2.26]
11267  SNF8; SNF8 subunit of ESCRT-II [KO:K12188]
112936  VPS26B; VPS26 retromer complex component B [KO:K18466]
11311  VPS45; vacuolar protein sorting 45 homolog [KO:K12479]
116983  ACAP3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
116984  ARAP2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K18440]
116985  ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K18439]
116986  AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848]
116987  AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
116988  AGAP3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
1173  AP2M1; adaptor related protein complex 2 subunit mu 1 [KO:K11826]
1175  AP2S1; adaptor related protein complex 2 subunit sigma 1 [KO:K11827]
118813  ZFYVE27; zinc finger FYVE-type containing 27 [KO:K19368]
119016  AGAP4; ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 [KO:K12491]
1211  CLTA; clathrin light chain A [KO:K04644]
1212  CLTB; clathrin light chain B [KO:K04645]
1213  CLTC; clathrin heavy chain [KO:K04646]
1234  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
124908094  [KO:K18461]
124908102  WASH; WAS protein family homolog 2-like [KO:K18461]
128866  CHMP4B; charged multivesicular body protein 4B [KO:K12194]
131890  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
137492  VPS37A; VPS37A subunit of ESCRT-I [KO:K12185]
138429  PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase like 1 [KO:K13712] [EC:2.7.1.68]
147179  WIPF2; WAS/WASL interacting protein family member 2 [KO:K19475]
155382  VPS37D; VPS37D subunit of ESCRT-I [KO:K12185]
156  GRK2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
157  GRK3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
160  AP2A1; adaptor related protein complex 2 subunit alpha 1 [KO:K11824]
1601  DAB2; DAB adaptor protein 2 [KO:K12475]
161  AP2A2; adaptor related protein complex 2 subunit alpha 2 [KO:K11824]
163  AP2B1; adaptor related protein complex 2 subunit beta 1 [KO:K11825]
1759  DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785  DNM2; dynamin 2 [KO:K23484]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2060  EPS15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
2261  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2263  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2264  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
22841  RAB11FIP2; RAB11 family interacting protein 2 [KO:K12484]
22905  EPN2; epsin 2 [KO:K12471]
23096  IQSEC2; IQ motif and Sec7 domain ArfGEF 2 [KO:K12495]
23111  SPART; spartin [KO:K19366]
23325  WASHC4; WASH complex subunit 4 [KO:K18465]
23327  NEDD4L; NEDD4 like E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
23362  PSD3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
23396  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
2348  FOLR1; folate receptor alpha [KO:K13649]
2350  FOLR2; folate receptor beta [KO:K13649]
2352  FOLR3; folate receptor gamma [KO:K13649]
23527  ACAP2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
23550  PSD4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
23624  CBLC; Cbl proto-oncogene C [KO:K22518] [EC:2.3.2.27]
253725  WASHC2C; WASH complex subunit 2C [KO:K18462]
254122  SNX32; sorting nexin 32 [KO:K17920]
25978  CHMP2B; charged multivesicular body protein 2B [KO:K12192]
26052  DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
26056  RAB11FIP5; RAB11 family interacting protein 5 [KO:K12484]
26119  LDLRAP1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
26286  ARFGAP3; ADP ribosylation factor GTPase activating protein 3 [KO:K12493]
27128  CYTH4; cytohesin 4 [KO:K18441]
27131  SNX5; sorting nexin 5 [KO:K17920]
27183  VPS4A; vacuolar protein sorting 4 homolog A [KO:K12196]
27243  CHMP2A; charged multivesicular body protein 2A [KO:K12191]
273  AMPH; amphiphysin [KO:K12562]
274  BIN1; bridging integrator 1 [KO:K12562]
2868  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
2869  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
2870  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
28964  GIT1; GIT ArfGAP 1 [KO:K05737]
29082  CHMP4A; charged multivesicular body protein 4A [KO:K12194]
29924  EPN1; epsin 1 [KO:K12471]
29934  SNX12; sorting nexin 12 [KO:K17918]
30011  SH3KBP1; SH3 domain containing kinase binding protein 1 [KO:K12470]
30844  EHD4; EH domain containing 4 [KO:K12477]
30845  EHD3; EH domain containing 3 [KO:K12476]
30846  EHD2; EH domain containing 2 [KO:K12469]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3303  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
3304  HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
3305  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
3310  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
3312  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
3480  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
3482  IGF2R; insulin like growth factor 2 receptor [KO:K06564]
3559  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3560  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
3577  CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
3579  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
375  ARF1; ADP ribosylation factor 1 [KO:K07937]
377  ARF3; ADP ribosylation factor 3 [KO:K07938]
378  ARF4; ADP ribosylation factor 4 [KO:K07939]
3798  KIF5A; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
3799  KIF5B; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
3800  KIF5C; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
381  ARF5; ADP ribosylation factor 5 [KO:K07940]
382  ARF6; ADP ribosylation factor 6 [KO:K07941]
387  RHOA; ras homolog family member A [KO:K04513]
387680  WASHC2A; WASH complex subunit 2A [KO:K18462]
3949  LDLR; low density lipoprotein receptor [KO:K12473]
408  ARRB1; arrestin beta 1 [KO:K04439]
4087  SMAD2; SMAD family member 2 [KO:K04500]
4088  SMAD3; SMAD family member 3 [KO:K23605]
409  ARRB2; arrestin beta 2 [KO:K04439]
414189  AGAP6; ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 [KO:K12491]
4193  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
4218  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
440073  IQSEC3; IQ motif and Sec7 domain ArfGEF 3 [KO:K12495]
4734  NEDD4; NEDD4 E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
50807  ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
50855  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
51019  WASHC3; WASH complex subunit 3 [KO:K18463]
51028  VPS36; vacuolar protein sorting 36 homolog [KO:K12190]
51100  SH3GLB1; SH3 domain containing GRB2 like, endophilin B1 [KO:K11248]
51160  VPS28; VPS28 subunit of ESCRT-I [KO:K12184]
5119  CHMP1A; charged multivesicular body protein 1A [KO:K12197]
51324  SPG21; SPG21 abhydrolase domain containing, maspardin [KO:K19367]
51510  CHMP5; charged multivesicular body protein 5 [KO:K12198]
51534  VTA1; vesicle trafficking 1 [KO:K12199]
5156  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
51652  CHMP3; charged multivesicular body protein 3 [KO:K12193]
51699  VPS29; VPS29 retromer complex component [KO:K18467]
5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
5371  PML; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
55040  EPN3; epsin 3 [KO:K12471]
55048  VPS37C; VPS37C subunit of ESCRT-I [KO:K12185]
55616  ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
55680  RUFY2; RUN and FYVE domain containing 2 [KO:K12482]
55737  VPS35; VPS35 retromer complex component [KO:K18468]
55738  ARFGAP1; ADP ribosylation factor GTPase activating protein 1 [KO:K12492]
5584  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
5590  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
56288  PARD3; par-3 family cell polarity regulator [KO:K04237]
5662  PSD; pleckstrin and Sec7 domain containing [KO:K12494]
56904  SH3GLB2; SH3 domain containing GRB2 like, endophilin B2 [KO:K21269]
57132  CHMP1B; charged multivesicular body protein 1B [KO:K12197]
57154  SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:2.3.2.26]
57180  ACTR3B; actin related protein 3B [KO:K18584]
57403  RAB22A; RAB22A, member RAS oncogene family [KO:K07891]
58513  EPS15L1; epidermal growth factor receptor pathway substrate 15 like 1 [KO:K12472]
58533  SNX6; sorting nexin 6 [KO:K17920]
5867  RAB4A; RAB4A, member RAS oncogene family [KO:K07879]
5868  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
6011  GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
60682  SMAP1; small ArfGAP 1 [KO:K12486]
64145  RBSN; rabenosyn, RAB effector [KO:K12481]
642517  AGAP9; ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 [KO:K12491]
64411  ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
644150  WIPF3; WAS/WASL interacting protein family member 3 [KO:K19475]
6455  SH3GL1; SH3 domain containing GRB2 like 1, endophilin A2 [KO:K11247]
6456  SH3GL2; SH3 domain containing GRB2 like 2, endophilin A1 [KO:K11247]
6457  SH3GL3; SH3 domain containing GRB2 like 3, endophilin A3 [KO:K11247]
64744  SMAP2; small ArfGAP2 [KO:K12486]
64750  SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:2.3.2.26]
653857  ACTR3C; actin related protein 3C [KO:K18584]
6642  SNX1; sorting nexin 1 [KO:K17917]
6643  SNX2; sorting nexin 2 [KO:K17917]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
7037  TFRC; transferrin receptor [KO:K06503]
7046  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
7251  TSG101; tumor susceptibility 101 [KO:K12183]
729092  AGAP5; ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 [KO:K12491]
7456  WIPF1; WAS/WASL interacting protein family member 1 [KO:K19475]
7852  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
7879  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
79643  CHMP6; charged multivesicular body protein 6 [KO:K12195]
79720  VPS37B; VPS37B subunit of ESCRT-I [KO:K12185]
80223  RAB11FIP1; RAB11 family interacting protein 1 [KO:K12484]
80230  RUFY1; RUN and FYVE domain containing 1 [KO:K12482]
8027  STAM; signal transducing adaptor molecule [KO:K04705]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
8218  CLTCL1; clathrin heavy chain like 1 [KO:K04646]
829  CAPZA1; capping actin protein of muscle Z-line subunit alpha 1 [KO:K10364]
830  CAPZA2; capping actin protein of muscle Z-line subunit alpha 2 [KO:K10364]
832  CAPZB; capping actin protein of muscle Z-line subunit beta [KO:K10365]
83737  ITCH; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:2.3.2.26]
8394  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
8411  EEA1; early endosome antigen 1 [KO:K12478]
84249  PSD2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
84313  VPS25; vacuolar protein sorting 25 homolog [KO:K12189]
84364  ARFGAP2; ADP ribosylation factor GTPase activating protein 2 [KO:K12493]
84440  RAB11FIP4; RAB11 family interacting protein 4 [KO:K12485]
84552  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
84612  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
857  CAV1; caveolin 1 [KO:K06278]
858  CAV2; caveolin 2 [KO:K12958]
859  CAV3; caveolin 3 [KO:K12959]
867  CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
868  CBLB; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
8723  SNX4; sorting nexin 4 [KO:K17919]
8724  SNX3; sorting nexin 3 [KO:K17918]
8729  GBF1; golgi brefeldin A resistant guanine nucleotide exchange factor 1 [KO:K18443]
8766  RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
8853  ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
8976  WASL; WASP like actin nucleation promoting factor [KO:K23612]
89853  MVB12B; multivesicular body subunit 12B [KO:K12186]
9101  USP8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.4.19.12]
9135  RABEP1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
9146  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
91782  CHMP7; charged multivesicular body protein 7 [KO:K15053]
9230  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
92421  CHMP4C; charged multivesicular body protein 4C [KO:K24782]
9265  CYTH3; cytohesin 3 [KO:K18441]
9266  CYTH2; cytohesin 2 [KO:K18441]
9267  CYTH1; cytohesin 1 [KO:K18441]
93343  MVB12A; multivesicular body subunit 12A [KO:K12186]
93661  CAPZA3; capping actin protein of muscle Z-line subunit alpha 3 [KO:K10364]
9372  ZFYVE9; zinc finger FYVE-type containing 9 [KO:K04679]
9525  VPS4B; vacuolar protein sorting 4 homolog B [KO:K12196]
9559  VPS26A; VPS26 retromer complex component A [KO:K18466]
9727  RAB11FIP3; RAB11 family interacting protein 3 [KO:K12485]
9744  ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
9765  ZFYVE16; zinc finger FYVE-type containing 16 [KO:K04679]
9798  IST1; IST1 factor associated with ESCRT-III [KO:K19476]
9815  GIT2; GIT ArfGAP 2 [KO:K12487]
9829  DNAJC6; DnaJ heat shock protein family (Hsp40) member C6 [KO:K09526]
9897  WASHC5; WASH complex subunit 5 [KO:K18464]
9922  IQSEC1; IQ motif and Sec7 domain ArfGEF 1 [KO:K12495]
998  CDC42; cell division cycle 42 [KO:K04393]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04070  Phosphatidylinositol signaling system
hsa04130  SNARE interactions in vesicular transport
hsa04142  Lysosome
hsa04350  TGF-beta signaling pathway
KO pathway
ko04144   

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