KEGG   PATHWAY: cfa05203
Entry
cfa05203                    Pathway                                
Name
Viral carcinogenesis - Canis lupus familiaris (dog)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
cfa05203  Viral carcinogenesis
cfa05203

Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
485864  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
403735  HRAS; GTPase HRas isoform 1 [KO:K02833]
403871  KRAS; GTPase KRas isoform X1 [KO:K07827]
403872  NRAS; GTPase NRas [KO:K07828]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
607922  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
478806  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
474503  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
611934  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X2 [KO:K09048]
483636  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
491369  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
485046  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
612303  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
475266  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X5 [KO:K09047]
474855  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
476067  DDB1; DNA damage-binding protein 1 [KO:K10610]
475864  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
477237  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
607060  YWHAQ; 14-3-3 protein theta [KO:K16197]
479459  LOW QUALITY PROTEIN: 14-3-3 protein theta-like [KO:K16197]
100855903  14-3-3 protein zeta/delta-like isoform X3 [KO:K16197]
609669  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
480645  YWHAE; 14-3-3 protein epsilon isoform X2 [KO:K06630]
608573  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
100687866  YWHAH; 14-3-3 protein eta [KO:K16198]
489818  YWHAG; 14-3-3 protein gamma [KO:K16198]
442952  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
490967  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
490968  STAT5A; signal transducer and activator of transcription 5A isoform X2 [KO:K11223]
490969  STAT5B; signal transducer and activator of transcription 5B isoform X2 [KO:K11224]
403567  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
484583  HPN; serine protease hepsin isoform X2 [KO:K08665] [EC:3.4.21.106]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100856339  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
483729  RELA; transcription factor p65 isoform X2 [KO:K04735]
474606  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
486858  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
442859  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
403869  TP53; cellular tumor antigen p53 [KO:K04451]
484610  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
487057  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100855704  CDK2; cyclin-dependent kinase 2 isoform X3 [KO:K02206] [EC:2.7.11.22]
479219  EGR2; E3 SUMO-protein ligase EGR2 isoform X4 [KO:K12496]
486121  EGR3; early growth response protein 3 isoform X2 [KO:K12497]
606963  VDAC3; voltage-dependent anion-selective channel protein 3 isoform 1 [KO:K15041]
486728  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
477402  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
100855638  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
474890  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
480886  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
611397  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
403556  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
479975  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
483164  H2BC18; histone H2B type 2-F [KO:K11252]
608682  H2BC17; histone H2B type 1-C/E/F/G/I [KO:K11252]
611989  histone H2B type 2-E1 isoform X4 [KO:K11252]
492038  H2BW3; histone H2B-like [KO:K11252]
610067  late histone H2B.L4-like [KO:K11252]
488253  H2BC2; histone H2B type 1-A [KO:K11252]
483169  H2BC19; histone H2B type 2-E [KO:K11252]
611089  H2BC3; histone H2B type 1-B [KO:K11252]
478743  histone H2B type 1-C/E/F/G/I [KO:K11252]
483170  H2BC20; histone H2B type 2-E [KO:K11252]
488252  H2BC1; histone H2B type 1-A [KO:K11252]
488267  H2BC4; histone H2B type 1-C/E/F/G/I [KO:K11252]
488279  H2BC10; histone H2B 1/2-like isoform X1 [KO:K11252]
488290  H2BC12; histone H2B type 1-K [KO:K11252]
611465  H2BC13; histone H2B type 1-C/E/F/G/I [KO:K11252]
611482  H2BC14; histone H2B type 1-C/E/F/G/I [KO:K11252]
488288  H2BC11; histone H2B type 1-J [KO:K11252]
488303  H2BC15; histone H2B type 1-K [KO:K11252]
482202  H2BU1; histone H2B type 3-B [KO:K11252]
100856186  H2BC8; histone H2B type 1-C/E/F/G/I [KO:K11252]
100855574  H2BC21; histone H2B type 2-E [KO:K11252]
611113  H2BC25; late histone H2B.L4 [KO:K11252]
106558265  H2BC9; histone H2B type 1-C/E/F/G/I [KO:K11252]
106559817  H2BE1; histone H2B type 2-E1 [KO:K11252]
111094863  H2BW2; histone H2B.1-like [KO:K11252]
102156643  H2BC7; histone H2B type 1-K-like [KO:K11252]
100683643  H2BU2; histone H2B type 1-F/J/L-like [KO:K11252]
111092555  H2BL1; histone H2B subacrosomal variant-like [KO:K11252]
119864260  histone H2B type 2-E1-like [KO:K11252]
486670  H4-16; histone H4 [KO:K11254]
106558236  H4C9; histone H4 [KO:K11254]
488298  H4C11; histone H4-like isoform X2 [KO:K11254]
111093990  H4C2; histone H3.1 [KO:K11254]
100855588  H4C6; histone H4-like [KO:K11254]
115945199  H4C12; H4 clustered histone 12 [KO:K11254]
403523  BAX; apoptosis regulator BAX [KO:K02159]
483312  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
611262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
100856079  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
476209  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
611193  TBP; TATA-box-binding protein [KO:K03120]
611011  TBPL2; TATA box-binding protein-like 2 isoform X5 [KO:K03120]
479854  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [KO:K11838] [EC:3.4.19.12]
403693  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
485892  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X5 [KO:K06053]
479122  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
480405  SNW1; SNW domain-containing protein 1 [KO:K06063]
476881  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
478089  general transcription factor IIH subunit 2 [KO:K03142]
477446  GTF2H3; general transcription factor IIH subunit 3 isoform X2 [KO:K03143]
100685309  LOW QUALITY PROTEIN: general transcription factor IIH subunit 3-like [KO:K03143]
488002  GTF2E1; general transcription factor IIE subunit 1 isoform X2 [KO:K03136]
119864634  general transcription factor IIE subunit 1 [KO:K03136]
100855770  GTF2E2; transcription initiation factor IIE subunit beta isoform X1 [KO:K03137]
475204  SND1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
479866  CREBBP; CREB-binding protein isoform X8 [KO:K04498] [EC:2.3.1.48]
100684945  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
479960  GTF2B; transcription initiation factor IIB [KO:K03124]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
611782  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
608847  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
609920  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
477302  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
483845  CCNA2; cyclin-A2 [KO:K06627]
489228  SKP2; S-phase kinase-associated protein 2 isoform X5 [KO:K03875]
474827  MRPS18B; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
480673  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
490867  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
480019  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
610004  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
477886  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
484196  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
477929  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
479685  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
479010  UBE3A; ubiquitin-protein ligase E3A isoform X3 [KO:K10587] [EC:2.3.2.26]
488036  DLG1; disks large homolog 1 isoform X18 [KO:K12076]
100685037  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
486299  PXN; paxillin isoform X2 [KO:K05760]
481744  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
476412  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100688636  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
476915  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X5 [KO:K06618]
477221  RBL1; retinoblastoma-like protein 1 isoform X3 [KO:K04681]
478127  RBL2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
403429  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
478211  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X6 [KO:K10691] [EC:2.3.2.27]
609429  JUN; transcription factor AP-1 [KO:K04448]
477714  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X2 [KO:K11643] [EC:5.6.2.-]
487309  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
475035  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
478040  HDAC3; histone deacetylase 3 isoform X2 [KO:K11404] [EC:3.5.1.98]
607662  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
490941  HDAC5; histone deacetylase 5 isoform X2 [KO:K11406] [EC:3.5.1.98]
480907  HDAC6; histone deacetylase 6 isoform X4 [KO:K11407] [EC:3.5.1.98]
486589  HDAC7; histone deacetylase 7 isoform X3 [KO:K11408] [EC:3.5.1.98]
480957  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
482339  HDAC9; histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
607032  HDAC10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
484633  HDAC11; histone deacetylase 11 isoform X4 [KO:K11418] [EC:3.5.1.98]
403874  PKM; pyruvate kinase PKM isoform X8 [KO:K00873] [EC:2.7.1.40]
607899  IRF9; interferon regulatory factor 9 [KO:K04693]
479865  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X3 [KO:K09504]
477052  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
490971  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
613006  GTF2A1; transcription initiation factor IIA subunit 1 isoform X1 [KO:K03122]
100534007  GTF2A1L; TFIIA-alpha and beta-like factor [KO:K03122]
478327  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
612861  SRF; serum response factor [KO:K04378]
480291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
485692  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
119863888  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119866928  cell division control protein 42 homolog [KO:K04393]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
403954  RHOA; transforming protein RhoA [KO:K04513]
474819  GSN; gelsolin isoform X1 [KO:K05768]
475245  SCIN; adseverin isoform X1 [KO:K05768]
480369  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
484526  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
481131  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
612475  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
481563  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
609767  CHEK1; serine/threonine-protein kinase Chk1 isoform X8 [KO:K02216] [EC:2.7.11.1]
100855774  CDC20; cell division cycle protein 20 homolog [KO:K03363]
609673  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X5 [KO:K06679]
489717  VAC14; protein VAC14 homolog [KO:K15305]
477563  RANBP1; ran-specific GTPase-activating protein isoform X2 [KO:K15306]
494001  POLB; DNA polymerase beta isoform X2 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
119864198  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
403545  IL6ST; interleukin-6 receptor subunit beta precursor [KO:K05060]
484789  CCR5; C-C chemokine receptor type 5 [KO:K04180]
485600  CCR8; C-C chemokine receptor type 8 [KO:K04183]
448802  CCR3; C-C chemokine receptor type 3 [KO:K04178]
403541  CCR4; C-C chemokine receptor type 4 [KO:K04179]
490263  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
488473  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
483763  BAD; bcl2-associated agonist of cell death [KO:K02158]
100502558  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
476728  C3; complement C3 [KO:K03990]
474836  DLA88; MHC class I DLA-88 precursor [KO:K06751]
483594  DLA-79; MHC class Ib precursor [KO:K06751]
474838  DLA-64; MHC class I DLA-64 precursor [KO:K06751]
541592  DLA-12; MHC class I DLA-12 precursor [KO:K06751]
100685196  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
Reference
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McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
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Biochim Biophys Acta 1782:127-50 (2008)
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Reference
PMID:21102637
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Moore PS, Chang Y
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Why do viruses cause cancer? Highlights of the first century of human tumour virology.
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Nat Rev Cancer 10:878-89 (2010)
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PMID:19400863
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Kalland KH, Ke XS, Oyan AM
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APMIS 117:382-99 (2009)
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PMID:17979705
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  Title
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Curr Med Chem 14:2526-39 (2007)
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PMID:21084867
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Cancer Biol Ther 10:961-78 (2010)
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PMID:21152115
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Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
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Int J Biol Sci 6:730-55 (2010)
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PMID:19956178
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Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
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Oncogene 27 Suppl 2:S31-42 (2008)
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PMID:16459163
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Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
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J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
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Virus Res 92:131-40 (2003)
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Reference
PMID:21647825
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  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
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J Gastroenterol 46:974-90 (2011)
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Reference
PMID:21966251
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  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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Reference
PMID:19854353
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  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
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Adv Cancer Res 103:75-109 (2009)
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Reference
PMID:18251977
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Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
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Liver Int 28:175-88 (2008)
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Reference
PMID:9343405
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Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Reference
PMID:16039586
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Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
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Reference
PMID:21994562
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Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
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Viruses 1:630-46 (2009)
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Reference
PMID:11099494
  Authors
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  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
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J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
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Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
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J Biol Chem 273:33347-53 (1998)
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Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
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J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
cfa03022  Basal transcription factors
cfa03320  PPAR signaling pathway
cfa04010  MAPK signaling pathway
cfa04062  Chemokine signaling pathway
cfa04064  NF-kappa B signaling pathway
cfa04110  Cell cycle
cfa04115  p53 signaling pathway
cfa04142  Lysosome
cfa04151  PI3K-Akt signaling pathway
cfa04210  Apoptosis
cfa04630  JAK-STAT signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04810  Regulation of actin cytoskeleton
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05169  Epstein-Barr virus infection
KO pathway
ko05203   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (201)   
   KEGG GENES (201)   
All databases (202)   

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