Entry
Name
Lysosome - Rattus norvegicus (rat)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
100362547 Ap1g2; adaptor related protein complex 1 subunit gamma 2 [KO:K12391 ]
116455 Atp6v0a2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154 ]
170667 Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155 ]
171494 Ap1g1; AP-1 complex subunit gamma-1 isoform 1 [KO:K12391 ]
24944 Lamp2; lysosome-associated membrane glycoprotein 2 precursor [KO:K06528 ]
25055 Lipa; lysosomal acid lipase/cholesteryl ester hydrolase precursor [KO:K01052 ] [EC:3.1.1.13 ]
25151 Igf2r; cation-independent mannose-6-phosphate receptor precursor [KO:K06564 ]
25328 Lamp1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528 ]
25524 Psap; prosaposin isoform A preproprotein [KO:K12382 ]
25715 Slc11a2; natural resistance-associated macrophage protein 2 isoform 1 [KO:K21398 ]
25732 Acp5; tartrate-resistant acid phosphatase type 5 isoform 2 precursor [KO:K14379 ] [EC:3.1.3.2 ]
266732 Npc1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385 ]
282838 Gm2a; ganglioside GM2 activator precursor [KO:K12383 ]
286898 Npc2; NPC intracellular cholesterol transporter 2 precursor [KO:K13443 ]
287134 Gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma precursor [KO:K10087 ]
289720 Psapl1; proactivator polypeptide-like 1 precursor [KO:K12382 ]
29174 Ctsj; cathepsin J precursor [KO:K09599 ] [EC:3.4.22.-]
291969 Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146 ]
293455 Gga2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404 ]
293650 Tcirg1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154 ]
293676 Ctsw; cathepsin W precursor [KO:K08569 ] [EC:3.4.22.-]
296981 Atp6v0a4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154 ]
29757 Atp6v0a1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154 ]
297797 Atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144 ]
297932 Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146 ]
298451 Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661 ]
298875 Laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
300066 Gga1; ADP-ribosylation factor-binding protein GGA1 isoform 2 [KO:K12404 ]
302290 Ap3s1; AP-3 complex subunit sigma-1 isoform 1 [KO:K12399 ]
303631 Arsg; arylsulfatase G precursor [KO:K12381 ] [EC:3.1.6.-]
303801 Lamp3; lysosome-associated membrane glycoprotein 3 precursor [KO:K06562 ]
304344 Ap4m1; AP-4 complex subunit mu-1 isoform 1 [KO:K12402 ]
306128 Cln5; ceroid-lipofuscinosis neuronal protein 5 precursor [KO:K12390 ]
306720 Ctsm; cathepsin M precursor [KO:K09600 ] [EC:3.4.22.-]
310166 Cln5l1; ceroid-lipofuscinosis neuronal protein 5 homolog [KO:K12390 ]
312689 M6pr; cation-dependent mannose-6-phosphate receptor precursor [KO:K10089 ]
315047 Laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387 ]
316519 Slc11a1; natural resistance-associated macrophage protein 1 [KO:K12347 ]
360476 Nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125 ] [EC:3.1.4.45 ]
360658 Gga3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404 ]
360785 Ap1s1; adaptor-related protein complex 1, sigma 1 subunit [KO:K12394 ]
361063 Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform 1 [KO:K12305 ] [EC:3.6.1.6 ]
361939 Mfsd8; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
362865 Gnptab; N-acetylglucosamine-1-phosphate transferase subunits alpha and beta [KO:K08239 ] [EC:2.7.8.17 ]
498995 Ncoa7; nuclear receptor coactivator 7 isoform X3 [KO:K25442 ]
60575 Napsa; napsin-A precursor [KO:K08565 ] [EC:3.4.23.-]
63886 Abcb9; ABC-type oligopeptide transporter ABCB9 [KO:K05656 ]
65161 Litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
66031 Wdr7; WD repeat-containing protein 7 isoform 1 [KO:K24738 ]
79248 Abca2; ATP-binding cassette sub-family A member 2 [KO:K05642 ]
83615 Atp6ap1; V-type proton ATPase subunit S1 precursor [KO:K03662 ]
83689 Cd164; sialomucin core protein 24 precursor [KO:K06546 ]
89783 Laptm5; lysosomal-associated transmembrane protein 5 [KO:K12387 ]
Compound
Reference
Authors
Eskelinen EL, Tanaka Y, Saftig P
Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal
Reference
Authors
Neufeld EF
Title
Lysosomal storage diseases.
Journal
Reference
Authors
von Figura K, Hasilik A
Title
Lysosomal enzymes and their receptors.
Journal
Reference
Authors
Janvier K, Bonifacino JS
Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal
Reference
Authors
Vergarajauregui S, Puertollano R
Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal
Reference
Authors
Jaskolka MC, Winkley SR, Kane PM
Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal
Reference
Authors
Majdoul S, Compton AA
Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal
Related pathway
rno04130 SNARE interactions in vesicular transport
KO pathway