KEGG   PATHWAY: sma03410Help
Entry
sma03410                    Pathway                                

Name
Base excision repair - Streptomyces avermitilis
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
sma03410  Base excision repair
sma03410

Ortholog table
Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_2664  mutM1; putative formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
SAVERM_7289  mutM2; putative formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
SAVERM_2501  nei1; putative endonuclease VIII and DNA N-glycosylase with an AP lyase activity [KO:K05522] [EC:3.2.2.- 4.2.99.18]
SAVERM_5427  nei2; putative endonuclease VIII and DNA N-glycosylase with an AP lyase activity [KO:K05522] [EC:3.2.2.- 4.2.99.18]
SAVERM_4593  nth; putative endonuclease III [KO:K10773] [EC:4.2.99.18]
SAVERM_1934  alkA1; putative ADA-like regulatory protein [KO:K13529] [EC:3.2.2.21]
SAVERM_3121  tagA; putative DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
SAVERM_7076  mug; putative G/U mismatch-specific DNA glycosylase [KO:K03649] [EC:3.2.2.28]
SAVERM_6242  hypothetical protein [KO:K21929] [EC:3.2.2.27]
SAVERM_1527  ung1; putative uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
SAVERM_7011  ung2; putative uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
SAVERM_4707  mutY; putative A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.31]
SAVERM_6486  putative 3-methyladenine DNA glycosylase [KO:K03652] [EC:3.2.2.21]
SAVERM_3628  exoA; putative exodeoxyribonuclease [KO:K01142] [EC:3.1.11.2]
SAVERM_1966  xthA; putative exonuclease [KO:K01142] [EC:3.1.11.2]
SAVERM_6091  nfo; putative endonuclease IV [KO:K01151] [EC:3.1.21.2]
SAVERM_6227  polA1; putative DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SAVERM_4636  polA2; putative DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SAVERM_2748  ligA; putative DNA ligase [KO:K01972] [EC:6.5.1.2]
SAVERM_7136  ligB; putative DNA ligase [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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