KEGG   REACTION: R03875
Entry
R03875                      Reaction                               
Definition
Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
Equation
C02188 + C00019 <=> C05544 + C00021
Reaction class
RC00003  C00019_C00021
RC00060  C02188_C05544
Enzyme
2.1.1.59        2.1.1.60        2.1.1.354       2.1.1.355       
2.1.1.356       2.1.1.357       2.1.1.359       2.1.1.360       
2.1.1.361       2.1.1.364       2.1.1.367       2.1.1.368       
2.1.1.369       2.1.1.370       2.1.1.371       2.1.1.372
Pathway
rn00310  Lysine degradation
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.59
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.60
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.354
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.355
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.356
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.357
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.359
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.360
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.361
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.364
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.367
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.368
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.369
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.370
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.371
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.372
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
Orthology
K04462  [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
K11423  [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K11424  [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357]
K11425  [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371]
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357]
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
K11428  [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361]
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
K11431  [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364]
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355]
K11433  [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357]
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
K15588  [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357]
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355]
K18804  [cytochrome c]-lysine N-methyltransferase [EC:2.1.1.59]
K18826  calmodulin-lysine N-methyltransferase [EC:2.1.1.60]
K20795  [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361]
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]
K22410  [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367]
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3 [EC:2.1.1.354]
K23700  [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K24405  [histone H3]-lysine9 N-dimethyltransferase [EC:2.1.1.368]
K24406  [histone H3]-lysine27 N-methyltransferase [EC:2.1.1.369]
K24407  [histone H4]-lysine20 N-trimethyltransferase [EC:2.1.1.372]
Other DBs
RHEA: 51739

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (18)   
   KEGG ENZYME (16)   
   KEGG RCLASS (2)   
Gene (20911)   
   KEGG ORTHOLOGY (33)   
   KEGG GENES (20878)   
All databases (20938)   

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