#=GF ID   ApoNAT_membrane
#=GF AC   PF26365.1
#=GF DE   Apolipoprotein N-acyltransferase integral membrane domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   TED:Q9PNJ9_TED01
#=GF GA   27.00 27.00;
#=GF TC   86.20 85.00;
#=GF NC   21.40 21.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP   Domain
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the N-terminal integral membrane domain of
#=GF CC   the Apolipoprotein N-acyltransferase family. This domain
#=GF CC   contains seven transmembrane alpha helices. The Apolipoprotein
#=GF CC   N-acyltransferase family is responsible for catalyzing the
#=GF CC   phospholipid-dependent N-acylation of the N-terminal cysteine of
#=GF CC   apolipoproteins. This enzymatic activity represents the final
#=GF CC   step in the maturation of lipoproteins, a crucial process for
#=GF CC   their proper function. The proteins in this family contain a CN
#=GF CC   hydrolase domain at the C-terminus, specifically the
#=GF CC   Apolipoprotein N-acyltransferase subfamily. This function is
#=GF CC   essential for the structural and functional integrity of
#=GF CC   lipoproteins, which play a vital role in lipid transport and
#=GF CC   metabolism.
#=GF SQ   78
#=GS T1D0V7_9HELI/33-228       AC T1D0V7.1
#=GS V8C9B4_9HELI/61-239       AC V8C9B4.1
#=GS A0A377JNE6_9HELI/19-197   AC A0A377JNE6.1
#=GS A0A076FA87_9BACT/24-195   AC A0A076FA87.1
#=GS A7GZ86_CAMC5/23-197       AC A7GZ86.2
#=GS I2K4Y1_9BACT/1-155        AC I2K4Y1.1
#=GS A0A3G9HEK7_9BACT/10-181   AC A0A3G9HEK7.1
#=GS A0A2W6MU86_9HELI/30-204   AC A0A2W6MU86.1
#=GS A0A4Q0ZR49_9BACT/11-182   AC A0A4Q0ZR49.1
#=GS A0A6L5WJX3_9BACT/24-195   AC A0A6L5WJX3.1
#=GS B5Z9V3_HELPG/5-184        AC B5Z9V3.1
#=GS A0A3D8IAT8_9HELI/24-200   AC A0A3D8IAT8.1
#=GS A0A268U1V7_9HELI/90-257   AC A0A268U1V7.1
#=GS A0A6G5R329_9BACT/23-197   AC A0A6G5R329.1
#=GS A0A329ZGP1_9HELI/50-224   AC A0A329ZGP1.1
#=GS A0A1S6UAM6_9BACT/23-195   AC A0A1S6UAM6.1
#=GS A0A4Q0XPT8_9BACT/11-178   AC A0A4Q0XPT8.1
#=GS A0A6M0L085_9BACT/10-191   AC A0A6M0L085.1
#=GS V8CKL6_9HELI/55-241       AC V8CKL6.1
#=GS E0UPN9_SULAO/4-177        AC E0UPN9.1
#=GS A0A7L8V522_9BACT/22-194   AC A0A7L8V522.1
#=GS A0A3D8HSU7_9HELI/84-261   AC A0A3D8HSU7.1
#=GS A0A1X9SRF2_9BACT/23-194   AC A0A1X9SRF2.1
#=GS A0A091B238_9BACT/9-180    AC A0A091B238.1
#=GS A0A1I5N2Z2_9BACT/15-186   AC A0A1I5N2Z2.1
#=GS A0A347VT85_9HELI/130-297  AC A0A347VT85.1
#=GS A0A268TA81_9HELI/5-180    AC A0A268TA81.1
#=GS A0A2N1J6J8_9BACT/11-181   AC A0A2N1J6J8.1
#=GS A0A381DGQ8_9BACT/1-103    AC A0A381DGQ8.1
#=GS A0A099TY74_9HELI/132-301  AC A0A099TY74.1
#=GS E6X2X4_NITSE/1-197        AC E6X2X4.1
#=GS A0A292YCG5_9BACT/15-201   AC A0A292YCG5.1
#=GS T0KSN9_9BACT/15-186       AC T0KSN9.1
#=GS A0A5P8P229_9BACT/11-181   AC A0A5P8P229.1
#=GS A0A7U4M2L7_9BACT/13-207   AC A0A7U4M2L7.1
#=GS A0A975GCB6_9BACT/5-177    AC A0A975GCB6.1
#=GS A0A128EDR8_9BACT/1-161    AC A0A128EDR8.1
#=GS A0A1B8JA47_9HELI/83-265   AC A0A1B8JA47.1
#=GS A0A4Q0XYU3_9BACT/11-182   AC A0A4Q0XYU3.1
#=GS A0A222MXM3_9BACT/24-197   AC A0A222MXM3.1
#=GS A0A2A2GV91_9HELI/49-226   AC A0A2A2GV91.1
#=GS LNT_HELPY/5-184           AC O24982.1
#=GS A7I0M5_CAMHC/1-156        AC A7I0M5.1
#=GS A0A7S7M2N0_9BACT/1-172    AC A0A7S7M2N0.1
#=GS A0A363D426_9BACT/11-181   AC A0A363D426.1
#=GS C5ZXZ2_9HELI/12-185       AC C5ZXZ2.1
#=GS A0A3D8I019_9HELI/33-210   AC A0A3D8I019.1
#=GS A0A7M1LG25_9BACT/24-195   AC A0A7M1LG25.1
#=GS A0A7H9CIJ2_9BACT/22-189   AC A0A7H9CIJ2.1
#=GS F8KR23_HELBC/12-191       AC F8KR23.1
#=GS A0A4U8UEX7_9HELI/11-183   AC A0A4U8UEX7.1
#=GS A0A2P8R1Y2_9BACT/25-196   AC A0A2P8R1Y2.1
#=GS J1FBX3_9BACT/2-177        AC J1FBX3.1
#=GS A0A6G5QI48_9BACT/24-195   AC A0A6G5QI48.1
#=GS D5V282_ARCNC/11-182       AC D5V282.1
#=GS C8PJY0_9BACT/23-207       AC C8PJY0.1
#=GS LNT_CAMJE/24-198          AC Q9PNJ9.1
#=GS D3UIP7_HELM1/13-198       AC D3UIP7.1
#=GS C3XE46_9HELI/161-331      AC C3XE46.2
#=GS Q30Q77_SULDN/16-187       AC Q30Q77.1
#=GS A0A4U7BQC5_9BACT/24-197   AC A0A4U7BQC5.1
#=GS A0A3D8JBV2_9HELI/23-199   AC A0A3D8JBV2.1
#=GS A0A2N3PIA9_9HELI/11-185   AC A0A2N3PIA9.1
#=GS LNT_WOLSU/15-187          AC Q7MAR3.1
#=GS A0A1P8KJZ4_9BACT/11-181   AC A0A1P8KJZ4.1
#=GS E7G3B4_9HELI/11-191       AC E7G3B4.1
#=GS B9KCT3_CAMLR/25-199       AC B9KCT3.1
#=GS A0A3D8IN20_9HELI/266-439  AC A0A3D8IN20.1
#=GS A8ERU4_ALIB4/11-181       AC A8ERU4.1
#=GS A0A1B1U7G4_9HELI/9-194    AC A0A1B1U7G4.1
#=GS A0A3D8IW28_9HELI/19-195   AC A0A3D8IW28.1
#=GS A0A329ZN78_9HELI/17-188   AC A0A329ZN78.1
#=GS S3XY23_9BACT/11-193       AC S3XY23.1
#=GS LNT_HELHP/1-163           AC Q7VFP7.1
#=GS B6BKW6_SULGG/15-186       AC B6BKW6.1
#=GS A0A7M1AWH5_9BACT/8-182    AC A0A7M1AWH5.1
#=GS A6Q516_NITSB/15-198       AC A6Q516.1
#=GS A0A842J7K4_9BACT/24-196   AC A0A842J7K4.1
T1D0V7_9HELI/33-228                  iacsaifaflfclgvyvfalcsdlfafvpesmpdviipqsqtlsaq-----.--------------....--.-...............-..............N.YIGATLMSI...CAMLSIAVWF..IVP.KALRFWFGFFCGVFLFYWIGLSFRYSPLPFVGLFVPLCIGLVYGVLIFFA.........LYYESKL..........................YRLITLVLMSFIHPFGFDWFMPPALLSYSFFGVSWWHFVCLECAIAL..FLVR.S..SK..F...FMLLGLVLFVCSID-s......................
V8C9B4_9HELI/61-239                  .......................................fallnyy-----.-GLIFGILFSAWLY....AF.VgivevcggfsdnvsmW.............lN.MFGVIALSA...LGIVSIACYL..LAP.VRIRFYFGFFAGILLLYWIALSFRYTPFPFLIPLVWLGIGLIIGAIFWVL.........LFFKHII..........................FRIFTLMILGSIHPFGFDWLVPQSFFAYSAFGVSEWDFFFVVVGVAL..LVV-.-..--..-...---------------allrsdinf..............
A0A377JNE6_9HELI/19-197              .......................................kvfmwlf-----.ISFIFASFCVASFY....IQ.W...............Ife..........lcDvESPKILLSV...FGLLGIASVL..FTP.KNRRFSVGFFIGVLWFYWISLGLRYFDMSVLIPLVVVAEALLIACVFYVG.........LWCECLL..........................WRFGFIMLLSYFMPLGFDWIMLESVFAFSYFGVDKLSLGLIVLGLWV..AIK-.Y..ER..W...WKIIGILCLVLALD-s......................
A0A076FA87_9BACT/24-195              .............................................l-NFII.NGFAIATLLSFFIF....LS.I...............F..............EiVILNYIGCF...LAIFGLYLLL..NLD.KKTWFWTGFFVGILWFYWISFSLVYYGFWYLIPLEIIAIGLVYGLLFLIA.........GYFKSQI..........................LRAILLVALDYFYPFNFNWFNLELIFVGTIFKPSIWSLGAVLAGLIL..SK-K.F..KF..G...FVILAILMLL-----nlnl...................
A7GZ86_CAMC5/23-197                  ............................................st-KIII.KAFVGAFLLANFIF....LS.L...............L..............EnSLADFCSPF...LTLAGIYIII..NLP.RAGFFTAGFFTGILWFYWISFSFIYYELSFLIPFVIIFVGLIYGLIFWLA.........SFPSFVA..........................LRAVMLFLVSYIHPFGFNWLNLEATLVLGIFEPSVRGLIFVFLAAIA..LAC-.L..PK..I...YKFIAAFVCLVCA--lqf....................
I2K4Y1_9BACT/1-155                   ..............................................-----.--------------....--.-...............-..............-.-----MNTI...LGIITLYLLL..QEE.KKVWFFSGAFIGLFWFWWIALSLQHYGMVWAVPIEIVIIMLSYGVLFWFL.........AWISEKItallsvs............gtllpllLKALGLFILSYIHPFSFDWLKLELMFVESYLGIEKWQYAIILGAIVL..SIW-.-..KQ..H...FLYLFL--ILFA---yqsn...................
A0A3G9HEK7_9BACT/10-181              ...........................................tat---LS.LGFLSALCASAFIY....LF.H...............F..............G.LQFPYLQTL...LGLSALYFWL..TLE.RPALFWSGFFTALFWFWWIALSFRYYDLAWMIPLVMLGVSLVYGGIFWLI.........GSLGHTA..........................LRALALGLIEWLHPMGFDWFRPALLFTGSILGDSLWQLWAVLASLTL..LII-.L..RT..K...LRWIAAAGIVAAL--hi.....................
A0A2W6MU86_9HELI/30-204              .............................................y-EKLF.IPFICAIFFSAFIY....WE.H...............F.............fKsYNPPLLSTI...FALIALAFYF..HLK.KFGAFICGGFVGIFWFYWIGLSFRYYDLSYLIPFIVLFVALVYGIIFYFM.........CFFKNPL..........................YRTLMLVLVSFLHPFGFNWFIPELMLTTSYFEPSKTILFCLCLIIML..TQKM.F..AE..K...YYKMGGVFFLSSL--il.....................
A0A4Q0ZR49_9BACT/11-182              .............................................k-TNII.IGLITAISLSSFIY....LE.H...............Y..............E.IFSKLLNTF...LALISFYLLL..TIN.KKSFVIAGFFTGVLWFYWIGNSFQYYELEFLKYPVIIGIGLGYSLVFYFM.........TIVNKTW..........................FRILTIFLISFVHPMGFNWFMPELILVNSYFPFSKAHFALILASIYI..FIK-.A..HG..F...KKAIAIVPLIFIT--yn.....................
A0A6L5WJX3_9BACT/24-195              .............................................i-NEII.KCFFIAILISNFIF....LS.I...............F..............DnLWLNFISPF...LTIFGFLKLF..KFN.KIKFFYTGFFIGILWFYWVSFSLRFYDLSYLIPIEILFFGLIYGLIFLVC.........GWFKNLY..........................FRAFMLLSVSYFYPFNFNWLNLEATLVIGIFEPNLRGLGFIFAFIIA..YYS-.-..LN..K...FKFISIFLLIFALQF.......................
B5Z9V3_HELPG/5-184                   ..........................................lfnq-----.NAFLLACMFVSSVY....VN.A...............Vlda.......yaieNpYITITLTSL...LAPLSMLAFL..KTP.RNSAFALGFFVGALLFYWCALSFRYSDFTYLLPLIIVLIALVYGVLFYLL.........LYFENPY..........................FRLLSFLGSGFIHPFGFDWLVPDSFFSYSVFRVDKLSLGLVFLACIF..LSAK.P..FK..K...YRIIGVLLLLGALD-f......................
A0A3D8IAT8_9HELI/24-200              ............................................ks--YIL.IPFSLAFIFSIPLY....LN.I...............Ft...........yyKtIYFPYINGI...FALISIFIFI..NIN.RKYRFFFGFFVGILWFYWISLSFRFTSSPNILYIVIFFVSVIYGIFFYLL.........LFFKNKL..........................FRIFSISIASYISILGFDWFVPDSILAFSVFRVDKISFCLITLIIVI..ISLK.S..LK..I...YRFISLFALILLVD-f......................
A0A268U1V7_9HELI/90-257              ............................................vl-----.IIFFLLIPFYLRSY....FD.Y...............F..............P.-FFEWILSM...LYLVSLGVFL..LIP.RKYRISFGFFVGVLGLYWIALSFRFFGLEYFMPVVIIAIGIYVGVLFYFL.........LWFQNPI..........................IRIVALLILGLIHPLGFNWLDVNFFSAYTFFKPAIISMIVLSVAVIL..L-KN.K..DW..L...SSVISMVLILYSMQ-f......................
A0A6G5R329_9BACT/23-197              ............................................st--KIIrKAFFSAFLISNFIF....VS.I...............F..............DlAILNFISPF...LAIYGFYTLL..KFN.KYEFFTTGFFVGILWFYWISFSLAYYGFGYLIPLEILFIGIVYGFMFFIA.........AIPPQIW..........................LRAILLILISNLHPFNFNWLNFEAIFVVGIFKPNLYGFVFIFAAILS..LFY-.I..KT..K...LKFLAFITLLLFA--vqy....................
A0A329ZGP1_9HELI/50-224              ..........................................mlvd---CL.LGFLFCLPLYVLVF....FDvC...............F..............EsDTPLWLGSV...AGIISVYVYM..RMP.KNRRFGVGVFVGLFCFYWVGLSFRFVGLEYLVPVISLLVALVYGVVFWLV.........AFCECLL..........................VRLLGLLLLGSITPFGFDWLNVSSFFAYSYFGLELLHLALIVCAVYL..FIT-.-..RT..T...LRLLGALVLLFLA--ldf....................
A0A1S6UAM6_9BACT/23-195              ............................................tt-KIII.KAFVSAFLISNFIF....LA.I...............F..............DyEILNFISPF...LTILGIHLLI..NTD.RIGFFLTGFFVGILWFYWIGFSFIYYEMTYMIPIVIISVGIVYGFIFLIA.........SFPSFVF..........................LRAVMIFLISYIHPFGFNWFNLEATLVLGVFEPSTKGLICIFLSAYF..L--R.F..NK..F...YKLLFLIPLIFAVQ-i......................
A0A4Q0XPT8_9BACT/11-178              .............................................k-TNII.KGLYTSFFFSAFIY....LS.L...............F..............E.IEFKLLHTL...LALLAIYHFL..RVP.RQALFMAGFFVGILWFYWVGFSFTYYELAYLIPLVILGFALFYGFLFFAC.........TIIDNII..........................FRSLALIGLSFLEPFGFNWFNPELLFVHSYFDIDKLSFMLIVLSMAM..VTQ-.-..--..-...FRLIALIPLVFAVQ-f......................
A0A6M0L085_9BACT/10-191              ............................................ti-KIIT.TGFVIAILSSGAMY....LD.W...............L..............G.FVNHFVNTI...LGILMLYWLL..QSD.KKVWFWGGFWIGGLWFWWMSVSFFNYGFAWAIPLGVLFPSLVYGFVFWII.........AKIAEIIgqkiegqt.........hgsaptvlvIKALALLALSYLHPLGFDWFKPELIFTNSYLGIEKWQFAIVLFAISM..TIYK.-..--..-...---------------qgqprgarlk.............
V8CKL6_9HELI/55-241                  ...........................................var---LM.LGLLYALGFCAWLY....VF.V...............Lvagfft.ldssllaQ.ALSALLMSA...LVLVSFSIWL..LVP.RAIIGYFGFFAGLLLFYWIGLSFRFSVAPYLLGFVCVGIGLIYAALFYLG.........LYFTSKL..........................YRIASLFVLGVFAPFSFDWFVPKAWLAYSVFGVGDLAFVGIMCALAL.gLYRG.G..AR..K...IRILGSVAILLVC--id.....................
E0UPN9_SULAO/4-177                   ...........................................ftk--IFL.LGIVTAALFSAFIY....FE.Y...............F..............G.ISNKLINTF...FGLGAIALLL..YIP.KKAVLVAGFFIGLFWFYWIGYSFKYQGVGYMEPIITFSFGIIYLIFFAPL.........SFTDKPY..........................IRAVLLFGLSFIEPLGWNWMKIELLFVNSYIGVYKYQLVAVLLALSL..PALI.K..HK..T...YKFLPLLLLVFAFN-y......................
A0A7L8V522_9BACT/22-194              .............................................k-TNII.KGFFGALFFSLFIY....LD.F...............F..............G.LENRAFNTL...FALIGLFMLI..YLD.KKSIFWYGFFIGLFWFWWISISFIYYELSFMIPLVVLFFALLYGVLFYVS.........TIFDRWN..........................IRFLALFLLSFFEPLGFNWFKMELIFINTYFSADKFTLFASLFLAYV..AINI.P..KK..R...YAFLLLLPLVFFID-l......................
A0A3D8HSU7_9HELI/84-261              ......................................cfiilvdc---IL.AFAFCAPLYGLHLF....ES.V...............F..............GrEIPLFLGSI...LGVLSIYVYL..RMP.KSRRFGVGFFVGIFCFYWVGLSFRFIGLSALVPIVSIAVALIYGVIFWFI.........AFCECLV..........................VRLLGLLLLGFIAPFGFDWLNVQSFLAYSYFDVDFLHFTLLVCALYC..FIA-.F..TR..A...RLIIGALCLIFALD-f......................
A0A1X9SRF2_9BACT/23-194              .............................................l-KFII.KGFMISILLSLFIF....LD.L...............L..............NlKYIANLGLL...SAIIGLYILL..KSD.RKIWFWSGFFIGLFWFYWISFSLVYYNFGYLIPIEILGICLIYGFIFLAV.........SWLESIY..........................IKAIFLLFASYVAPFGFDWLNFELIFVDTLFKPTIYTLALVLISIII..AIK-.-..FN..I...YFGISLLICSLAIN-y......................
A0A091B238_9BACT/9-180               .........................................idlfy-----.LPLAIAFGFSAFIY....IE.H...............F..............G.LTSKLVNTA...AALGALYGML..YAP.RRTLPIAGFLIGLLWCYWIGFSFQYYGLGWATELVALGFGIVYLLFFGIL.........GLTSNPL..........................IRAVLLFALTFVWPMDFNWMQPELIFVESYIGIQKWQFALVLFALAA..AYW-.L..RG..W...KKGLSFLILIAA---yep....................
A0A1I5N2Z2_9BACT/15-186              ............................................tp--TIS.LGFFSSLFSSAFIY....MH.H...............F..............N.IHLPLLQAL...LGIVALWFWL..KLS.PKEMFWSGFFTAIFWFYWIALSFRYYDLNWMIPFVIVGIGIIFGILFRLI.........AAFPHIL..........................LRAVAIGLIEYLHPLGFDWFRPALMFTNSALGDHIWQLWIIISSLTI..FIM-.I..KQ..K...TRYLALLLILLSIQY.......................
A0A347VT85_9HELI/130-297             .............................................i-KDCK.KYIFYFLLVILFII....IF.S...............F..............LhKNHYFLSSV...GYVISIAIFL..FLK.RKFRFLFGFFVGVFGFFWIPLSFRFDDLSAFIPLAIIGIGLIYGIIFYFL.........MYFNNLF..........................FRFLSCLCLFFIAPFSFNWLNLAYFSAYSIFSVGSLALLMIFLIF--..----.L..KK..R...YYFLSFIFFLVSLD-y......................
A0A268TA81_9HELI/5-180               .....................................ylvsafilg-----.AIFLIPVYGSILFF....YQ.D...............W..............Q.KEILVFNSI...FALLSVWVWF..SVP.KKIGFWFGFFVGLGLFYWIGLSFRFSVMEFLIPIIMVGVGVGYGIIFYFL.........LWFPSWL..........................YRMITLMIMSYIHPFGFDWMVVESFFSYSIFGVDKLHFLCIIVGVGV..WIH-.F..KR..F...YRIFAVCFLLFGID-w......................
A0A2N1J6J8_9BACT/11-181              ............................................kt--III.KGLLTAILLSCFIY....LS.H...............F..............K.IEIKLLNSI...LGLASIYMLL..TIP.RLSLVIAGFFTGILWFYWIAFSFVYYELSYLIPFITISFGLVMALLFFLI.........DFIKKPI..........................FRAFAIFALTYIEPFSFNWFKLELLFIDSYFNTSKLAFALIIISMFF..LTR-.-..KL..K...YKPLAIVFLLFAIDY.......................
A0A381DGQ8_9BACT/1-103               .............................................m-----.--------------....--.-...............-..............-.---------...----------..---.-----------------------IYYDFGFFIPLEIFGISIVYALIFLFI.........GSFSNLF..........................IRAILLLIIKFIHPLGFDWLNFEVMLVEGIFDPSIRGLGVILLSIII..FIK-.-..FK..K...LKFIAPFLLIFGLQ-f......................
A0A099TY74_9HELI/132-301             .........................................itipk---IT.NTVCIAI---CITF....LH.I...............M..............H.KNPYIAVSL...SYLVSIAILL..FPN.RKYRFYIGFFIGAFGFYWMALSLRFEQASEFIPALIVCIGLIYAIIFSII.........FFFQNVW..........................IRIIAILSLSIIHPFGFNWLNLAYFSAYSIFTPSLASLACLCVCLVF..ITM-.-..KN..R...LSVLSILLAIISYD-y......................
E6X2X4_NITSE/1-197                   ............................................mg-----.-ALLTALSGSAFLY....LA.W...............L..............G.WEPRWLDTL...LALIFYWRLL..GSD.RRHWFWTGFFLGLLWFWWLGVSFIHYGHPGALPFVDLTVALIYALIFWIF.........AFTAETMttwakyflkkfs..ilnsqfsirsswLKAAALLTMSYAHPFGFDWFKAELPLVPGYFGVDKISFASLLFGLCL..AREA.-..--..-...---------------weayhqkrhryavvlgllgtlfl
A0A292YCG5_9BACT/15-201              .........................................ryfnt-----.NSLIVATFVSLPIY....LN.F...............Fllkf......gstdN.FLTEFIFTF...LLLLALFVFF..Y-K.KHSFFQTGFFIGIFWFYWIGLSFRFYNLTFLIPFVILIIGLFYGSVFWLIkkiesfiknVYLKKIY..........................YILIFTFAFDYLTPFTFDWLKPEILFVNSFYGVDKITLFIVFFSILF..Y--E.I..DK..K...FLLLLFIPLFFI---skp....................
T0KSN9_9BACT/15-186                  ............................................vf--NLL.VGLLTALLFSAFIY....FE.H...............W..............G.FSFKLINTL...FGLASIALFL..YIP.KRAVLAAGFFIGLLWFYWIGYSFEYTGVGYLTPFVSFGFAIIYMLFFGAL.........ALSKEVC..........................IRALLLFGLSFFEPFDWNWMQIELVFVESFIGIHKYQLIIVLLALSL..PHY-.I..KK..P...YKYAPLALLILAIN-f......................
A0A5P8P229_9BACT/11-181              .............................................f-FHII.RGFISAIFFSAFIY....LE.H...............Y..............G.YTFKFLNTF...LGLLAIASML..YLP.KKSILSAGFFIGIFWFYWIGYSFEYNEVGYLTPFITFSFGVIYFLFFGTL.........ALSNKPY..........................IRAIILFGLSFFEPFDWNWMQIELLFVNSYLGIYKYQLILILTSLTV..PFY-.I..KN..K...FKYSPLLLLILA---np.....................
A0A7U4M2L7_9BACT/13-207              ...........................................tfv---LT.RGLSIALLGSAFIY....LE.H...............W..............G.FSVLWLNTI...LGISFLYLLL..SSD.RSIWLITGFFLGIFWFWWIALSFKHYHMPWAIPIVVIVMGLLYGTLFWAI.........AFLAEKIptinksvaiqlkptlftlhsslftlsLKALGLLGLSYIHPFGFDWFKPELIFVESYFGIQKWQFAIILAGIVL..TLW-.-..KK..Q...YAYLFLVLF------awqp...................
A0A975GCB6_9BACT/5-177               .............................................i-KTIS.FGILTALLFSSFIY....FE.E...............Y..............D.LTNKLVNTI...TALLALGLFL..YIP.KRSVLVAGFFIGLFWFYWIGYSFEYQGVGYLTPVITLSFGIIYLLFFMPL.........YFTDKPY..........................IRAFILFGLSFVEPFDWNWLQVELLFVESYLGVYKYQLALILAALSI..PVLI.Q..NK..K...YRFLPLLIIIFAFN-y......................
A0A128EDR8_9BACT/1-161               ..............................................-----.-------MISNFIF....LT.L...............F..............DnLILEFISPF...LAIYGFYKLF..DAN.RFEFFHTGFFIGILWFYWVSFSLVYYGFAFLIPLEILFFGLVYGLIFLVC.........GWWKNKF..........................IRAILLILISYFYPFNFNWLNLELVLVPGLFEPNLRGLCAIFAGILA..FYY-.-..LK..K...FKLLGLFVGVI----lalqi..................
A0A1B8JA47_9HELI/83-265              ........................................arltfg-----.--ALLAVIFSLWVY....GF.I...............Flsrffd.idasgvsQ.VLALIAMSV...LAFLAIVVWF..VVP.RKVGAYFGFFMGIFLFYWIGLSFRYTDFVFLMPIVAFSIGIGYAVLFYLA.........LFFDSRI..........................YRIFSLLILGAMKPFGFDWFVPQAWFSYSFFGVGAWDFIFILCAAAL..VAP-.-..--..-...---------------rieafgrnkcrvifassa.....
A0A4Q0XYU3_9BACT/11-182              .............................................k-TYII.KGLITSLFFSAFIY....LA.H...............F..............N.IEYKILDTI...LGLVSLYLVL..KID.KKALFVAGYFIGIFWFFWVGNSFEYYNLGYLSFFIPLFFGLGYGIIFFII.........GVFDFTF..........................YRAFILFVLSFIHPFGFNWFIPELLFINSFLDTSKISFALILLSLFI..LIE-.F..PK..K...TKILAVISLLFTY--tn.....................
A0A222MXM3_9BACT/24-197              .............................................s-FKII.KAFFIAFLILNSIF....IS.F...............Y..............PnLALQILSPF...LSIWGFVLLL..RSD.GKGYFYTGFFLGILLFYWISFSSIYFNLAWIIPFEILGIGLFYAILFRLI.........YMLKFDF..........................LRLSAVFALSFLHPLGFDWLNWGILTVYGSFDASYKGIICIFLIAYF..YYEK.Y..IS..R...YYKIAIILFLFFL--gt.....................
A0A2A2GV91_9HELI/49-226              ...........................................lfy---LL.SNAFLAFMFALPIYgiwaFE.S...............Y..............HlDMPYFLGSI...LGALSFYIYL..RIP.KTRRFGFGFFVGIWWFWWVGLSFRFIDLSFLVPIIALAIALVYGVIFWIL.........LFCECLP..........................VRLIGLLIMPFITPFGFDWLVPQALLSYSYFGVDSLHICFLILALYA..LILA.H..TK..K...ILPILALSSMLAI--aa.....................
LNT_HELPY/5-184                      ..........................................lfnq-----.NAFLLACMFVSSVY....VN.A...............Vlda.......yaieNpYISITLTSL...LAPLSMLAFL..KTP.RNSAFALGFFVGALLFYWCALSFRYSDFTYLLPLIIVLIALVYGVLFYLL.........LYFENPY..........................FRLLSFLGSSFIHPFGFDWLVPDSFFSYSVFRVDKLSLGLVFLACIF..LSTK.P..LK..K...YRIIGVLLLLGALD-f......................
A7I0M5_CAMHC/1-156                   ............................................mi-----.-------------F....-A.F...............F..............QnFWLEFLSPF...IAIYGLLRLL..NSN.REIFFWTGFFIGILWFYWVSFSLIYFGFAYAIPLEILFFGFAYGIFFRIC.........GHFKNLI..........................LRSVLLIGLAFFHPFSFNWLNLELILMPGIFEPDLRGISAVFAGICA..FYY-.-..FK..K...FKILWIFVCLIF---alqi...................
A0A7S7M2N0_9BACT/1-172               .............................................m-FDLI.SGVVTALFFSAFIY....FE.H...............L..............D.ITLKLLNTI...FALLSLALFL..YIS.KRAILVAGFFIGILWFYWIGYSFEYNGVGYLTPFITLIFAIIYMLFFGVL.........ALTNKVY..........................IRAALLFGLSFFEPMDWNWLQIELIFVDSYIGVLKYQLAVVLVAISL..PNY-.L..KM..P...YKHVPLLLIILAF--sf.....................
A0A363D426_9BACT/11-181              .............................................k-NFII.KGFISSILLSSFIY....LS.Y...............F..............N.IEIKFLNTI...VALFALYFLL..IIP.KKALFISGFMTGILWCWWMAVSLQYYDLVYLTPVILICIGIVFGLIFYFF.........ALFDRLT..........................FRILTIFAFTFFAPFGFNWMKFELIFIDSYIGIDKLSFILVLISFYF..IIK-.-..LK..R...FKILGIIPLLFALS-f......................
C5ZXZ2_9HELI/12-185                  .............................................l-TQIT.LGILAALFLSAFIY....EE.H...............Ff............yT.WKHPFFSSF...FAILGFFMLL..HFS.RLSAFICGSSIGILWFYWIGLSFRFYNLTYLIPLVWIFVALIFGIFFLAL.........CYFKNPI..........................YRISALLCASFIHPFGFNWFIPELTLTQSYFFSSKSILALLLISLII..FGFL.I..QK..R...FYKIGFFGLIL----glf....................
A0A3D8I019_9HELI/33-210              .........................................iknwl----F.IPFILAFIFSLPLY....AN.F...............Yty..........lnE.EYFPYINAI...LVLISLFTYL..NIN.KRFAFSFGFFIGLFWFYWIGLSFRYTNSAYLVYVIPIIVGIIYAILIWLA.........LFFNNII..........................FRAITLSLIGYVTIFGFDWFIPDAMLSFSIFKVDKISFIIIVATLSI..ISIK.Q..IK..L...LRFLAIFLLFFAIDF.......................
A0A7M1LG25_9BACT/24-195              .............................................t-NEII.KGFCLALFLSNFIF....VS.Y...............F..............EnLVFEFISPF...LVIFALFILI..RSN.RFEFFHTGFFIGIFWFYWVSFSLRFAQASYLIPFEILIFGVIYGLIFLAI.........GWFKSVY..........................IRAILLLGVSYFYPLNFNWLNLELTLIYGIFEPNLRGLGAILLSIIV..FIK-.-..IA..K...FRVLLSLLVLFL---glq....................
A0A7H9CIJ2_9BACT/22-189              ............................................le--FIK.IGFINALLMSAFIF....FA.L...............Fea..........dfG.RFYDFVASFacaLFIIGFVCMItrNPN.ASTWFWGGFFIGIFWFYWIAYSLIYFELAWLIPFEIIAIACLYGIIFAFC.........FLIFKIFyiisikilk.......lkfqkllkiiFLSVALFCAQFIHPFGFNWLNFSLPFLNTPLQ---------------..----.-..--..-...---------------silig..................
F8KR23_HELBC/12-191                  .........................................gygfv-----.--CVCVLLFLLPVY....GS.L...............Ll...........ahHpMPLVIFGSF...SAPLSVWAYL..SVP.AKRRFFFGFWVGLGLFYWCALSFRYNDNVFLLPLIMVLIALCYAVVFYGL.........LYFNSLL..........................YRIATLWLSSYIHPFGFDWFVPDAFFAYSGFKVDRLSFLGVIVAIAL..FMQR.Y..KN..-...FMFFKPL--------yapskifavvllvl.........
A0A4U8UEX7_9HELI/11-183              ............................................lh--QSL.IGILCAISLSAFIY....LE.H...............F..............S.LNSPIISTL...FAIVGLFLYL..QLS.AFGGLVCGGLIGILWFYWIALSFRYYDIAYLMPLMWIVLILVYGILFLFF.........CAFNHYV..........................YKLLTLLCGSFIHPFGFNWFIPEAIFTTSYFTPSKWTLVLLLLSLMI..FSML.Y..LK..R...FYKISLLWLPMSL--ic.....................
A0A2P8R1Y2_9BACT/25-196              .............................................i-NDII.NGFFIALLLSNTIF....LT.L...............F..............DnIFLNFISPF...LAIYGFYKLF..EFN.KIKFFYTGFFVGILWFYWVSFSLIYYNLSFLIPLEILIFGIVYGLIFLIC.........GAFKNKL..........................IRAILLLSISYFYPFNFNWLNLELTLLSGIFEPSLRGLGSVFCFILF..FYY-.-..LK..K...YKYLASIFLLFALQ-i......................
J1FBX3_9BACT/2-177                   .............................................i-KEIL.KSFGVASLLSAFIY....LH.H...............F..............G.FENQFIETI...LGISGIGFLL.fEYE.RKVFFWTGFFTGILWFFWMPFSMQYYGFPYLIPPSIILLGIAYGIFFFIV.........GYFDRIS..........................TKASLFILLTFFEPFGFNWFKPQIIFVNTPFGTETWQFAIIVFSIAL..SIFA.FleRK..K...FLYFAPLLLLFAID-f......................
A0A6G5QI48_9BACT/24-195              ..............................................IKKII.KAFVYALMLSNFIF....IS.I...............F..............EnKILDFISPF...ITFFAIYNII..NLD.RCGFFWAGFFSGILWFYWISFSFIYYELAWLIPLVIFGIGVIYGLIFLAA.........SLPSFVA..........................LRAILLFIFSYIPPFGFNWFNLEATLILGIFQPNIRGLIAIFLAAIL..ASY-.L..KG..Y...LRIIAVIVSL-----afgv...................
D5V282_ARCNC/11-182                  ............................................ki--NII.KGLITALLFSTPIY....LA.Y...............F..............G.FEIKIINTI...CLLLSLYFIL..KID.RISLFYSGFFVGILWFYWVSFSFRYYDLSYLIPLVILFFALVYALLFLLI.........SIKDNIY..........................LRAILFFALAFFNPFGFNWFKPDILLLDSYFEANKIVLGLIILSTIF..LVK-.K..RV..L...IYTICIIAISFI---hin....................
C8PJY0_9BACT/23-207                  ............................................ls--YIN.KGFVLALALSNFIF....VE.I...............Lssk.......fdglGaLAAEFFSPL...IAIAALFYLL..KAS.KAEWFWCGFFIGALWMHWISFSLIYFDLAFLIPIEILGICLVYAFIFRIF.........VIFDAPV..........................LRAACLLILKFIHPFGFDWLNFELLLSHGIFRADLSALALILAGLCTvlYLRG.R..GA..R...AKLNATIFAVFLI--calq...................
LNT_CAMJE/24-198                     .............................................i-FKII.KVFFIAILLSNSIY....LS.F...............F..............EnIFTQTISPF...LAIWGLVLLL..KSKtSKQYFWIGFFVGILWFWWIGLSSIYFNLNYLVPIIPIIIGFIYGLLFRLC.........YLLKFDF..........................LRLCGIFCISFIHPLGFDWFNWGIFTVYGFFDPSYRGIICIFLIAYF..IYEG.Y..IS..R...YYKIAIVLILFFS--gf.....................
D3UIP7_HELM1/13-198                  ............................................le--KSK.KSFFFVFLFLLPIW....SG.A...............FffalgdsgghargfE.TTYIILNSI...FAPLAIFAFL..RVP.SSLGFYFGFYVGIGLFYWVGFSFLYSPAPYLLPIIIIAMGVIYGVVFWPL.........LWSEHLF..........................FRIPALFLLSFIHPFGFDWLFGEEFLAYSIFGVGKWSYACVILGVVL..LYK-.G..GK..G...FKILAVFLLGFSIS-q......................
C3XE46_9HELI/161-331                 .......................................vvdtalp-----.-FFLVFIILCVGIF....-S.L...............L..............H.KNTYIGVSL...CYPLSIAIFL..FMP.RMYRFWFGFFVGIFGFYWMTLSFRFEGLSLLIPFIVICVGIIYGLFFWIL.........LYFQNLV..........................WRIIAMASLFILHPLDFNWLNIAYLSSYSVFEASLLSLLCVAFACYF..IIT-.-..KS..A...LQLLAPLLLLMSLD-y......................
Q30Q77_SULDN/16-187                  ............................................lf--DLY.LGVITALLFSAFLY....LE.H...............F..............E.ITLKFLNTI...FGLCAIALLL..YIP.KRAVLVAGFFIGLLWFYWIGYSFKYNGVGYLTPLITFAFAIIYMLFFGIL.........ALTKSVA..........................IRAILLFSLTFFEPMGFNWLQLEVLFVDSYIGIYKYQFATILISFTL..VEY-.I..KK..P...YKYAPLLLLFFAIN-f......................
A0A4U7BQC5_9BACT/24-197              ............................................il--KII.KSFFIAILLSNSIY....LS.F...............F..............EsLALEIFSPF...LAIYGLVLLL..RSD.KIGYFWAGFFLGILWFFWLSFSSIYFGLSYLIPFEILGIGLFYGILFRIC.........FILKFDF..........................LRLCGVFLISFIHPLGFDWLNWGVLSVYGFFESSTKGVICMFLIAYF..YYER.Y..IS..R...YYKIAIILALFFI--gm.....................
A0A3D8JBV2_9HELI/23-199              ............................................lq--KQL.QTFLFALIFSLPIL....SG.T...............Lfls........lgyE.RLYIALNTL...FALCALIAFI..KID.KKMRFYFGFYVGVLLFYWIALSFRFSPMPILIPLIIFLVASIYGLIFTFL.........LWFENIF..........................FRILALLFLGYIHPFYFDWLFVESFFAYSIFGVDKISFCCVLLGVFF..LLQ-.-..KG..K...IRIFALLFLTLAT--lq.....................
A0A2N3PIA9_9HELI/11-185              ...........................................lhg---IL.AGILCALFLSAFIY....LE.H...............Fl............dN.KNFPLYSTL...FAILGLFLYF..KLS.RLGAFVCGGILGILWFYWVGFSFRFYDLSHLIPLVWIVFFVVYGALFYLF.........CFFSSPF..........................YRLVALTLSSFIHPFGFNWFIPEVILTKSYFFPSKFTLFLLLCSILI..LSAF.L..AK..K...LYKTSLIWLCSF---all....................
LNT_WOLSU/15-187                     .........................................pkslg-----.IALFGAILFSLFIY....LH.H...............F..............G.ITSPLLYSL...LALLALAFYL..KLP.RESGFAFGFWVGIAWFYWMALSFRYYELTYLIPFILLGIGGVYGVLFSMA.........LYLKNPL..........................VRALLLWLLSHVQPFGFDWMVPEVMLVPSLLDSSKLSFGLILLSLSL..FWLL.P..QR..W...LKPLPLLLLPFTL--ys.....................
A0A1P8KJZ4_9BACT/11-181              .............................................k-KFII.KGLITGILLSAFIY....LS.Y...............F..............N.IEYRFINTV...LGLLGLYFLL..TIP.RPSVFFAGFTTGVLWCYWMTVSLEYYDLVYLTPILLILIGLVYGLIFLIF.........AIFDKTS..........................IRLILIFTFTFIAPFGFNWMKFELIFIDSYLGTSKEDFALILLSLFL..MIK-.-..LH..R...MKILSILPLLFAIN-i......................
E7G3B4_9HELI/11-191                  .............................................s-KELI.QPLVLALLFLSPPY....LG.C...............Li...........apHlKILLGLETF...LAPLSMLACL..LVK.AKQRVFFGFCVGLGLFYWCALSFRYNDYPFFMPLIIILVALCYAGVFYLV.........LYQQFLF..........................YRVVTLWLTSYIHPFGFDWLVPDAFFAYSLFKVDKLHFLMILIALAL..YVYKnP..LV..KpfyMKSLASLILLFC---ley....................
B9KCT3_CAMLR/25-199                  .............................................t-FKII.KAFFSALLLSNFIY....FS.F...............F..............EnLLFEFISPF...LSIYGLILLL..RNKsKTGYFYTGFFVGILWFWWIALSSIYFDLAYLIPLEIILIGLVYGLLFLVC.........FFLKYDF..........................LRLCGIFLLSFVHPFGFDWLNWGVLSVYGIFDASYQGIIAMFLIAYF..YYEK.Y..IS..R...YYKIGIILILILI--ga.....................
A0A3D8IN20_9HELI/266-439             ...................................rffsqeyyivy-----.------NWILLFIY....IF.V...............Fs...........vlH.NNDYVLVSI...FYPISAIIFV..FFP.RQYRFSFGFFSGLFGFYWMTLSLRFNGLSEFIPLSMLCVGLVYAIFFWFL.........LYFENVF..........................YRILACLSLFVLHPTGFNWLNIAYLSSYSIFNSSFFGLVCVLVFLWC..VAL-.-..SS..K...VRFLAPLFLLLAFD-y......................
A8ERU4_ALIB4/11-181                  ............................................qn--FII.KGLLTAILLSLFIY....LS.Y...............F..............D.IEIKIINTL...IGLLGIYFLL..TIP.KKALFIAGFFTGILWCNWMSVSLQYYDLKYLTPVLILGIGLVYGIIFYLF.........AFIDKLT..........................IRILMVFGFTFFAPFGFNWMKFELLFIDSYISTSKIAFALILISFYF..IIK-.-..LK..K...HKLLGIIPLLFIFD-f......................
A0A1B1U7G4_9HELI/9-194               ..........................................ltrr----I.GEVYLAFVFVLPLY....LV.W...............LfefhlppllgtfqtQ.NILYFLNTC...FGLISFYVFL..TLP.SRSAWGFGFWVGLLSFYWVGYSFVYFGFSYLVIPIALFVASVYMVILRCA.........LWFEHII..........................LRSVALLSLSYIHPFEFDWFVPDSLFAYSFVGVHKWQLVLVVCGLMI..WK-S.N..RD..F...WRFVAIVPLCLALE-l......................
A0A3D8IW28_9HELI/19-195              ............................................ee--KVL.KTFFYSLIFVGPIY....CV.H...............Ffe..........ifDrDPYSWLITL...LALGSVAIFF..LIP.SSKKFWFGFFVGLLWFYWVGFSFFYFGAPILVPVIAVVVAGIYMLLFVVA.........LYYPSYI..........................WRGVWLVLLGYIHPFGFDWLLVDSFFAYSYFGVQKYDFILIVLGIAF..ILQ-.T..QD..R...KQIVGIAFLICALD-y......................
A0A329ZN78_9HELI/17-188              .............................................i-RKIA.KGLVAAICLSLFIY....LY.H...............F..............G.VRNIWVYTI...LGIFSLFYYL..KSD.RSYRFFFGFFVGILWFYWVPFSFRFFGVDYLIPLAVVGIGIFYGLLFYIV.........LYFQNVW..........................YRAILLFFLPYFAPFGFDWLNLRAAFVLTPLNISNIGYALIILSIVL..MVH-.L..KG..S...YRLLSVLVLIFSL--ll.....................
S3XY23_9BACT/11-193                  .............................................t-NEII.KGFVISVFISNFIF....LG.Flsen.......fggiF..............NnLFLEFISPF...IAIYGFYKLF..NCN.KIAFFFTGFFIGILWFYWVSFSLKFYGLSFLIPLEILFIAFVYGILFLIC.........GWFNNKF..........................YKMVMLLLISYFYPFNFNWLNLELVLMPGIFEPNIRGLAFIFLGIIA..LYE-.I..KN..K...FKKAFIFIVCLCL--slqi...................
LNT_HELHP/1-163                      ...........................................mlp-----.--------FYAQWV....LE.S...............Y..............DkAISPLLVSL...LGLFSIASVL..FVP.KNRRFGVGFFIGMLWFYWISLGLRYFDMSFLIPLVVIACGIFMGFVFYIG.........LWCECLI..........................VRFAFLLLLSYLTPFGFDWIVPESVFAYSYIGVDKLSFALSILALWI..LFK-.Y..KT..W...WKLGGVICLVFALDF.......................
B6BKW6_SULGG/15-186                  ............................................lf--DLL.IGLVTALLFSAFIY....LE.H...............W..............G.ITLKLFNTI...FGVAALGLLL..YIP.KRAILVAGFFIGLLWFYWIGYSFKYNGVGYLTPFITLSFAIIYMLFFGVL.........ALSNKVY..........................VRALLLFSLSFFEPFDWNWLQIELLFVDSYIGLFKYQLFFVLAALTL..PNY-.L..KF..K...YKDASILLLLLALN-f......................
A0A7M1AWH5_9BACT/8-182               .............................................t-KDIL.FGLVSALFFSTFIY....LS.D...............F..............G.LENKLLNTF...LGLVAIGSVL..YIP.KRSVLVAGFTIGILWFYWIGYSFEYQGVGFMTPIVTLGFGVLYLLLFLPM.........YFTTNPF..........................IRAALLFGLSFLEPFDWNWFKPELLFIDSFIGVYKYQFGFVLLALAS..TLYA.Y..KHypK...YKYYPLVLLVFAIN-f......................
A6Q516_NITSB/15-198                  ............................................it--LLI.KSFLIALLFSLFLF....LD.Y...............F..............E.MHSTFLTSF...FALTAFYLLL..K--.QRKIFWSGFFIGIFWFWWIGLSFRYYELHWMIPIIIFFVGFVYGVIFLSG.........YFLTDCFasffpky............sthlqtlFRASFLLTLSYIRPFGFNWFIPEIALVPTYFAFDKLSFAMFLVILVL..FIR-.L..KK..W...YRFLPPLGLLLIVQ-p......................
A0A842J7K4_9BACT/24-196              .............................................t-KIII.KAFVGAILISNFIL....AD.V...............L..............GgEILNFISPF...FAIAGFYLLL..KFD.RRGFFWTGFFVGISWFYWISFSLVYYELGYLIPLEILAIGIIYGALFLIA.........GIPAQIW..........................LRALLLILVTNIHPFGFNWLNLEAVFVPGIFAPSLLALTFIFAAILC..LFY-.V..KN..R...FKFIAFVALLACA--vq.....................
#=GC seq_cons                        .............................................h...lh.huhhhAlhhSsaIY....lp.h...............a..............p.hhhthlsoh...lulhulhhhL..phs.+pthFhsGFFlGlhWFYWluhSFcYaslsaLlPllllslullYGllFhlh.........hahpphh..........................hRhlhLhhloalcPFGFsWhphEhhhs.ShFsssphshshllhulhh..hhh.....tp..p...a+hlullhllhsh..h......................
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