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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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 02020 Two-component system
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04010 MAPK signaling pathway [PATH:rno04010]
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04013 MAPK signaling pathway - fly
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04016 MAPK signaling pathway - plant
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04011 MAPK signaling pathway - yeast
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04012 ErbB signaling pathway [PATH:rno04012]
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04014 Ras signaling pathway [PATH:rno04014]
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04015 Rap1 signaling pathway [PATH:rno04015]
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04310 Wnt signaling pathway [PATH:rno04310]
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04330 Notch signaling pathway [PATH:rno04330]
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04340 Hedgehog signaling pathway [PATH:rno04340]
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04341 Hedgehog signaling pathway - fly
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04350 TGF-beta signaling pathway [PATH:rno04350]
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04390 Hippo signaling pathway [PATH:rno04390]
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04391 Hippo signaling pathway - fly
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04392 Hippo signaling pathway - multiple species [PATH:rno04392]
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04370 VEGF signaling pathway [PATH:rno04370]
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04371 Apelin signaling pathway [PATH:rno04371]
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04630 JAK-STAT signaling pathway [PATH:rno04630]
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04064 NF-kappa B signaling pathway [PATH:rno04064]
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04668 TNF signaling pathway [PATH:rno04668]
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04066 HIF-1 signaling pathway [PATH:rno04066]
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04068 FoxO signaling pathway [PATH:rno04068]
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04020 Calcium signaling pathway [PATH:rno04020]
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04070 Phosphatidylinositol signaling system [PATH:rno04070]
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04072 Phospholipase D signaling pathway [PATH:rno04072]
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04071 Sphingolipid signaling pathway [PATH:rno04071]
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366697 Sptlc2; serine palmitoyltransferase 2
361213 Sptlc1; serine palmitoyltransferase 1
296188 Sptlc3; serine palmitoyltransferase 3
500651 Sptssa; serine palmitoyltransferase small subunit A
100362555 Sptssb; serine palmitoyltransferase small subunit B
290658 Cers1; ceramide synthase 1
310667 Cers2; ceramide synthase 2
304208 Cers4; ceramide synthase 4
499174 Cers3; ceramide synthase 3
366065 Cers6; ceramide synthase 6 isoform 1
366984 Cers5; ceramide synthase 5
58970 Degs1; sphingolipid delta(4)-desaturase DES1
314438 Degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
289322 Degs1l2; sphingolipid delta(4)-desaturase DES1
498300 Degs1l1; sphingolipid delta(4)-desaturase DES1 isoform X2
308909 Smpd1; sphingomyelin phosphodiesterase
353229 Sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1
310849 Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2
24835 Tnf; tumor necrosis factor
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor
353233 Nsmaf; protein FAN
83537 Smpd2; sphingomyelin phosphodiesterase 2
84431 Asah1; acid ceramidase precursor
114104 Asah2; neutral ceramidase
313339 Acer2; alkaline ceramidase 2
301118 Acer1; alkaline ceramidase 1
246756 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein
311786 Traf2; TNF receptor-associated factor 2
171293 Ctsd; cathepsin D precursor
64625 Bid; BH3-interacting domain death agonist
24887 Bax; apoptosis regulator BAX
367149 Bax-ps1; apoptosis regulator BAX-like
681314 apoptosis regulator BAX-like
365057 Map3k5; mitogen-activated protein kinase kinase kinase 5
25272 Mapk10; mitogen-activated protein kinase 10 isoform 2
50658 Mapk9; mitogen-activated protein kinase 9 isoform 2
116554 Mapk8; mitogen-activated protein kinase 8
81649 Mapk14; mitogen-activated protein kinase 14
60352 Mapk12; mitogen-activated protein kinase 12
29513 Mapk13; mitogen-activated protein kinase 13
689314 Mapk11; mitogen-activated protein kinase 11
25522 Prkcz; protein kinase C zeta type
24185 Akt1; RAC-alpha serine/threonine-protein kinase
25233 Akt2; RAC-beta serine/threonine-protein kinase
29414 Akt3; RAC-gamma serine/threonine-protein kinase
24224 Bcl2; apoptosis regulator Bcl-2
24672 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
24673 Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
100362453 Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like
117281 Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
315648 Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
246255 Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
60660 Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1
117256 Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1
117104 Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
682033 Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
362739 Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
363122 Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
309179 Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
691318 Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4
363193 Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
299147 Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
312754 Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
24842 Tp53; cellular tumor antigen p53
25047 Fcer1a; high affinity immunoglobulin epsilon receptor subunit alpha precursor
25316 Ms4a2; high affinity immunoglobulin epsilon receptor subunit beta
25441 Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma precursor
25150 Fyn; tyrosine-protein kinase Fyn
84477 Gab2; GRB2-associated-binding protein 2
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta
25097 Pld2; phospholipase D2
25096 Pld1; phospholipase D1 isoform 2
308589 Sphk2; sphingosine kinase 2
170897 Sphk1; sphingosine kinase 1 isoform b
24903 Kng2; T-kininogen 1 precursor
25087 Kng2l1; kininogen-1 isoform 1 precursor
288001 Kng1; T-kininogen 2 precursor
29290 Adora1; adenosine receptor A1
100911796 Adora3; adenosine receptor A3 isoform b
25245 Bdkrb2; B2 bradykinin receptor isoform 2
24613 Oprd1; delta-type opioid receptor
25686 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1
25643 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3
81664 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
29340 Prkce; protein kinase C epsilon type
116590 Mapk1; mitogen-activated protein kinase 1
50689 Mapk3; mitogen-activated protein kinase 3
81536 Sgpp1; sphingosine-1-phosphate phosphatase 1
301543 Sgpp2; sphingosine-1-phosphate phosphatase 2
24565 Abcc1; multidrug resistance-associated protein 1
286896 Sgpl1; sphingosine-1-phosphate lyase 1
29733 S1pr1; sphingosine 1-phosphate receptor 1
29415 S1pr2; sphingosine 1-phosphate receptor 2
293621 Hras; GTPase HRas
367858 Hrasl1; HRas proto-oncogene, GTPase like 1
24525 Kras; GTPase KRas
24605 Nras; GTPase NRas
24703 Raf1; RAF proto-oncogene serine/threonine-protein kinase
170851 Map2k1; dual specificity mitogen-activated protein kinase kinase 1
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2
81745 Pdpk1; 3-phosphoinositide-dependent protein kinase 1
24600 Nos3; nitric oxide synthase 3
363875 Rac1; ras-related C3 botulinum toxin substrate 1
366957 Rac2; ras-related C3 botulinum toxin substrate 2
688319 Rac3; ras-related C3 botulinum toxin substrate 3
306792 S1pr3; sphingosine 1-phosphate receptor 3
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha
24680 Prkca; protein kinase C alpha type
25023 Prkcb; protein kinase C beta type isoform 2
24681 Prkcg; protein kinase C gamma type
314649 S1pr4; sphingosine 1-phosphate receptor 4
60399 S1pr5; sphingosine 1-phosphate receptor 5
81663 Gna12; guanine nucleotide-binding protein subunit alpha-12
303634 Gna13; guanine nucleotide-binding protein subunit alpha-13
117273 Rhoa; transforming protein RhoA
297173 RSA-14-44; ras homolog gene family, member A
81762 Rock1; rho-associated protein kinase 1
25537 Rock2; rho-associated protein kinase 2
50557 Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2
309165 Rela; transcription factor p65
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K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50]
K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50]
K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50]
K26384 SPTSS; serine palmitoyltransferase small subunit
K26384 SPTSS; serine palmitoyltransferase small subunit
K04710 CERS1; sphingoid base N-stearoyltransferase [EC:2.3.1.299]
K24621 CERS2_4; very-long-chain ceramide synthase [EC:2.3.1.297]
K24621 CERS2_4; very-long-chain ceramide synthase [EC:2.3.1.297]
K24622 CERS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase [EC:2.3.1.297 2.3.1.298]
K23727 CERS5_6; sphingoid base N-palmitoyltransferase [EC:2.3.1.291]
K23727 CERS5_6; sphingoid base N-palmitoyltransferase [EC:2.3.1.291]
K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
K12350 SMPD1; sphingomyelin phosphodiesterase [EC:3.1.4.12]
K04714 SGMS; shingomyelin synthase [EC:2.7.8.27]
K04714 SGMS; shingomyelin synthase [EC:2.7.8.27]
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K18953 NSMAF; factor associated with neutral sphingomyelinase activation
K12351 SMPD2; sphingomyelin phosphodiesterase 2 [EC:3.1.4.12]
K12348 ASAH1; acid ceramidase [EC:3.5.1.23]
K12349 ASAH2; neutral ceramidase [EC:3.5.1.23]
K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23]
K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23]
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K01379 CTSD; cathepsin D [EC:3.4.23.5]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K02159 BAX; apoptosis regulator BAX
K02159 BAX; apoptosis regulator BAX
K04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K18952 PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02161 BCL2; apoptosis regulator Bcl-2
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K04451 TP53; tumor protein p53
K08089 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha
K08090 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta
K07983 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma
K05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
K08091 GAB2; GRB2-associated-binding protein 2
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04718 SPHK; sphingosine kinase [EC:2.7.1.91]
K04718 SPHK; sphingosine kinase [EC:2.7.1.91]
K03898 KNG; kininogen
K03898 KNG; kininogen
K03898 KNG; kininogen
K04265 ADORA1; adenosine receptor A1
K04268 ADORA3; adenosine receptor A3
K03916 BDKRB2; bradykinin receptor B2
K04213 OPRD1; delta-type opioid receptor
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04716 SGPP1; sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-]
K04717 SGPP2; sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]
K05665 ABCC1; ATP-binding cassette, subfamily C (CFTR/MRP), member 1 [EC:7.6.2.3]
K01634 SGPL1; sphinganine-1-phosphate aldolase [EC:4.1.2.27]
K04288 S1PR1; sphingosine 1-phosphate receptor 1
K04292 S1PR2; sphingosine 1-phosphate receptor 2
K02833 HRAS; GTPase HRas
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K13242 NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04290 S1PR3; sphingosine 1-phosphate receptor 3
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K04293 S1PR4; sphingosine 1-phosphate receptor 4
K04295 S1PR5; sphingosine 1-phosphate receptor 5
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
K04513 RHOA; Ras homolog gene family, member A
K04513 RHOA; Ras homolog gene family, member A
K04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
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04024 cAMP signaling pathway [PATH:rno04024]
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04022 cGMP-PKG signaling pathway [PATH:rno04022]
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04151 PI3K-Akt signaling pathway [PATH:rno04151]
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04152 AMPK signaling pathway [PATH:rno04152]
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04150 mTOR signaling pathway [PATH:rno04150]
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04075 Plant hormone signal transduction
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09133 Signaling molecules and interaction
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09140 Cellular Processes
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Rattus norvegicus (rat)