PCIDB

KNApSAcK Metabolite C00001425

Metabolite

KNApSAcK Entry

id C00001425
Name Octopamine
CAS RN 104-14-3
Standard InChI InChI=1S/C8H11NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H,5,9H2/t8-/m0/s1
Standard InChI (Main Layer) InChI=1S/C8H11NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H,5,9H2

Cluster

Phytochemical cluster
KCF-S cluster No. 4586

Link

ChEMBL

By standard InChI CHEMBL1160703
By standard InChI Main Layer CHEMBL53929 CHEMBL1160703

KEGG

By LinkDB C04227

CTD

By CAS RN D009655

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1160703 CHEMBL1741321 (2)
1 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1160703 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL53929 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL53929 CHEMBL2114744 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1160703 CHEMBL1614281 (1) CHEMBL1614361 (2)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1160703 CHEMBL1741325 (2)
0 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1160703 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
P46098 5-hydroxytryptamine receptor 3A NS CHEMBL53929 CHEMBL923631 (1) CHEMBL923632 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1160703 CHEMBL1741322 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1160703 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1160703 CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1160703 CHEMBL1741324 (2)
0 / 1
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL53929 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL53929 CHEMBL1737980 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL53929 CHEMBL1738442 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL53929 CHEMBL2114738 (1)
0 / 0

CTD interaction (21)

compound gene gene name gene description interaction interaction type form reference
pmid
D009655 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein] affects binding
/ decreases reaction
protein 10344530
D009655 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein] affects binding
/ decreases reaction
protein 10344530
D009655 155 ADRB3
BETA3AR
adrenoceptor beta 3 Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein] affects binding
/ decreases reaction
protein 10344530
D009655 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D009655 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D009655 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D009655 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (6)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)