PCIDB

KNApSAcK Metabolite C00002665

Metabolite

KNApSAcK Entry

id C00002665
Name Phloroglucinol
CAS RN 108-73-6
Standard InChI InChI=1S/C6H6O3/c7-4-1-5(8)3-6(9)2-4/h1-3,7-9H
Standard InChI (Main Layer) InChI=1S/C6H6O3/c7-4-1-5(8)3-6(9)2-4/h1-3,7-9H

Cluster

Phytochemical cluster No. 82
KCF-S cluster No. 1590

Link

ChEMBL

By standard InChI CHEMBL473159
By standard InChI Main Layer CHEMBL473159

KEGG

By LinkDB C02183

CTD

By CAS RN D010696

Human Protein / Gene in interaction

3 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P14679 Tyrosinase Oxidoreductase CHEMBL473159 CHEMBL2344046 (1) CHEMBL2344048 (1)
CHEMBL2344050 (1) CHEMBL2344052 (1)
4 / 2
P56817 Beta-secretase 1 A1A CHEMBL473159 CHEMBL1117923 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL473159 CHEMBL1794536 (1)
0 / 0

CTD interaction (10)

compound gene gene name gene description interaction interaction type form reference
pmid
D010696 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Phloroglucinol analog results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 23178381
D010696 581 BAX
BCL2L4
BCL2-associated X protein Phloroglucinol metabolite results in increased expression of BAX protein increases expression
protein 22796323
D010696 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Phloroglucinol metabolite results in decreased expression of BCL2 protein decreases expression
protein 22796323
D010696 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Phloroglucinol analog results in increased cleavage of CASP3 protein increases cleavage
protein 23178381
D010696 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Phloroglucinol metabolite results in increased cleavage of CASP3 protein increases cleavage
protein 22796323
D010696 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Phloroglucinol metabolite results in increased cleavage of CASP9 protein increases cleavage
protein 22796323
D010696 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 Phloroglucinol analog results in increased expression of GDF15 protein increases expression
protein 23178381
D010696 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) Phloroglucinol analog results in decreased phosphorylation of GSK3B protein decreases phosphorylation
protein 23178381
D010696 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Phloroglucinol analog results in increased cleavage of PARP1 protein increases cleavage
protein 23178381
D010696 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Phloroglucinol metabolite results in increased cleavage of PARP1 protein increases cleavage
protein 22796323

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (2)

KEGG disease name UniProt
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D011832 D010696 Radiation Injuries therapeutic
20188716
D013959 D010696 Thyroid Diseases marker/mechanism
21800831