Species

KNApSAcK Entry

Organism name Sequoia sempervirens
Genus Sequoia
Family Taxodiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sequoia sempervirens
Linked NCBI taxonomy ID 28980
Linked level species

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006487 External link 512 Sequoiaflavone
CHEMBL255493
1 / 0 / 0 No. 34 No. 18
C00001172 External link 512 Sequoyitol
/ 5-O-Methyl-myo-inositol
CHEMBL171890
CHEMBL501109
CHEMBL493737
CHEMBL460057
2 / 1 / 1 No. 795
C00002665 External link 512 Phloroglucinol
CHEMBL473159
D010696
3 / 4 / 2 8 / 2 No. 1590 No. 82
C00000597 External link 512 Sequirin B
/ (-)-Hydroxysugiresinol
No. 2651 No. 24
C00046399 External link 512 Sequoiatone E
/ (+)-Sequoiatone E
CHEMBL495444
No. 2817
C00046398 External link 512 Sequoiatone D
/ (+)-Sequoiatone D
CHEMBL495443
No. 2817
C00046397 External link 512 Sequoiatone C
/ (+)-Sequoiatone C
CHEMBL495442
No. 2817
C00046400 External link 512 Sequoiatone F
/ (+)-Sequoiatone F
No. 5094

Human Protein / Gene in interactions

5 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A C00002665 C00006487 0 / 0
P14679 Tyrosinase Oxidoreductase C00002665 4 / 2
Q9Y253 DNA polymerase eta Enzyme C00001172 1 / 1
O75496 Geminin Unclassified protein C00001172 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002665 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002665
581 BAX, BCL2L4 BCL2-associated X protein C00002665
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002665
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002665
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002665
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00002665
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00002665
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002665

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (3)

KEGG name UniProt
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D011832 Radiation Injuries C00002665
D013959 Thyroid Diseases C00002665