Species

KNApSAcK Entry

Organism name Alpinia blepharocalyx
Genus Alpinia
Family Zingiberaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Alpinia blepharocalyx
Linked NCBI taxonomy ID 105668
Linked level species

Family

Family in NCBI taxonomy Zingiberaceae
ID 4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (36)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006919 External link 512 4,4'-Dihydroxychalcone
CHEMBL145927
C007423
No. 92 No. 13
C00006954 External link 512 Helichrysetin
/ 4,2',4'-Trihydroxy-6'-methoxychalcone
CHEMBL507998
C061023
No. 92 No. 13
C00014289 External link 512 Calyxin K
CHEMBL455334
CHEMBL450782
No. 200
C00014576 External link 512 Epicalyxin H
CHEMBL1926699
No. 200
C00008123 External link 512 Calyxin A
No. 200
C00008124 External link 512 Calyxin B
No. 200
C00014285 External link 512 Calyxin C
/ 2,3-Dihydro-7-hydroxy-8-[(1S,2E,5S)-5-hydroxy-1,7-bis(4-hydroxyphenyl)-2-heptenyl]-2-(4-hydroxyphenyl)-5-methoxy-4H-1-benzopyran-4-one
No. 200
C00014286 External link 512 Calyxin D
/ 2,3-Dihydro-7-hydroxy-8-[(1R,2E,5S)-5-hydroxy-1,7-bis(4-hydroxyphenyl)-2-heptenyl]-2-(4-hydroxyphenyl)-5-methoxy-4H-1-benzopyran-4-one
No. 200
C00014287 External link 512 Calyxin G
CHEMBL455334
CHEMBL450782
No. 200
C00014575 External link 512 Calyxin H
CHEMBL1926699
No. 200
C00014571 External link 512 Deoxycalyxin A
CHEMBL504530
No. 200
C00014290 External link 512 Calyxin M
CHEMBL457496
No. 200
C00014291 External link 512 Epicalyxin C
No. 200
C00014292 External link 512 Epicalyxin D
No. 200
C00014293 External link 512 Epicalyxin G
CHEMBL455334
CHEMBL450782
No. 200
C00014573 External link 512 Calyxin F
No. 200
C00014295 External link 512 Epicalyxin K
CHEMBL455334
CHEMBL450782
No. 200
C00014296 External link 512 Epicalyxin M
CHEMBL457496
No. 200
C00014574 External link 512 Calyxin L
/ Epicalyxin F
CHEMBL451268
CHEMBL447717
No. 200
C00014572 External link 512 Epicalyxin B
/ 3-epi-Calyxin B
No. 200
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00045571 External link 512 p-Hydroxy-5,6-dehydrokawain
/ 4'-Hydroxy-5,6-dehydrokawain
CHEMBL464111
No. 1312 No. 63
C00014578 External link 512 Epicalyxin I
CHEMBL455049
CHEMBL503028
No. 1371
C00014294 External link 512 Epicalyxin J
CHEMBL510115
No. 1371
C00014577 External link 512 Calyxin I
CHEMBL455049
CHEMBL503028
No. 1371
C00014288 External link 512 Calyxin J
CHEMBL510115
No. 1371
C00014581 External link 512 Blepharocalyxin E
No. 1371
C00014580 External link 512 Blepharocalyxin B
/ (-)-Blepharocalyxin B
No. 1371
C00014579 External link 512 Blepharocalyxin A
/ (-)-Blepharocalyxin A
No. 1371
C00002665 External link 512 Phloroglucinol
CHEMBL473159
D010696
3 / 4 / 2 8 / 2 No. 1590 No. 82
C00002657 External link 512 p-Formylphenol
/ 4-Hydroxybenzaldehyde
/ p-Hydroxybenzaldehyde
CHEMBL14193
C011483
3 / 2 / 2 No. 2076
C00032012 External link 512 Methyl p-coumarate
/ Methyl p-hydroxycinnamate
/ Methyl 4-hydroxy cinnamate
/ 4-Hydroxycinnamic acid methyl ester
CHEMBL146816
C057918
6 / 2 / 4 No. 2416
C00046202 External link 512 Neocalyxin A
CHEMBL518161
No. 4904
C00046203 External link 512 Neocalyxin B
/ (-)-Neocalyxin B
CHEMBL518161
No. 4904
C00045687 External link 512 Blepharocalyxin C
/ (+)-Blepharocalyxin C
CHEMBL448211
No. 5225
C00045688 External link 512 Blepharocalyxin D
/ (+)-Blepharocalyxin D
CHEMBL446847
No. 5225

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019308 0 / 0
P06746 DNA polymerase beta Enzyme C00019308 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00032012 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00019308 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002657 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00032012 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00032012 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00032012 1 / 2
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00002657 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00032012 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019308 0 / 0
P00734 Prothrombin S1A C00019308 4 / 2
P14679 Tyrosinase Oxidoreductase C00002665 4 / 2
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002657 1 / 1
P56817 Beta-secretase 1 A1A C00002665 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00032012 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00002665 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002665
581 BAX, BCL2L4 BCL2-associated X protein C00002665
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002665
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002665
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002665
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00002665
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00002665
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002665

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#613163 Gaba-transaminase deficiency P80404
#143860 Hyperchlorhidrosis, isolated O43570
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (10)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308
D011832 Radiation Injuries C00002665
D013959 Thyroid Diseases C00002665