Chaenomeles sinensis KOEHNE
Species
KNApSAcK Entry
| Organism name | Chaenomeles sinensis KOEHNE |
|---|---|
| Genus | Chaenomeles |
| Family | Rosaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Chaenomeles |
|---|---|
| Linked NCBI taxonomy ID | 36603 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Rosaceae |
|---|---|
| ID | 3745 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (14)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005367
|
Avicularin
/ Avicularine / Avicularoside / Quercetin 3-alpha-L-arabinofuranoside / Quercetin 3-O-alpha-L-arabinofuranoside |
CHEMBL471282
CHEMBL1590676 |
C041388
|
10 / 2 / 3 | No. 2 | No. 15 |
|
|
|
C00019491
|
Euscophic acid
/ Jacarandic acid / 2alpha,3alpha,19alpha-Trihydroxyurs-12-en-28-oic acid |
CHEMBL223484
CHEMBL239077 CHEMBL1270647 |
C007695
|
2 / 2 / 2 | No. 13 | No. 51 |
|
|
|
C00031690
|
Corosolic acid
|
CHEMBL391533
CHEMBL237535 CHEMBL391534 CHEMBL574993 |
C113861
|
17 / 7 / 6 | No. 13 | No. 51 |
|
|
|
C00019490
|
Tormentic acid
/ 2alpha,3beta,19alpha-Trihydroxyurs-12-en-28-oic acid |
CHEMBL223484
CHEMBL239077 CHEMBL1270647 |
2 / 2 / 2 | No. 13 | No. 51 |
|
||
|
C00030742
|
Maslinic acid
/ Crategolic acid / 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid |
CHEMBL201515
CHEMBL383749 CHEMBL482673 CHEMBL577380 |
C412811
|
8 / 5 / 4 | No. 13 | No. 51 |
|
|
|
C00019065
|
Erythrodiol
/ 3beta-Erythrodiol |
CHEMBL298604
CHEMBL60687 CHEMBL400074 |
C077953
|
4 / 0 / 1 | No. 13 | No. 51 |
|
|
|
C00003741
|
Betulinic acid
|
CHEMBL269277
CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635 |
C002070
|
34 / 17 / 14 | 10 / 2 | No. 23 | No. 51 |
|
|
C00003740
|
Betulin
|
CHEMBL23236
CHEMBL140040 CHEMBL1610940 CHEMBL2000891 CHEMBL2069124 |
C002503
|
18 / 16 / 17 | 0 / 2 | No. 23 | No. 51 |
|
|
C00029677
|
Alphitolic acid
|
CHEMBL511805
|
1 / 0 / 0 | No. 23 | No. 51 |
|
||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00019797
|
3-(E)-p-Coumaroylbetulin
/ (E)-Betulin-3-p-coumarate / 3-O-(E)-p-Coumaroylbetulin |
No. 78 |
|
|||||
|
C00035934
|
3-(E)-Caffeoylbetulin
/ 3-O-(E)-Caffeoylbetulin |
CHEMBL502663
|
No. 78 |
|
||||
|
C00019798
|
3-(Z)-p-Coumaroylbetulin
/ (Z)-Betulin-3-p-coumarate / 3-O-(Z)-p-Coumaroylbetulin |
No. 78 |
|
|||||
|
C00031615
|
Aviculin
/ (+)-Aviculin |
No. 174 | No. 22 |
|
Human Protein / Gene in interactions
65 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00003740 C00019065 C00030742 C00031690 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00003741 C00005367 C00019065 C00030742 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 C00019490 C00019491 C00031690 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 C00003740 C00003741 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00003740 C00003741 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003741 C00019065 C00030742 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003741 C00005367 C00031690 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00003741 C00031690 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00019490 C00019491 C00031690 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00003740 C00003741 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00003740 C00003741 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 C00003740 C00003741 | 0 / 1 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00019065 C00030742 C00031690 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00003740 C00003741 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003740 C00003741 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003740 C00003741 | 11 / 10 |
| P05771 | Protein kinase C beta type | Alpha | C00003740 C00003741 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00030742 C00031690 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003740 C00003741 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00005367 C00031690 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003740 C00003741 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003740 C00003741 | 0 / 0 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00030742 C00031690 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003740 C00003741 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 C00003741 | 2 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00003741 C00029677 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003740 C00003741 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00003741 C00005367 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003741 C00005367 | 0 / 0 |
| P11217 | Glycogen phosphorylase, muscle form | Enzyme | C00030742 C00031690 | 1 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00003741 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003741 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003741 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00031690 | 2 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005367 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00005367 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00031690 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003741 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003740 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P42858 | Huntingtin | Unclassified protein | C00031690 | 1 / 1 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003741 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00031690 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005367 | 0 / 0 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00003741 | 0 / 0 |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | C00003741 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003741 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003740 | 3 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005367 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00031690 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00030742 | 4 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003740 | 0 / 3 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00031690 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00031690 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003741 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00003741 | 0 / 0 |
| Q9UBT2 | SUMO-activating enzyme subunit 2 | Enzyme | C00003741 | 0 / 0 |
| Q9UBE0 | SUMO-activating enzyme subunit 1 | Unclassified protein | C00003741 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005367 | 0 / 0 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003741
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003741
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00003741
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003741
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003741
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003741
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003741
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003741
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003741
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003741
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (46)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232600 | Glycogen storage disease v |
P11217
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (35)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P11217
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|