Leonurus persicus
Species
KNApSAcK Entry
| Organism name | Leonurus persicus |
|---|---|
| Genus | Leonurus |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Leonurus |
|---|---|
| Linked NCBI taxonomy ID | 4137 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (24)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005138
|
Astragalin
/ Kaempferol 3-glucoside / Kaempferol 3-O-beta-D-glucoside / Kaempferol 3-O-beta-D-glucopyranoside |
CHEMBL233930
CHEMBL453290 CHEMBL1572115 |
C001579
|
10 / 6 / 7 | 0 / 1 | No. 2 | No. 15 |
|
|
C00030657
|
Leucosceptoside A
|
CHEMBL450121
|
1 / 0 / 0 | No. 33 |
|
|||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00010601
|
Ajugoside
|
CHEMBL605532
|
C477173
|
No. 56 | No. 36 |
|
||
|
C00010570
|
8-Acetylharpagide
/ Harpagide 7-acetate / 8-O-Acetylharpagide |
CHEMBL523290
CHEMBL595293 |
C077626
|
1 / 2 / 0 | No. 56 | No. 36 |
|
|
|
C00010480
|
Galiridoside
|
No. 64 | No. 36 |
|
||||
|
C00049601
|
10-Deoxygeniposidic acid
|
No. 100 | No. 36 |
|
||||
|
C00042055
|
15-epi-Leopersin O
|
No. 201 |
|
|||||
|
C00050378
|
Leopersin K
/ (-)-Leopersin K |
No. 201 |
|
|||||
|
C00042691
|
Leopersin Q
|
No. 201 |
|
|||||
|
C00050317
|
15-epi-Leopersin J
|
No. 201 |
|
|||||
|
C00050377
|
Leopersin J
|
No. 201 |
|
|||||
|
C00050375
|
Leopersin H
/ (+)-Leopersin H |
No. 201 |
|
|||||
|
C00042690
|
Leopersin O
|
No. 201 |
|
|||||
|
C00042056
|
15-epi-Leopersin Q
|
No. 201 |
|
|||||
|
C00042059
|
19-Hydroxygaleopsin
|
No. 417 |
|
|||||
|
C00022394
|
Ballotenol
|
No. 1134 |
|
|||||
|
C00042689
|
Leopersin N
|
No. 2118 |
|
|||||
|
C00050376
|
Leopersin I
/ (+)-Leopersin I |
No. 2118 |
|
|||||
|
C00050374
|
Leopersin G
/ (+)-Leopersin G |
No. 2427 |
|
|||||
|
C00042688
|
Leopersin M
|
No. 2897 |
|
|||||
|
C00022433
|
13-Hydroxyballonigrinolide
|
No. 4201 |
|
|||||
|
C00050379
|
Leopersin L
/ (-)-Leopersin L |
No. 4201 |
|
Human Protein / Gene in interactions
32 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00023774 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00005138 | 4 / 2 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005138 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00030657 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005138 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005138 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00010570 | 2 / 0 |
| P15121 | Aldose reductase | Enzyme | C00005138 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00005138 | 1 / 1 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00005138 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005138 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005138 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00005138 | 0 / 3 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (23)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (15)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|