Species

KNApSAcK Entry

Organism name Leonurus persicus
Genus Leonurus
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Leonurus
Linked NCBI taxonomy ID 4137
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (24)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00030657 External link 512 Leucosceptoside A
CHEMBL450121
1 / 0 / 0 No. 33
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00010601 External link 512 Ajugoside
CHEMBL605532
C477173
No. 56 No. 36
C00010570 External link 512 8-Acetylharpagide
/ Harpagide 7-acetate
/ 8-O-Acetylharpagide
CHEMBL523290
CHEMBL595293
C077626
1 / 2 / 0 No. 56 No. 36
C00010480 External link 512 Galiridoside
No. 64 No. 36
C00049601 External link 512 10-Deoxygeniposidic acid
No. 100 No. 36
C00042055 External link 512 15-epi-Leopersin O
No. 201
C00050378 External link 512 Leopersin K
/ (-)-Leopersin K
No. 201
C00042691 External link 512 Leopersin Q
No. 201
C00050317 External link 512 15-epi-Leopersin J
No. 201
C00050377 External link 512 Leopersin J
No. 201
C00050375 External link 512 Leopersin H
/ (+)-Leopersin H
No. 201
C00042690 External link 512 Leopersin O
No. 201
C00042056 External link 512 15-epi-Leopersin Q
No. 201
C00042059 External link 512 19-Hydroxygaleopsin
No. 417
C00022394 External link 512 Ballotenol
No. 1134
C00042689 External link 512 Leopersin N
No. 2118
C00050376 External link 512 Leopersin I
/ (+)-Leopersin I
No. 2118
C00050374 External link 512 Leopersin G
/ (+)-Leopersin G
No. 2427
C00042688 External link 512 Leopersin M
No. 2897
C00022433 External link 512 13-Hydroxyballonigrinolide
No. 4201
C00050379 External link 512 Leopersin L
/ (-)-Leopersin L
No. 4201

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003672 C00023774 0 / 0
P14679 Tyrosinase Oxidoreductase C00003672 C00005138 4 / 2
Q9Y253 DNA polymerase eta Enzyme C00005138 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
P17252 Protein kinase C alpha type Alpha C00030657 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P07237 Protein disulfide-isomerase Enzyme C00005138 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00010570 2 / 0
P15121 Aldose reductase Enzyme C00005138 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005138 1 / 1
P00734 Prothrombin S1A C00003672 4 / 2
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005138 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005138 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (15)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138