Species

KNApSAcK Entry

Organism name Hyptis brevipes
Genus Hyptis
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hyptis brevipes
Linked NCBI taxonomy ID 204123
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004643 External link 512 Ombuin
/ 4',7-Dimethylquercetin
/ 3,5,3'-Trihydroxy-7,4'-dimethoxyflavone
/ 3,5-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL75589
1 / 1 / 1 No. 3 No. 15
C00004647 External link 512 Ayanin
/ 3,7,4'-Tri-O-methylquercetin
/ 5,3'-Dihydroxy-3,7,4'-trimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL74898
18 / 10 / 2 No. 3 No. 15
C00030742 External link 512 Maslinic acid
/ Crategolic acid
/ 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid
CHEMBL201515
CHEMBL383749
CHEMBL482673
CHEMBL577380
C412811
8 / 5 / 4 No. 13 No. 51
C00029633 External link 512 Ursolic acid
/ Acetylursolic acid
CHEMBL55086
CHEMBL410525
4 / 2 / 2 No. 177
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00047403 External link 512 Brevipolide A
/ (+)-Brevipolide A
CHEMBL1085179
CHEMBL1088630
1 / 0 / 0 No. 1573
C00047404 External link 512 Brevipolide B
/ (+)-Brevipolide B
CHEMBL1085179
CHEMBL1088630
1 / 0 / 0 No. 1573
C00047405 External link 512 Brevipolide C
/ (+)-Brevipolide C
CHEMBL1086650
CHEMBL1086651
1 / 0 / 0 No. 1573
C00047406 External link 512 Brevipolide D
/ (+)-Brevipolide D
CHEMBL1086650
CHEMBL1086651
1 / 0 / 0 No. 1573
C00047407 External link 512 Brevipolide E
/ (+)-Brevipolide E
CHEMBL1088210
1 / 0 / 0 No. 1573
C00047408 External link 512 Brevipolide F
/ (+)-Brevipolide F
CHEMBL363999
CHEMBL1085427
CHEMBL2337108
2 / 3 / 0 No. 1573

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00047403 C00047404 C00047405 C00047406 C00047407 C00047408 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019308 C00030742 0 / 0
P06746 DNA polymerase beta Enzyme C00019308 C00029633 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00030742 0 / 1
P11217 Glycogen phosphorylase, muscle form Enzyme C00030742 1 / 1
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00030742 4 / 2
P08047 Transcription factor Sp1 Unclassified protein C00019308 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004643 1 / 1
P08183 Multidrug resistance protein 1 drug C00004647 1 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00030742 0 / 0
P15121 Aldose reductase Enzyme C00030742 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019308 0 / 0
P00734 Prothrombin S1A C00019308 4 / 2
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00029633 2 / 2
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00047408 3 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004647 2 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00004647 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00029633 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00030742 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00030742 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00029633 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00004647 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004647 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004647 1 / 0
P04350 Tubulin beta-4A chain Structural C00004647 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004647 0 / 0
P07437 Tubulin beta chain Structural C00004647 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004647 1 / 1
P68371 Tubulin beta-4B chain Structural C00004647 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004647 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00004647 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004647 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004647 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004647 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004647 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004647 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614490 Blood group, junior system; jr Q9UNQ0
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#232600 Glycogen storage disease v P11217
#609423 Human immunodeficiency virus type 1, susceptibility to P51681
#612244 Inflammatory bowel disease 13; ibd13 P08183
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#156250 Metachondromatosis; metcds Q06124
#163950 Noonan syndrome 1; ns1 Q06124
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989

KEGG DISEASE (11)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00069 Glycogen storage diseases (GSD) P11217 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00408 Type I diabetes mellitus P17706 (related)
H00192 Xanthinuria P47989 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308