Species

KNApSAcK Entry

Organism name Stemona collinsae
Genus Stemona
Family Stemonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stemona collinsae
Linked NCBI taxonomy ID 492015
Linked level species

Family

Family in NCBI taxonomy Stemonaceae
ID 49662

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (33)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009597 External link 512 Stemonacetal
No. 8 No. 15
C00009596 External link 512 Stemonal
No. 8 No. 15
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00034285 External link 512 Stemanthrene B
CHEMBL480659
No. 75 No. 28
C00034286 External link 512 Stemanthrene C
CHEMBL480660
No. 75 No. 28
C00034284 External link 512 Stemanthrene A
CHEMBL480658
No. 75 No. 28
C00034287 External link 512 Stemanthrene D
CHEMBL444939
No. 75 No. 28
C00046420 External link 512 Stemofuran C
CHEMBL462853
No. 76 No. 15
C00046418 External link 512 Stemofuran A
CHEMBL464900
No. 76 No. 15
C00046421 External link 512 Stemofuran D
CHEMBL464901
No. 76 No. 15
C00035754 External link 512 Stilbostemin E
CHEMBL464236
No. 96 No. 26
C00046430 External link 512 Stilbostemin F
CHEMBL464292
No. 96 No. 26
C00035753 External link 512 Stilbostemin D
CHEMBL462852
No. 96 No. 26
C00046419 External link 512 Stemofuran B
/ Gnetifolin M (stilbene)
CHEMBL511197
No. 210 No. 15
C00046428 External link 512 Stilbostemin A
CHEMBL464899
No. 242 No. 26
C00035502 External link 512 4'-Methylpinosylvin
CHEMBL463252
No. 295 No. 13
C00002897 External link 512 Pinosylvin
/ Pinosylvine
/ 3,5-Dihydroxystilbene
CHEMBL101506
CHEMBL2203685
1 / 0 / 1 No. 295 No. 13
C00000614 External link 512 Coniferyl alcohol
CHEMBL501870
CHEMBL2088631
C010559
No. 310 No. 6
C00034434 External link 512 Asparagamine A
/ Didehydrostemofoline
No. 372
C00036421 External link 512 16,17-Dihydro-4(E)-16(E)-stemofoline
CHEMBL1082736
CHEMBL1807141
1 / 1 / 0 No. 372
C00034422 External link 512 2'-Hydroxystemofoline
CHEMBL491987
CHEMBL1082732
CHEMBL1082733
CHEMBL1807142
CHEMBL1807144
1 / 1 / 0 No. 372
C00029045 External link 512 Stemofoline
/ (+)-Stemofoline
CHEMBL1084524
CHEMBL2304257
C430220
1 / 1 / 0 No. 372
C00009595 External link 512 Stemonone
No. 473
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00035791 External link 512 all-rac-3,4-Dehydro-alpha-tocopherol
No. 1290
C00046426 External link 512 Stemofuran J
CHEMBL513285
No. 1387
C00046422 External link 512 Stemofuran E
CHEMBL449756
No. 1387
C00046425 External link 512 Stemofuran I
No. 1387
C00046423 External link 512 Stemofuran G
CHEMBL513458
No. 1387
C00046424 External link 512 Stemofuran H
No. 1387
C00046427 External link 512 Stemofuran K
CHEMBL1642208
No. 1387
C00046429 External link 512 Stilbostemin C
CHEMBL464291
No. 3097
C00035752 External link 512 Stilbostemin B
CHEMBL464662
No. 3097

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22303 Acetylcholinesterase Hydrolase C00029045 C00034422 C00036421 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P06746 DNA polymerase beta Enzyme C00023774 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O75496 Geminin Unclassified protein C00000601 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002897 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#112100 Yt blood group antigen P22303

KEGG DISEASE (16)

KEGG name UniProt
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601