Species

KNApSAcK Entry

Organism name Cupressus lusitanica
Genus Cupressus
Family Cupressaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hesperocyparis lusitanica
Linked NCBI taxonomy ID 103968
Linked level species

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006490 External link 512 Podocarpusflavone A
CHEMBL220745
C094150
2 / 1 / 2 No. 34 No. 18
C00006460 External link 512 4'-O-Methylcupressuflavone
No. 34 No. 18
C00000609 External link 512 (-)-Arctigenin
CHEMBL369142
CHEMBL435734
CHEMBL1966556
C071942
13 / 7 / 6 No. 223 No. 21
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00003062 External link 512 beta-Thujaplicin
CHEMBL48310
C009479
27 / 27 / 50 No. 1304 No. 35
C00003063 External link 512 gamma-Thujaplicin
CHEMBL1275999
No. 1304 No. 35

Human Protein / Gene in interactions

41 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000609 C00003062 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000609 C00003062 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00003062 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00003062 4 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003062 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000609 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00003062 0 / 0
P22894 Neutrophil collagenase M10A C00003062 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00003062 2 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000609 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00003062 2 / 3
P43235 Cathepsin K C1A C00006490 1 / 2
O15296 Arachidonate 15-lipoxygenase B Enzyme C00003062 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003062 0 / 0
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P42858 Huntingtin Unclassified protein C00003062 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000609 2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000609 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000609 1 / 0
P03956 Interstitial collagenase M10A C00003062 0 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00003062 7 / 37
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00003062 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000609 0 / 0
P56817 Beta-secretase 1 A1A C00006490 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000609 0 / 0
P08253 72 kDa type IV collagenase M10A C00003062 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00003062 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00000609 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003062 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003062 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000609 1 / 1
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000609 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000609 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003062 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003062 0 / 0
P08254 Stromelysin-1 M10A C00003062 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00003062 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003062 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003062 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003062 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003062 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (34)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#114500 Colorectal cancer; crc P18054
P84022
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#265800 Pycnodysostosis P43235
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (56)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00028 Choriocarcinoma P03956 (related)
P04637 (related)
P08253 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00472 Torg-Winchester syndrome P08253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)